Comparison of alterations in the histamine-diamine oxidase system during acute intestinal ischaemia in pigs, dogs and rabbits: Evidence for a uniform pathophysiological mechanism?

Abstract

Among various vasoactive substances histamine was also suggested to induce circulatory arrest following superior mesenteric artery occlusion. Thus the involvement of the histamine-diamine oxidase system was studied in intestinal ischaemia using three animal species. In pigs, dogs and rabbits aminoguanidine, the specific inhibitor of diamine oxidase, shortened the survival time after mesenteric infarction. Under these conditions the diamine oxidase activity in the intestinal wall was reduced in animals treated by saline whereas the histamine content was not altered significantly. Plasma histamine levels were increased considerably in the portal vein of pigs during the revascularization period if the animal were pretreated by aminoguanidine. Similar findings were obtained in dogs. It was concluded that in all three species investigated the diamine oxidase protects the organism against the deleterious effects of at least one of its vasoactive substrates-histamine.

Localization and Changes of Diamine Oxidase During Cardiopulmonary Bypass in Rabbits

“…DAO functions as a regulator in rapidly proliferating tissue by deaminating these polyamines [4]. On the other hand, DAO has been reported to protect the organism against the deleterious effects of at least one vasoactive amine, histamine, after intestinal ischemia-reperfusion [22]. Elevated SSAO activity, which is observed in diabetic states, has been associated with reduced elasticity of arteries [23]; congeners of DAO may have yet other actions.…”

Effects of aminoguanidine on pre- and post-irradiation regional cerebral blood flow, systemic blood pressure and plasma histamine levels in the primate

“…Thus, using a paradigm that provoked a massive release of endogenous HA, we confirmed the observations of others [21] who showed that AG augmented the levels of HA given to dogs. In dogs and other species, AG shortened survival times following induction of intestinal ischemia [22,23], presumably by extending the duration of histamine's deleterious effects.…”

N-methyl-N-formylhydrazine: A toxic and mutagenic inhibitor of the intestinal diamine oxidase

“…At least it was found by KUSCHE et al [7,8] that aminoguanidine following mesenteric infraction increased the plasma histamine levels and aggravated severely the development of shock in rabbits, dogs and pigs. This effect could be reversed by histamine receptor antagonists.…”