Cancer- and non-cancer related chronic pain: from the physiopathological basics to management

Sica, Antonello; Casale, Beniamino; Dato, Maria Teresa Di; Calogero, Armando; Spada, Alessandro; Sagnelli, Caterina; Santagata, Mario; Buonavolontà, Pietro; Fiorelli, Alfonso; Salzano, Anna Maria; Dodaro, Concetta Anna; Martinelli, Erika; Saracco, Elisabetta; Troiani, Teresa; Tammaro, Dario; Papa, Alfonso

doi:10.1515/med-2019-0088

Cited by 30 publications

(20 citation statements)

References 53 publications

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“…The failure of antibiotic therapy can be the result of various components, for example, an inadequate function of the immune system. This occurs mostly in patients suffering from a congenital or acquired immunodeficiency (e.g., AIDS) or in subjects undergoing organ transplantation and in therapy with immunosuppressive drugs [17].…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Treatment and Pulmonary Rehabilitation for Management of Lung Abscess in Elderly Lymphoma Patients

Cascone

Sica

Sagnelli

et al. 2020

IJERPH

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Background: The management of lung abscess may be a challenge in elderly patients undergoing chemotherapy and/or radiotherapy for previous malignancy. Herein, we reported a case series of elderly patients with previous lymphoma undergoing endoscopic treatment followed by pulmonary rehabilitation for lung abscess. Methods: Our study population included a consecutive series of elderly patients with previous lymphoma and lung abscess. Suppurative infection was refractory with specific antibiotic therapy. In all cases, drainage was endoscopically inserted in lung abscess via video-bronchoscopy. This strategy allowed performing daily therapy with the installation of gentamicin directly into the abscess cavity. All patients underwent a respiratory rehabilitation program to speed up convalescence and allow early discharge. Results: After positioning the catheter through a bronchoscopic route and subsequent washing with gentamicin, all the patients in our study showed an improvement in clinical conditions with resolution of fever within a few days of starting the procedure with normalization of blood tests (mean hospital length 7 ± 0.73 days). A follow-up chest computed tomography scan showed a resolution of lung abscess within a mean of 27 ± 1.53 days. Conclusions: Endoscopic treatment with a rehabilitation program may be a valuable strategy for the management of lung abscess that is refractory to standard antibiotic therapy. Further and larger studiesshould be done to confirm our results.

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Section: Discussionmentioning

confidence: 99%

Endoscopic Treatment and Pulmonary Rehabilitation for Management of Lung Abscess in Elderly Lymphoma Patients

Cascone

Sica

Sagnelli

et al. 2020

IJERPH

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“…Lamivudine prophylaxis at the dose of 100 mg/day was administered 4 weeks before the start of chemotherapy, in order to prevent HBV reactivation. In March 2017, chlorambucil therapy was administered together with oral opioids for pain control [31]. In the following 2 months, the patient lost other 5 kg, because of the difficulty in feeding, and suffered of severe fatigue, which forced him to bed all day long; at this time, his body weight was 40 kg and his BMI 16.4 kg/m 2 .…”

Section: Case Reportmentioning

confidence: 99%

An Anecdotal Case Report of Chronic Lymphatic Leukemia with del(11q) Treated with Ibrutinib: Artificial Nourishment and Physical Activity Program

Sica

Sagnelli

Papa

et al. 2020

IJERPH

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Chronic lymphatic leukemia (CLL) is the most frequent type of leukemia in western countries and when association with del(11q) is correlated with a worse prognosis. We reported the clinical case of an 80-year-old patient with CLL related to del(11q) and a BMI of 16.4 kg/m2, who presented a voluminous mass in abdominal cavity (23 × 14 × 4 cm) which occupied the whole of the mesentery and the retroperitoneal space, treated with ibrutinib, adequate nutrition, and a program of physical activity. He showed a great improvement under ibrutinib therapy and took to artificial nourishment and adequate muscle rehabilitation until he recovered his autonomy. In August 2018, a 5-days-a-week training program was started: Physical activity for at least 20 min consisting of a fast walk in the open air three times a week and a moderate physical activity in the remaining two days of at least 20 consecutive minutes (cycling at a regular pace, carrying light weights). The exercise program included also aerobic, upper and lower limb resistance training, chore stability and stretches. The physical condition further improved and remained excellent throughout the follow-up period. In December 2018, his clinical condition was quite normal; a CT showed a great decrease of all lymphoadenomegaly, and FISH test did not show del(11q). He continued to cultivate his land, while still being treated with ibrutinib. The combination of the right therapy, adequate nutrition, and muscle rehabilitation is the best solution to improve the clinical condition of old cachectic CLL del(11q) patient.

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“…Physical activity and session times were measured using the Long Form, the last 7 days, selfadministered by the IPAQ. All this improves the patient's quality of life [52].…”

Section: Introductionmentioning

confidence: 99%

Post-Transplant Lymphoproliferative Diseases in the Elderly after Cardiac Transplantation: The Diagnostic Role of [18f] FDG-PET With Co-Registered CT and the Effect of Sports Activity Rehabilitation Program

Sica¹,

Rimini²,

Casale³

et al. 2019

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The incidence of cancer in organ transplant patients is higher than in the non-transplanted population. The incidence increases with increasing age. The use of Fludeoxyglucose positron emission tomography/CT (PET/CT) is sensitive and specific to detect PTLD LD compared with conventional CT imaging. We analyzed the medical data of 127 patients aged over 60 years, who underwent heart transplantation in the above period, who have been practicing early CT-PET for diagnostic purposes between February 2007 and October 2018. Of 127 consecutive patients who underwent CT-PET, SUVs up than 4, were found in 84 patients of which 20 were affected by PTLDs, seven patients were affected by chronic non neoplastic inflammatory diseases, the remainder were affected by other neoplasms. The favorable effect of physical activity programs on cardiorespiratory and psychomotor function occur in all patients. In conclusion, CT-PET at the first doubts about the possibility of the development of neoplasms has allowed a diagnosis and then a treatment more quickly. Education in behavioral norms that improve the patient's quality of life is necessary.

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Cancer- and non-cancer related chronic pain: from the physiopathological basics to management

Cited by 30 publications

References 53 publications

Endoscopic Treatment and Pulmonary Rehabilitation for Management of Lung Abscess in Elderly Lymphoma Patients

Endoscopic Treatment and Pulmonary Rehabilitation for Management of Lung Abscess in Elderly Lymphoma Patients

An Anecdotal Case Report of Chronic Lymphatic Leukemia with del(11q) Treated with Ibrutinib: Artificial Nourishment and Physical Activity Program

Post-Transplant Lymphoproliferative Diseases in the Elderly after Cardiac Transplantation: The Diagnostic Role of [18f] FDG-PET With Co-Registered CT and the Effect of Sports Activity Rehabilitation Program

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