Comparison of allele frequency for HLA-DR and HLA-DQ between patients with ECC and caries-free children

Bagherian, Ali; Nematollahi, Hossein; Afshari, Jalil Tavakol; Moheghi, Nasrin

doi:10.4103/0970-4388.40316

Cited by 29 publications

(28 citation statements)

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“…However, it did not provide high resolution genotyping as the antigens tested were determined by immunological reactions and not direct DNA sequencing. Bagherian et al [2008] also reported that the DR4-positive subjects younger than 5 years were 10 times more likely to develop early childhood caries than their negative counterparts. In the same way, Yildiz et al [2009] found that HLA-DRB1 * 04 and -DRB1 * 07 frequencies were significantly higher in the DMFT 6 1 group as compared with the DMFT = 0 group.…”

Section: Discussionmentioning

confidence: 97%

“…Associations between dental caries and the HLA region were obtained in both animal [Niiyama et al, 1987;Kurihara et al, 1991;Suzuki et al, 1998] and human studies [Lehner et al, 1981;Acton et al, 1999;Altun et al, 2008;Bagherian et al, 2008;Yildiz et al, 2009]. In the study conducted by Lehner et al [1981] the genetic predisposition towards caries was found to be positively associated with HLA-DR4 antigens and negatively with HLA-DRw6-related antigens.…”

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confidence: 90%

“…Recent studies have shown a relationship between HLA and increased risk for dental caries and higher levels of cariogenic bacteria in individuals [Acton et al, 1999;Altun et al, 2008;Yildiz et al, 2009]. Bagherian et al [2008] recommended HLA-DRB1 * 04 detection as a molecular marker for early diagnosis of early childhood caries.…”

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confidence: 99%

“…The HLA loci are part of the genetic region known as the major histocompatibility complex, which encodes polymorphic class I, II and III molecules that play a major role in antigen processing and presentation to the T-cell receptor, which is crucial for the cell interactions in cell-mediated immunity [Altun et al, 2008]. Therefore, differences in HLA molecules can cause variations in the immune response to microorganisms, such as Streptococcus mutans , and may influence the individual's susceptibility to dental caries [Bagherian et al, 2008]. HLA-DR and -DQ gene polymorphism, which results in different amino acid residues, will affect not only the recognition of the peptide by the T-cell receptor but also the interaction between the T-cell receptor and HLA molecules.…”

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confidence: 99%

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Association of Dental Caries with HLA Class II Allele in Brazilian Adolescents

Valarini

Maciel²,

Moura³

et al. 2012

Caries Res

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The purpose of this study was to evaluate the association between the frequencies of DR and DQ HLA class II alleles and the prevalence of dental caries in Brazilian adolescents. The study sample consisted of 164 adolescents aged 15– 19 years. For the assessment of caries experience the DMFT index was used, according to World Health Organization criteria. DNA samples of the adolescents were extracted from oral mucosa cells. The amplification of the alleles HLA-DR and HLA-DQ was carried out by polymerase chain reaction with sequence-specific primers (PCR-SSP). The products of PCR-SSP were electrophoresed and analyzed in agarose gel. Statistical analysis was performed using simple and multiple logistic regression to test the association between the adolescents’ caries experience and the presence of HLA-DR and -DQ alleles. Sociodemographic covariates were included in the model. The significance level for all analyses was p < 0.05. The prevalence of caries was 60.4% and the mean DMFT was 2.41 ± 2.53. Adolescents positive for HLA-DQ2 allele were less likely to have dental caries than their counterparts who were negative for this allele (OR = 0.33, CI 0.16–0.66), and those whose mothers presented low levels of education were 2.01 (CI 1.02–3.97) times more likely to have dental caries. There was no statistical difference between HLA-DR4, -DQ4, -DQ5, -DQ6 and dental caries. Our data provide evidence that genes within the MHC, especially the DQ2 group, may influence susceptibility to dental caries in Brazilian adolescents.

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Section: Discussionmentioning

confidence: 97%

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confidence: 90%

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confidence: 99%

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confidence: 99%

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Association of Dental Caries with HLA Class II Allele in Brazilian Adolescents

Valarini

Maciel²,

Moura³

et al. 2012

Caries Res

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“…Other authors noticed the genes from MHC complex, especially DR4 and DR3 in persons with a high level of S. mutans in the oral cavity [19]. De Vries et al [20], in turn, discovered no relation between caries incidence and the type of HLA DR.…”

Section: Impact On Host Response To Oral Bacteriamentioning

confidence: 98%

Genetic Aspects of Dental Caries

Kobierska-Brzoza¹,

Kaczmarek²

2016

Dent. Med. Probl.

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Dental caries still remain one of the most prevalent infectious diseases, affecting populations and individuals unequivocally. It is observed that people with similar behavioral risk present different caries rates. Susceptibility to caries results from both the host and environmental factors that complement each other and may result in increased incidence of caries or greater resistance to it. Numerous studies of twins, families and animal models initiated in the early decades of the previous century provided strong evidence for the genetic component of dental caries development. The succeeding research, identifying specific genes and genetic markers and confirming the genetic correlation of dental caries, explained the reasons behind the greater susceptibility to caries in some diseases like Epidermolysis bullosa. Many inherited determinants are well established. The most recognizable are the structure of the hard dental tissue, tooth morphology including depth of occlusal fissures and surface characteristic of the enamel, time of eruption, alignment of the teeth in dental arches, flow rate of the saliva and its constituents, immunologic response to cariogenic microorganisms in oral cavity. An important role is also played by inherited thresholds for tastes and smells, which affect taste preferences and thus dietary habits and activity of specific enzymes participating in regulation processes on various stages of development and subsequent physiologic functioning of the organism. The knowledge of genetic basis of caries will enable us to identify high-risk groups and provide them with targeted screening, preventive measures and interventional strategies (Dent. Med. Probl. 2016, 53, 3, 413-418).

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