Comparison of Acute Cardiovascular Effects of Cadmium and Captopril in Relation to Oxidant and Angiotensin Converting Enzyme Activity in Rats

Puri, V.N.; Saha, Sikha

doi:10.1081/dct-120022646

Cited by 20 publications

(8 citation statements)

References 17 publications

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“…The narrowing of capillary lumina contributes to the hypertension reported previously [38] in rats following cadmium intoxication. Hypertension may result from cadmium-induced changes in vasculature, the rennin-angiotensin system, or renal ion transport process.…”

Section: Resultsmentioning

confidence: 86%

Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

Mahran¹,

Osman²

2011

J Cytol Histol

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Section: Resultsmentioning

confidence: 86%

Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

Mahran¹,

Osman²

2011

J Cytol Histol

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“…So, it can be claimed that Cd +2 is not effective on HR. But there are also studies that state that Cd +2 increased (Puri 1997) or decreased HR (Carmignani and Boscolo 1984).…”

Section: Discussionmentioning

confidence: 93%

Determination of acute and chronic effects of cadmium on the cardiovascular system of rats

Ozturk

Büyükakıllı

Ballı

et al. 2009

Toxicology Mechanisms and Methods

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In this study, the systemic hemodynamics induced by acute and chronic cadmium (Cd+2) intoxication in the cardiovascular system of rats using thoracic electrical bioimpedance were examined and the acute and chronic effects of Cd+2 intoxication on the activities of antioxidant enzymes and malondialdehyde (MDA) were compared. Also, in this study, ultrastructural changes in the heart and aorta of rats were evaluated. Thirty-eight male Wistar albino rats were randomly divided into control, acute, and chronic groups. Chronic group was administered by oral gavage an aqueous solution of CdCl2 for 60 days, at dose of 15 mg Cd+2/kg/day. Acute group was administered by oral gavage an aqueous solution of CdCl2 with a single dose of 15 mg Cd+2/kg. Cadmium increased the stroke volume and cardiac output of rats in the chronic group, but did not change the heart rate significantly. Antioxidant enzymes activities and MDA level significantly increased in the chronic group. In ultrastructural examination, there were widespread degenerative changes in heart muscle cells of the chronic group but endothelial cells and smooth muscle cells in the aorta tissue samples had normal morphological features in all groups. All of the findings indicate that Cd+2 toxication can cause deformation in heart muscle cells due to an increase in free radicals and lipid peroxidation. Also, this study has confirmed that a long-term-Cd+2 exposure increased stroke volume (SV) and cardiac output (CO), but did not change the heart rate (HR).

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“…1,2) However, other epidemiological studies in Belgium produced evidence inconsistent with the hypothesis that environmental exposure to Cd leads to an increase in blood pressure and a higher prevalence of hypertension. 3,4) Although many reports have shown an increase in blood pressure in experimental animals treated parentally with Cd, 5,6) the effects of dietary administration of Cd over long periods and at low levels on blood pressure remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Effect of Magnesium Deficiency on Blood Pressure in Normal Rats Fed Cadmium

Nishiyama

Onosaka

Sakai

et al. 2005

JOURNAL OF HEALTH SCIENCE

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We attempted to further define the effects of an Mg-deficient diet on blood pressure in rats fed Cd for long periods. Twenty male Wistar rats were grouped according to four different diets: normal diet (N rats); normal diet supplemented with Cd at a dose of 50 µg/g of diet (N rats fed Cd); Mg-deficient diet (D rats); and Mg-deficient diet supplemented with Cd at a dose of 50 µg/g of diet (D rats fed Cd). Each diet was given for 60 days. N rats fed Cd developed a duration-limited increase in blood pressure: by day 60, increased blood pressure returned to the level seen in N rats. Mg deficiency lowered the Cd-induced increase in blood pressure and this response was more pronounced on day 60. A variety of independent blood pressure regulatory mechanisms was investigated. Although Mg deficiency tended to occur at lower concentrations of Cd and metallothionein in the heart of N rats fed Cd and the Cd concentration was less than 5 µg/g of tissue, Mg deficiency increased the Ca concentration in the hearts of N rats fed Cd while a decrease in urinary Na excretion and an increase in water retention were not observed. Diet-related toxic clinical signs in D rats fed Cd induced marked blush on the ears and fingers, indicating vasodilatation had occurred. These findings may have been a factor in the pronounced reduction in blood pressure seen.

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Comparison of Acute Cardiovascular Effects of Cadmium and Captopril in Relation to Oxidant and Angiotensin Converting Enzyme Activity in Rats

Cited by 20 publications

References 17 publications

Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

Determination of acute and chronic effects of cadmium on the cardiovascular system of rats

Effect of Magnesium Deficiency on Blood Pressure in Normal Rats Fed Cadmium

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