Comparison of acute subjective and heart rate effects of nicotine intake via tobacco smoking versus nasal spray

Perkins, Kenneth A.; Sexton, Joan E.; Reynolds, W. Ann; Grobe, James E.; Fonte, Carolyn; Stiller, Richard L.

doi:10.1016/0091-3057(94)90013-2

Cited by 73 publications

(56 citation statements)

References 10 publications

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“…There is an extensive literature indicating that acute tolerance develops to some effects of nicotine under a number of conditions, and chronic tolerance may persist for weeks or even years after abstinence from smoking (Benowitz et al, 1990;Fant et al, 1995;Perkins et al, 1991Perkins et al, , 1993Perkins et al, , 1994bPerkins et al, , 1995Perkins et al, , 2001Rosenberg et al, 1980;West and Russell, 1987). As discussed below, decreases in VAS subjective reports and cardiovascular measures after successive cigarettes are consistent with this interpretation.…”

Section: Tolerance To Nicotine's Biological and Subjective Effectssupporting

confidence: 67%

“…When the same dose of nicotine nasal spray (0, 7.5, or 15 mg/kg) was given every 30 min for 2 h, there was a dose-related decrease in Visual Analog Scale (VAS) ratings of 'Light Headed', 'Dizzy', and 'Head Rush' in response to a challenge dose of 30 mg/kg nicotine administered 30 min after the session (Perkins et al, 1993). However, repeated administration of nicotine nasal spray (10 or 20 mg/kg) once every 30 min for 2 h also produced increases in heart rate and ratings of 'Rush' and 'Dizzy' that paralleled increases in plasma nicotine levels (Perkins et al, 1994b). When subjects smoked their usual cigarette or a low-yield cigarette for B2.5 min once every 30 min for 2 h, increases in subjective ratings of 'Rush' and 'Dizzy' and heart rate also paralleled increases in plasma nicotine levels (Perkins et al, 1994b).…”

Section: Introductionmentioning

confidence: 99%

“…However, repeated administration of nicotine nasal spray (10 or 20 mg/kg) once every 30 min for 2 h also produced increases in heart rate and ratings of 'Rush' and 'Dizzy' that paralleled increases in plasma nicotine levels (Perkins et al, 1994b). When subjects smoked their usual cigarette or a low-yield cigarette for B2.5 min once every 30 min for 2 h, increases in subjective ratings of 'Rush' and 'Dizzy' and heart rate also paralleled increases in plasma nicotine levels (Perkins et al, 1994b). Increasing the interval between nicotine exposure (20 mg/kg nicotine spray every 30 min for 2 h) and a challenge dose of the same dose of nicotine suggested that acute tolerance to cardiovascular and some subjective effects persisted for at least 2 h (Perkins et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Smoking Successive Low- and High-Nicotine Cigarettes on Hypothalamic–Pituitary–Adrenal Axis Hormones and Mood in Men

Mendelson

Goletiani

Sholar

et al. 2007

Neuropsychopharmacol

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Smoking one cigarette produces rapid nicotine dose-related increases in hypothalamic-pituitary-adrenal (HPA) axis hormones, mood, and heart rate, but relatively little is known about the effects of smoking several cigarettes successively. Twenty-four healthy adult men who met Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria for nicotine dependence provided informed consent. After overnight abstinence from smoking, men smoked three low-or high-nicotine cigarettes for 4 min each at 60 min intervals. Samples for nicotine and hormone analysis, Visual Analog Scale (VAS) ratings of subjective effects and heart rate were collected at 4, 8, 12, 16, 20, 30, 40, and 50 min after each cigarette. After low-nicotine cigarettes, nicotine levels, adrenocorticotropin hormone, and heart rate did not increase significantly, cortisol and dehydroepiandrosterone decreased significantly, and positive VAS ratings were lower but parallel to ratings after high-nicotine cigarette smoking. After high-nicotine cigarettes, peak nicotine levels increased monotonically. HPA axis hormones increased after smoking, but peak levels did not differ significantly after successive high-nicotine cigarettes. Positive VAS ratings and heart rate increased after each high-nicotine cigarette, but peak levels were lower after smoking the second and third cigarette. 'Craving' decreased significantly after smoking both low-and high-nicotine cigarettes, then gradually increased during the 60 min interval between cigarettes. These data are consistent with clinical reports that the first cigarette after overnight nicotine abstinence is most salient. Tolerance to the subjective and cardiovascular effects of nicotine developed rapidly during repeated cigarette smoking, but nicotine-stimulated increases in HPA axis hormones did not change significantly.

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Section: Tolerance To Nicotine's Biological and Subjective Effectssupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Smoking Successive Low- and High-Nicotine Cigarettes on Hypothalamic–Pituitary–Adrenal Axis Hormones and Mood in Men

Mendelson

Goletiani

Sholar

et al. 2007

Neuropsychopharmacol

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“…This is interesting because previous research suggests that women are less responsive to the reinforcing properties of nicotine administered without exteroceptive smoking cues than men (Perkins, 1996). However, our in-session mood self-report results are consistent with the nicotine selfadministration studies that found women were less responsive than men to the hedonic effects of nicotine administered through nasal spray, in the absence of exteroceptive smoking cues (Perkins et al, 1994;Perkins et al, 1996;Perkins, 1996;Perkins, Donny, & Caggiula, 1999). The increase in deprived women's self-report of in-session negative mood found here may reflect increased reactance to the aversive sensory properties of the nicotine nasal spray compared to men.…”

Section: Discussionsupporting

confidence: 45%

Gender differences in affective response to acute nicotine administration and deprivation

Robinson

Cinciripini

Tiffany

et al. 2007

Addictive Behaviors

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Men and women may differ in their sensitivity to the mood-modulating properties of nicotine. Male and female adult smokers were exposed to four sessions crossing two nicotine deprivation conditions (12-hr deprived vs. nondeprived) with two drug conditions (nicotine vs. placebo nasal spray). Acoustic probes elicited startle eyeblink responses while viewing affective and cigaretterelated slides. In-session mood ratings were collected to gauge self-reported negative affect, positive affect, and craving. Nicotine nasal spray reduced startle amplitude in both men and women following 12-hr deprivation compared with smoking nondeprivation. During nondeprivation, nicotine nasal spray increased startle amplitude in women compared with placebo spray, whereas no difference was found for men. The startle results suggest that both men and women are responsive to the hedonic properties of nicotine.

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“…Nasal sprays have shorter latencies of action, with blood nicotine levels peaking within 5-10 minutes. 51,52 No difference in efficacy has been demonstrated between products.…”

Section: Nicotine Replacement Therapymentioning

confidence: 99%

Treatment of tobacco dependence: integrating recent progress into practice

Foll¹,

George²

2007

Canadian Medical Association Journal

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Smoking is currently responsible for the death of 1 in 10 adults worldwide, or about 5 million deaths each year. Half of the 650 million people who smoke today will eventually be killed by tobacco, 1 and this morbidity and mortality can be mostly avoided if people stop smoking. 2The prevalence of smoking varies greatly around the world. Over 4.5 million people are current smokers in Canada, representing 18% of the population aged 15 years and older.

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Comparison of acute subjective and heart rate effects of nicotine intake via tobacco smoking versus nasal spray

Cited by 73 publications

References 10 publications

Effects of Smoking Successive Low- and High-Nicotine Cigarettes on Hypothalamic–Pituitary–Adrenal Axis Hormones and Mood in Men

Effects of Smoking Successive Low- and High-Nicotine Cigarettes on Hypothalamic–Pituitary–Adrenal Axis Hormones and Mood in Men

Gender differences in affective response to acute nicotine administration and deprivation

Treatment of tobacco dependence: integrating recent progress into practice

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