Comparison of adiponectin, leptin and leptin to adiponectin ratio as diagnostic marker for metabolic syndrome in older adults of Chinese major cities

Zhuo, Qin; Wang, Zhiqiang; Fu, Ping; Piao, Jianhua; Tian, Yuan; Xu, Jie; Yang, Xiaoguang

doi:10.1016/j.diabres.2008.12.019

Cited by 84 publications

(85 citation statements)

References 38 publications

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“…Moreover, leptin-to-adiponectin ratio has been suggested to be a better marker of cardiovascular disease and type 2 diabetes risk than adiponectin concentration alone 9,10 . In this study, this ratio was unchanged in response to the MedDiet in both sexes, suggesting that the decrease in adiponectin concentration found in response to the MedDiet in men may have, overall, a rather mild negative impact on cardiovascular health.…”

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confidence: 99%

“…In the case of leptin, mixed results have been obtained, some studies observed that a high leptin concentration is a predictor of coronary events and type 2 diabetes independently of adiposity 5,6 while others showed that the association between leptin concentrations and these major chronic diseases is largely explained by concomitant variations in body weight or BMI 7,8 . It has been recently suggested that the leptin-to-adiponectin ratio could be a better marker of cardiometabolic alterations and insulin resistance than adiponectin or leptin alone 9,10 .…”

Section: Introductionmentioning

confidence: 99%

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Effects of the traditional Mediterranean diet on adiponectin and leptin concentrations in men and premenopausal women: do sex differences exist?

et al. 2014

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A bstract Background/O bjective: Most of the interventional studies have investigated the impact of the diet on adiponectin and leptin concentrations only in men or in women. Consequently, it is still unknown whether the consumption of a healthy diet influences in a sex-specific manner these adipocytokines.We examined sex differences in the effects of the Mediterranean diet (MedDiet) on adiponectin and leptin concentrations and determined whether changes in these adipocytokines are associated with changes in cardiovascular risk factors in both sexes.Subjects/Methods: Participants were 38 men and 32 premenopausal women (24-53y) with slightly elevated LDL-C concentrations (3.4-4.9 mmol/l) or total cholesterol/HDL-C and cardiovascular risk factors were measured before and after a 4-week fully-controlled isoenergetic MedDiet.Results: Adiponectin concentration decreased in response to the MedDiet, but this decrease reached statistical significance only in men (P<0.001 for men and P=0.260 for women; sex-by-time interaction, P=0.072). Adjustments for body weight or waist circumference did not change results obtained.Changes in adiponectin were positively associated with concomitant variations in HDL-C in men (r=0.52, P=0.003) and with variations in apo A-1 and insulin sensitivity as calculated by both HOMA-IS and Cederholm indices in women (respectively r=0.44, P=0.021; r=0.79, P<0.001 and r=0.47, P=0.020). The MedDiet had no impact on leptin and leptin-to-adiponectin ratio in both sexes.Conclusions: Results suggest sex difference in adiponectin response to the short-term consumption of the MedDiet, with only men experiencing a decrease. Also sex-specific patterns of associations between changes in adiponectin concentration and changes in cardiovascular risk factors were observed.

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confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of the traditional Mediterranean diet on adiponectin and leptin concentrations in men and premenopausal women: do sex differences exist?

et al. 2014

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“…[40][41][42] In our study, a decreased leptin : adiponectin ratio measured 7 days after AMI was related to future adverse events in patients with AMI. A lower leptin : adiponectin ratio may imply the existence of severe cardiac dysfunction and relatively insufficient tissue repair.…”

Section: Discussionmentioning

confidence: 88%

Impact of Adiponectin and Leptin on Long-Term Adverse Events in Japanese Patients With Acute Myocardial Infarction

Morita

Maeda

Kondo

et al. 2013

Circ J

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“…Adiponectin, an adipocyte-derived cytokine, modulates glucose metabolism and insulin resistance by the 5'-adenosine monophosphate activated kinase signaling pathway, and decreases also free fatty acid concentrations by stimulating fatty acid oxidation in muscle 22 . Thus, adiponectin may be a strong predictor for the occurrence of insulin resistance as well as a potential link between MS and its cardiovascular consequences 16,[23][24][25][26][27] .…”

Section: Discussionmentioning

confidence: 99%

“…It consists of three exons and two introns spanning a 16 Kb 12 . In this region, genome-wide scans have mapped a susceptibility locus for T2D, coronary artery disease, insulin resistance and MS [11][12][13][14][15][16] . Several single nucleotide polymorphisms (SNP) at this locus have been reported individually or in combination as haplotypes and the most commonly studied are rs17300539 (-11391G>A) and rs266729 (-11377C>G) in the promoter region and rs2241766 (+45T>G) and rs1501299 (276G>T) in exon 2 and intron 2, respectively 17 .…”

Section: Introductionmentioning

confidence: 99%

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2017

IJPSR

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Adiponectin has been schown to protect from insulin resistance, demonstrate anti-inflammatory and anti-atherosclerotic effects and be involved in the pathogenesis of metabolic syndrome (MS). We aimed to assess the association between serum adiponectin concentration, insulin resistance and various risk factors of MS and to investigate the relationship between the single nucleotide polymorphism (SNP) +45 T>G ( rs 2241766) in the adiponectin (ADIPOQ) gene and the risk of MS. 200 patients with MS and 250 healthy controls were enrolled in this study. The level of fasting serum insulin, glucose, and lipid levels were measured. Insulin resistance was estimated using homeostasis model of assessment for insulin resistance (HOMA-IR). Serum adiponectin levels were measured by enzyme-linked immunosorbent assay and the SNP +45 T>G in the ADIPOQ gene was performed by the polymerase chain reaction-restriction fragment length polymorphism method. MS patients had a significantly higher levels of HOMA-IR (p<0.001) and lower serum adiponectin concentrations (p<0.001) compared to controls. Multiple regression analysis showed that serum adiponectin levels was associated negatively with HOMA-IR (r=-0.307; p=0.001) and positively with high-density lipoprotein cholesterol (HDL-C) (r=0.369; p=0.000) in MS patients. In addition, there was no significant association between genotypes of rs 2241766 and the risk of MS. In conclusion, adiponectin is known to play key regulator of insulin sensitivity, endothelial function and lipid metabolism. Our findings confirm the associations of hypoadiponectinemia with MS and gave evidence that the SNP+45 T>G polymorphism in the gene of ADIPOQ is not associated with MS.

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Comparison of adiponectin, leptin and leptin to adiponectin ratio as diagnostic marker for metabolic syndrome in older adults of Chinese major cities

Cited by 84 publications

References 38 publications

Effects of the traditional Mediterranean diet on adiponectin and leptin concentrations in men and premenopausal women: do sex differences exist?

Effects of the traditional Mediterranean diet on adiponectin and leptin concentrations in men and premenopausal women: do sex differences exist?

Impact of Adiponectin and Leptin on Long-Term Adverse Events in Japanese Patients With Acute Myocardial Infarction

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