Comparison of amantadine and rimantadine for prevention of type A (Russian) influenza

Quarles, John; Couch, Robert B.; Cate, Thomas R.; Goswick, Claude

doi:10.1016/0166-3542(81)90003-6

Cited by 32 publications

(19 citation statements)

References 16 publications

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“…This finding and the observation that the most troublesome side effects appeared during the first 10 days of prophylaxis are consistent with those results reported in controlled trials involving young, healthy subjects in both the Soviet Union (9) and the United States (3,5,16,11,12), and suggest, in spite of the small number of participants, that our monitoring system had sufficient specificity and sensitivity to detect bona fide adverse reactions. Nevertheless, we also found that such reactions were transient and only seldom considered clinically important, providing preliminary evidence that RH can be relatively well tolerated in selected elderly patients.…”

Section: B_supporting

confidence: 79%

Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes

Patriarca¹,

Kater²,

Kendal³

et al. 1984

Antimicrob Agents Chemother

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We evaluated the safety of rimantadine hydrochloride (RH) prophylaxis in a double-blind, placebocontrolled trial in three nursing homes during a community epidemic of influenza A (H3N2). Although daily monitoring of the 35 participants revealed an association between RH administration (100 mg twice a day) and the development of nausea and anxiety (P < 0.05), these and other potential side effects were transient and were rarely considered to be clinically significant. Serum RH levels measured at the end of the trial (mean, 1,159 ng/ ml) were nearly three times higher than those measured previously in younger individuals, suggesting that lower dosages may be indicated for the elderly.

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Section: B_supporting

confidence: 79%

Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes

Patriarca¹,

Kater²,

Kendal³

et al. 1984

Antimicrob Agents Chemother

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“…Alsons was that studies of the effects of amantadine prophylaxis on though such viruses might represent naturally resistant variants, influenza infections [16][17][18][19][20] indicate that subclinical infections we assumed that resistant influenza variants are not present at the account for about one-third of infections. Since not every infection time the epidemic is recognized.…”

Section: Modeling An Outbreakmentioning

confidence: 99%

Emergence of Drug Resistance during an Influenza Epidemic: Insights from a Mathematical Model

Stilianakis¹,

Perelson²,

Hayden³

1998

Journal of Infectious Diseases

116

109

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A model was developed for the emergence of drug-resistant influenza viruses during a closed population influenza epidemic that occurs in a single wave. The model was used to consider several treatment and chemoprophylaxis strategies and to determine their effects on the spread of the infection. The model predicts frequent emergence and transmission of drug-resistant viruses with certain treatment scenarios. According to the model, chemoprophylaxis of susceptible persons (without treatment of those who are symptomatic) may be the best way to reduce the force of an epidemic and to keep development of drug resistance low. The model predictions indicate that the relative transmissibility of resistant variants compared with wild type virus and the choice of the treatment or chemoprophylaxis strategy can be decisive for the spread of drug-resistant viruses, a feature that may be crucial in a pandemic.

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“…Insufficient data Hess, 1982 Not available to read in English Peters et al, 1989 Not a randomised controlled trial Plesnik et al, 1977 Not available to read in English Quarles et al, 1981 Not in line with licensed indications Quilligan et al, 1966a Not in line with licensed indications -dosage not established in children Quilligan et al, 1966 Not available to read in English Schapira et al, 1971 Not in line with licensed indications Schilling et al, 1998 Not in line with licensed indications Shinjoh et al, 2004 Not available to read in English Smorodintsev et al, 1972 Not available to read in English …”

Section: Appendixmentioning

confidence: 99%

Amantadine, oseltamivir and zanamivir for the prophylaxis of influenza (including a review of existing guidance no. 67): a systematic review and economic evaluation

Tappenden¹,

Rw²,

Cooper³

et al. 2009

Health Technol Assess

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Comparison of amantadine and rimantadine for prevention of type A (Russian) influenza

Cited by 32 publications

References 16 publications

Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes

Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes

Emergence of Drug Resistance during an Influenza Epidemic: Insights from a Mathematical Model

Amantadine, oseltamivir and zanamivir for the prophylaxis of influenza (including a review of existing guidance no. 67): a systematic review and economic evaluation

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