Comparison of Analgesic Effect of Intra-Articular Buprenorphine and Morphine Following Arthroscopic Surgery of Knee

Abstract

BACKGROUND AND AIMSPain after orthopaedic surgery depends on the site and extent of surgery and the preoperative use of analgesics by the patient. Arthroscopic procedures are routinely performed on outpatient basis and have spared patients large incisions and decreased morbidity compared with open incisions, but has not eliminated pain. At present several techniques are available to treat pain following arthroscopic surgeries; these include the use of opioids, local anaesthetics, NSAIDs, corticosteroids, clonidine and cryotherapy. Here, we compared the analgesic effect of intra-articular administration of morphine, buprenorphine and placebo following arthroscopic surgery of knee.

Efficacy of intra-articular dexmedetomidine versus buprenorphine for postoperative analgesia following knee arthroscopy: A comparative study

“…This is similar to a study where patients receiving IA buprenorphine need less number of rescue analgesia. [13]…”

Pharmacokinetics of intra‐articular buprenorphine in horses with lipopolysaccharide‐induced synovitis

“…In horses, buprenorphine has been studied for the treatment of perioperative pain, showing better analgesic effects than butorphanol for field castration, at a dosage of 5 μg/kg (Rigotti et al, 2014). In human medicine, IA buprenorphine has been used for the treatment of joint pain after knee arthroscopy (Das & Samal, 2019; Sugandarajappa et al, 2016; Varrassi et al, 1999), shoulder surgery (Fellahi et al, 1995), and temporomandibular joint arthrocentesis (Präger et al, 2007).…”

Comparing the Effect of Dexamethasone, Normal Saline, and Metoclopramide on Prevention of Postoperative Nausea, Vomiting and Pain in Patient Undergoing Laparoscopic Cholecystectomy or Open Appendectomy: A Randomized Clinical Trial

“…Weighing the risk-benefit ratio, a new reporting proposes a solitary dose of dexamethasone 4-8 mg is harmless when used prophylactically for PONV [7]. Pain management postoperatively is a chief alarm for clinicians and for patients enduring surgery [8]. Post-operative pain not only disturbs the patients operative outcome, health, and fulfillment from medical care but also directly affects the progress of tachycardia, hyperventilation, alveolar ventilation reduction, pain, healing wound poorly, and insomnia, which sequentially may affect the outcomes of operation [9].…”