Association of Dental Caries with HLA Class II Allele in Brazilian Adolescents

Valarini, Natália; Maciel, Sandra Mara; Moura, Sandra Kiss; Frederico, Regina Célia Poli

doi:10.1159/000341188

Cited by 23 publications

(16 citation statements)

References 42 publications

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“…An extensive search of the literature showed that only one disease is partially ‘protected' by an HLA-DQ, CD-predisposing haplotype (DQ2), which is dental caries. A recent Brazilian study showed that adolescents positive for the HLA-DQ2 allele were less likely to have dental caries than their counterparts who were negative for this allele (OR = 0.33, CI 0.16-0.66) [30]. Nothing was found about disease protection induced by the HLA-DQ8 haplotype.…”

Section: The Geoepidemiology Of Gluten Consumption and Hla Cd-predispmentioning

confidence: 99%

World Perspective and Celiac Disease Epidemiology

Catassi

Gatti

Lionetti

2015

Dig Dis

104

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In Europe and the USA, the mean frequency of celiac disease (CD) in the general population is approximately 1%, with some regional differences, the reasons for which remain elusive. A similar disease prevalence has been found in other countries mostly populated by individuals of European origin, e.g. Australia and Argentina. In Western countries, a true rise in overall CD prevalence of CD has been documented. CD is a common disorder in North Africa, the Middle East and India; however, the diagnostic rate is low in these countries due to low availability of diagnostic facilities and poor disease awareness. The highest CD prevalence in the world (5.6%) has been described in an African population originally living in Western Sahara, the Saharawi, of Arab-Berber origin. The reasons for this high CD frequency are unclear but could be primarily related to recent dietary changes and genetic factors, given the high level of consanguinity of this population. Further studies are needed to quantify the incidence of the celiac condition in apparently ‘celiac-free' areas such as Sub-Saharan Africa and the Far East. In many developing countries, the frequency of CD is likely to increase in the near future given the diffuse tendency to adopt Western, gluten-rich dietary patterns. As most cases currently escape diagnosis all over the world, an effort should be made to increase the awareness of CD polymorphism. A cost-effective case-finding policy and new strategies of mass CD screening could significantly reduce the morbidity and mortality associated with untreated disease. The current high prevalence of CD is just the last link in a chain of events started about 10,000 years ago after wheat domestication and diffusion from the Middle East. We hypothesize different mechanisms to explain the so-called evolutionary celiac paradox of co-localization of gluten consumption and HLA CD-predisposing genotypes.

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Section: The Geoepidemiology Of Gluten Consumption and Hla Cd-predispmentioning

confidence: 99%

World Perspective and Celiac Disease Epidemiology

Catassi

Gatti

Lionetti

2015

Dig Dis

104

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“…Accordingly, several studies in humans have indicated that polymorphisms in genes involved in enamel formation [Patir et al, 2008;Kang et al, 2011;Shimizu et al, 2012;Tannure et al, 2012;Saha et al, 2015], saliva composition [Anjomshoaa et al, 2015;Sengul et al, 2016], and immune response [Bagherian et al, 2008;Azevedo et al, 2010;Valarini et al, 2012;Fine et al, 2013], including DEFB1 [Ozturk et al, 2010;Krasone et al, 2014;Yildiz et al, 2016], play a role in caries susceptibility.…”

mentioning

confidence: 99%

Genetic Polymorphisms in DEFB1 and miRNA202 Are Involved in Salivary Human β-Defensin 1 Levels and Caries Experience in Children

Lips

Antunes²,

Antunes³

et al. 2017

Caries Res

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The antimicrobial peptides human β-defensins (hBDs) are encoded by β-defensin genes (DEFBs) and are possibly involved in caries susceptibility. In this study we aimed (1) to investigate the relationship between salivary hBDs and caries and (2) to evaluate the association of genetic polymorphisms in DEFB1 and microRNA202 (miRNA202) with salivary levels of hBDs and caries experience. Two data sets were available for this study, totalizing 678 Brazilian children. Dental examination and saliva collection were performed in all included children. The salivary level for hDB1, hBD2, and hBD4 was assessed by ELISA sandwich technique in 168 children. The DNA was extracted from saliva, and polymorphisms in DEFB1 and miRNA202 were analyzed by real-time PCR. Statistical analysis was performed to investigate the associations between caries experience, hBD salivary level, genotype, and allele distribution, with an alpha of 0.05. The hBD1 level was significantly higher in caries-free children (p < 0.0001). The miRNA202 was associated with a lower level of salivary hBD1 (p < 0.05). Also, the polymorphic distribution of miRNA202 was associated with caries (p = 0.006). The polymorphisms in DEFB1 were not associated with hBD salivary level and caries experience (p > 0.05). In conclusion, our results indicate that genetic polymorphism in miRNA202 is involved in hBD1 salivary level as well as caries experience in children.

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“…(MBL2) , matrix metalloproteinase (MMP) , tissue inhibitor of metalloproteinases 2 (TIMP2) , and human leucocyte antigen (HLA serotype DQ2) genes have been shown to be associated with the development of dental caries in a number of populations, including Caucasian, South American, European and Chinese individuals [Acton et al, 1999;Ozawa et al, 2001;Eisen and Minchinton, 2003;Ezekowitz, 2003;Bouwman et al, 2006;Bagherian et al, 2008;Katz et al, 2009;Shimada et al, 2009;Yildiz et al, 2009;Tannure et al, 2012;Letra et al, 2012b;Olszowski et al, 2012;Valarini et al, 2012;Yang et al, 2013].…”

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confidence: 99%

Association of <b><i>MBL2</i></b> Gene Polymorphism with Dental Caries in Saudi Children

Alyousef¹,

Borgio

AbdulAzeez

et al. 2016

Caries Res

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The high prevalence of dental caries in children worldwide is a major oral health problem which requires early intervention. Dental caries is mainly caused by the action of acids produced by bacteria in addition to many other factors. Recent genetic studies have reported that a number of genes are associated with the susceptibility to dental caries. The majority of these genes are associated with inflammation, increased susceptibility to infection, and dentine matrix formation. Using the TaqMan assay and direct DNA sequencing, the prevalence of 6 single-nucleotide polymorphisms (SNPs) in MMP9, MBL2, MMP2, and TIMP2 genes was determined in 102 children with caries and in 100 age-matched caries-free controls. Out of the 6 SNPs tested in the 4 selected genes, only rs11003125 in the MBL2 gene was shown to be associated with a high prevalence of caries in our cohort. In addition, haplotype analysis of the 6 SNPs tested revealed that certain haplotypes, namely GT of rs11003125G and rs7501477T and GT of rs7096206G and rs7501477T, were found to be associated with a high prevalence of dental caries in our cohort, while haplotype AG of rs17576A and rs7501477G was found to have a protective effect against dental caries. In conclusion, the data indicate that rs11003125 in the MBL2 gene was shown to be associated with a high prevalence of caries in our cohort, and 2 haplotypes are also involved in the increased susceptibility to dental caries.

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Association of Dental Caries with HLA Class II Allele in Brazilian Adolescents

Cited by 23 publications

References 42 publications

World Perspective and Celiac Disease Epidemiology

World Perspective and Celiac Disease Epidemiology

Genetic Polymorphisms in DEFB1 and miRNA202 Are Involved in Salivary Human β-Defensin 1 Levels and Caries Experience in Children

Association of <b><i>MBL2</i></b> Gene Polymorphism with Dental Caries in Saudi Children

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