Update and Critique of Natural Remedies as Antidepressant Treatments

Mischoulon, David

doi:10.1016/j.psc.2006.12.003

Cited by 26 publications

(13 citation statements)

References 92 publications

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“…Many natural products have distinctive smells or tastes (eg, valerian), or unique side effects (eg, St. Johns’ wort), which risk early patient unblinding. 51,52 Designing placebos with similar smells or tastes to the natural product under study can be complicated but is important.…”

Section: Potential Drug Interactions Between Prescription Medicationsmentioning

confidence: 99%

“…Different manufacturers have different methods for extracting and preparing the remedy from the herb or plant, and this may produce different proportions of active ingredients. 52 Therefore, conclusions drawn from a clinical trial of a herbal product may need to be interpreted with caution, particularly regarding dosing and toxic effects.…”

Section: Potential Drug Interactions Between Prescription Medicationsmentioning

confidence: 99%

See 1 more Smart Citation

Building an Evidence Base in Complementary and Integrative Healthcare for Child and Adolescent Psychiatry

Edwards

Mischoulon

Rapaport

et al. 2013

Child and Adolescent Psychiatric Clinics of North America

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Section: Potential Drug Interactions Between Prescription Medicationsmentioning

confidence: 99%

Section: Potential Drug Interactions Between Prescription Medicationsmentioning

confidence: 99%

Building an Evidence Base in Complementary and Integrative Healthcare for Child and Adolescent Psychiatry

Edwards

Mischoulon

Rapaport

et al. 2013

Child and Adolescent Psychiatric Clinics of North America

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“…Hypericin, one of the main active components in Hypericum perforatom decreases serotonin receptor density, inhibits production of interleukine 6,1β by monocyte, resulting in a decrease in releasing corticotrophin hormone thus dumpening production of cortisol. Hypericin may also inhibit reuptake of serotonin, norepinephrine and dopamine and may thus result in reduced expression of beta adrenoreceptores and increased density of serotonin receptors .Hypericin may also have affinity to GABA receptors (11). …”

Section: Introductionmentioning

confidence: 99%

“…In one study, about 2.4% of patients mentioned allergic reaction and gastrointestinal complains. Only 1.5% of patients stopped taking the drug, because of side effects (11). Orthostatic hypotension is common with TCAs and related drugs, and is not reported as a significant adverse effect of St. Johns Wort (16).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Pharmaceutical Products of St. John’s Wort Efficacy Added on Tricyclic Antidepressants in treating Major Depressive Disorder: A Double Blind Randomized Control Trial

Pakseresht

Boustani

Azemi

et al. 2012

Jundishapur J Nat Pharm Prod

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BackgroundMajor depressive disorder (MDD) is the most common disorder in our community. Hypericum perforatumm, is a herb with a long application history in treating depression. A controlled study to evaluate the effects of this herbal medicine in Iran did not exist.ObjectivesThis study aimed to assess the effect of Hypericum perforatom (perforan), in combination with tricyclic antidepressants in MDD treatment.Materials and MethodsThe present study was a placebo-controlled double blind randomized clinical trial including 40 patients with major depressive disorder who referred to Psychiatric Clinic and Golestan Hospital in 2011. Patients were randomly distributed in 4 blocks with 10 patients in each. 5 out of 10 patients took medicine (group I) and the others received placebo (group II).ResultsAfter six weeks, both groups indicated some improvement, there was also a significant degree of recovery in the perforan group (P = 0.04).ConclusionsThe results of the current study suggested that combinations of St. John’s Wort and tricyclic antidepressants compared to tricyclic antidepressants alone had significant effect on mild to moderate depression improvement. According to the numerous side effects of antidepressants, their continuous use was not well tolerated. There is a strong global tendency to use herbal medicines. Hypericum perforatom (St. John’s Wort) is one of the best types of unapproved MDD treatments. Also, the most common reason to discontinue antidepressant treatments is their sexual side effects. None of the patients in the two groups had complained about sexual side effects which was consistent with other studies and it was an advantage of using this herbal medicine. Perforan group had improved in quality of sleep and the increase of energy. This improvement had not been reported in previous studies. Sleep problems are common complications of specific serotonin reuptake inhibitors (SSRIs).

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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression

McKenzie

Kaufman

et al. 2009

Recent Advances in Plant Biotechnology

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Update and Critique of Natural Remedies as Antidepressant Treatments

Cited by 26 publications

References 92 publications

Building an Evidence Base in Complementary and Integrative Healthcare for Child and Adolescent Psychiatry

Building an Evidence Base in Complementary and Integrative Healthcare for Child and Adolescent Psychiatry

Evaluation of Pharmaceutical Products of St. John’s Wort Efficacy Added on Tricyclic Antidepressants in treating Major Depressive Disorder: A Double Blind Randomized Control Trial

The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression

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