Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: A double-blind, randomized pilot study

Brenner, Ronald; Azbel, Vadim; Madhusoodanan, Subramoniam; Pawłowska, Monika

doi:10.1016/s0149-2918(00)89010-4

Cited by 152 publications

(81 citation statements)

References 13 publications

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“…Brenner and colleagues [28] compared St. John's Wort, 900 mg/d, versus sertraline 75, mg/d, in 30 depressed subjects for 6 weeks. St. John's Wort yielded a 47% response rate and sertraline a 40% response rate.…”

Section: Efficacymentioning

confidence: 99%

Update and Critique of Natural Remedies as Antidepressant Treatments

Mischoulon

2007

Psychiatric Clinics of North America

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Section: Efficacymentioning

confidence: 99%

Update and Critique of Natural Remedies as Antidepressant Treatments

Mischoulon

2007

Psychiatric Clinics of North America

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“…The action of SJW has been well characterized in direct comparisons with leading antidepressant medications [35][36][37]. In a randomized controlled double-blind trial, 70 patients suffering from mild-to-moderate depression received one tablet of either SJW extract or fluoxetine twice a day for 6 weeks.…”

Section: Hypericum Perforatum (St John's Wort)mentioning

confidence: 99%

“…The conclusion of that study is that SJW was therapeutically equivalent to fluoxetine and is therefore a reasonable alternative to synthetic antidepressants. Hypericum extract has similarly been tested and showed an efficacy similar to that of sertraline in the treatment of mild-to-moderate depression in a small group of outpatients [36]. Efficacy and tolerability of SJW was also compared with imipramine and was equivalent to that of the drug in treating mild-to-moderate depression.…”

Section: Hypericum Perforatum (St John's Wort)mentioning

confidence: 99%

Complementary and Alternative Medical Treatment for Depression

Bongiorno¹

2005

Biology of Depression

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As the mainstream medical world is confronted with the dramatic increases in the utilization of complementary and alternative medicine (CAM) therapies, much is unknown regarding how to adequately consider these alternative treatments. There is little scientific justification to support the use of the vast array of alternative options, but these treatments are readily available to the public and CAM professionals. The public has been choosing to use dietary supplements, which has driven the increased utilization of CAM treatments in the past decade. This chapter discusses CAM treatments for major depression, but the primary focus is on dietary supplements. It is important to discuss how CAM clinicians ascertain that alternative treatment modalities are appropriate and then ascertain factors/symptoms in depressive illness that are most relevant when choosing from a myriad of treatment options available. It is important to mention that a substantial portion of the public has been utilizing dietary supplements without consulting CAM or non-CAM clinicians.

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“…In many countries, as well in Serbia Hypericum perforatum is traditionally used for the treatment of several diseases such as skin wounds, eczema, burns, inflammatory and psychological disorders. Furthermore, several clinical studies provide evidence that this herb is as effective as conventional synthetic antidepressants (Brenner et al, 2000;Schrader, 2000).…”

Section: Introductionmentioning

confidence: 99%

Cadmium, Mercury and Lead inHypericum perforatumL. collected in Western Serbia

Đurović

Bulat

Buha

et al. 2013

E3S Web of Conferences

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Abstract. Wild population of Hypericum perforatum growing in Western Serbia was analyzed for the content of important environmental pollutants cadmium, mercury and lead. Metal contents were determined by inductively coupled plasma optical emission spectrometry. Obtained results showed that levels of mercury and lead were under while cadmium concentrations exceeded limits recommended for medicinal plants. High levels of cadmium in investigated plants can be the result of soil enriched with cadmium as well as the ability of Hypericum perforatum to accumulate cadmium.

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Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: A double-blind, randomized pilot study

Cited by 152 publications

References 13 publications

Update and Critique of Natural Remedies as Antidepressant Treatments

Update and Critique of Natural Remedies as Antidepressant Treatments

Complementary and Alternative Medical Treatment for Depression

Cadmium, Mercury and Lead inHypericum perforatumL. collected in Western Serbia

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