Comparison of analgesic effect of intrathecal morphine alone or in combination with bupivacaine and fentanyl in patients undergoing total gastrectomy: A prospective randomised, double blind clinical trial

Slavkovic, Zoran; Stamenković, Dušica; Gerić, Veselin; Veljović, Milić; Ivanoviić, Nebojsa; Tomic, Aleksandar; Randjelović, Tomislav; Raskovic, J.; Καρανικόλας, Μενέλαος

doi:10.2298/vsp111011011s

Cited by 3 publications

(3 citation statements)

References 15 publications

(10 reference statements)

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“…It is a safe and manageable solution in pain management and can be considered for chronic refractory pain from all sources. Our data shows a longer follow up and case study than the others in the literature [56, 57, 58, 59, 60, 61, 62] and this reinforces our obtained results.…”

Section: Discussionsupporting

confidence: 92%

Cancer- and non-cancer related chronic pain: from the physiopathological basics to management

et al. 2019

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AbstractThe prevalence of chronic pain is between 33% to 64% and is due to cancer pain, but it has also been observed in non-cancer patients. Chronic pain is associated with lower quality of life and higher psychological distress and depressive/anxiety disorders in patients without a history of disorder.In this study we evaluated in clinical practice the effectiveness of the intrathecal pump in 140 patients who underwent pain therapy at our Center. These patients were consecutively enrolled from January 2010 to July 2018.Follow-up was carried out over these eight years regarding the infusion modalities. Pain relief was obtained in 71 (50,7%) patients out of the 140 that experienced satisfactory pain control globally.Intrathecal therapy is one of the best options for chronic severe refractory pain. The greatest advantage of this therapy is due to the possibility of treating the pain with minimal dosages of the drug, avoiding the appearance of troublesome side effects.

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Section: Discussionsupporting

confidence: 92%

Cancer- and non-cancer related chronic pain: from the physiopathological basics to management

et al. 2019

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“…Zoran Slavkovic studied the effectiveness of pain relief at rest, on exercise and coughing after gastrectomy. The result indicated all patients were satisfied with pain relief during 72 hours [14]. In our study, the VAS at rest and on slight movement in 24 hours after surgery were low.…”

Section: Discussionsupporting

confidence: 48%

“…Sugammadex was used to reverse muscle relaxants for all patients. Extubation criteria were recovery from anesthesia, spontaneous breathing, hemodynamic stability and normothermia, but the decision for extubation was at the discretion of the anesthesia and surgery providers [14].…”

Section: Study Contentsmentioning

confidence: 99%

Efficacy of Intrathecal Morphine After Laparoscopic Surgery for Colorectal Cancer at Can Tho University of Medicine and Pharmacy Hospital

Nguyen

et al. 2023

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Background: There have been many studies in using intrathecal morphine order to reduce pain after obstetrics and gynecological surgeries, abdominal surgeries and orthopedic surgeries. These studies have shown that intrathecal morphine is very effective for pain relief after surgery. However, intrathecal morphine also has side effects especially in obstetric and gynecological surgeries such as pruritus, postoperative nausea and vomiting, and delayed respiratory depression. Although postoperative analgesia with intrathecal morphine has been widely used in obstetrics and gynecological surgeries, orthopedic surgeries, there have been very few studies on postoperative pain relief with intrathecal morphine for colorectal surgery. Laparoscopic colorectal surgery requires multimodal analgesia, so using intrathecal morphine to reduce postoperative pain in this surgery is essential in clinical practice. Therefore, studying the effectiveness of intrathecal morphine in this surgery is necessary, so we conducted this study. Objectives: To assess the effectiveness of analgesic and side effects of intrathecal morphine after laparoscopic colorectal surgery. Materials and Methods: This was a descriptive, cross-sectional study, including 63 patients undergoing laparoscopic colorectal cancer surgery with intrathecal morphine before general anesthesia. The degree of analgesia was assessed based on VAS. The postoperative side effects observed were postoperative nausea and vomiting, respiratory depression, and pruritus. Results: The analgesic effect at rest and on slight movement was 95.2%, and 88.9% respectively with VAS ≤ 3. The side effects were postoperative nausea and vomiting (6.3%), and pruritus (1.6%), both postoperative nausea and vomiting and pruritus (3.2%). In conclusion, 300µg intrathecal morphine showed a safe and positive analgesic effect for laparoscopic colorectal cancer surgery.

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Endogenous opiates and behavior: 2014

Bodnar

2016

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Comparison of analgesic effect of intrathecal morphine alone or in combination with bupivacaine and fentanyl in patients undergoing total gastrectomy: A prospective randomised, double blind clinical trial

Abstract: Compared to IT morphine alone, triple IT combination administered as part of CSE provided better intraoperative analgesia, but conferred no benefit with regards to postoperative analgesia.

Cited by 3 publications

References 15 publications

Cancer- and non-cancer related chronic pain: from the physiopathological basics to management

Cancer- and non-cancer related chronic pain: from the physiopathological basics to management

Efficacy of Intrathecal Morphine After Laparoscopic Surgery for Colorectal Cancer at Can Tho University of Medicine and Pharmacy Hospital

Endogenous opiates and behavior: 2014

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