Comparison of a transfusion preparation of newly formed red cells and standard washed red cell transfusions in patients with homozygous β‐ thalassemia

Abstract

These data demonstrate that extension of the transfusion interval, and reduction in transfused iron, may be achieved in thalassemic patients by use of the Neocel system. These benefits are achieved, however, with substantial increases in donor exposure and in component preparation costs.

Transfusion of Neocytes Concentrate/Pooled Neocytes and Conventional Packed Red Blood Cells in Beta-Thalassemia Major Patients: A Comparative Study

“…41-48 days (average 45 days) over control group patients, in which it was 21-27 days (average 24.5 days). It is nearly the same as observed by Propper et al 1980 [16] and Collin A F et al 1994 [21] , 43 +/-4.5 days and 35-44.5 days respectively in their studies of neocytes transfusion.…”

“…As the transfusion intervals increased and numbers of transfusion (7 versus 12) decreased in study group than control group, so the observation is in accordance with previous study like Bertholey F et al 1990 [17] , Montoya AF et al 1993 [18] , Spanos T et al 1996 [19] and Collin A F et al 1994. [21] Extension of transfusion intervals observed in our study group patients was significant i.e. 41-48 days (average 45 days) over control group patients, in which it was 21-27 days (average 24.5 days).…”

“…The serum iron reduction was observed 5/12 X 100% =41.67% in study group in comparison to control group. Study done by Collin AF et al 1994 [21] have observed reduction of serum ferritin level by 19.05%. Prolongation of the life span of transfused young red blood cells, i.e.…”

“…If neocytes with an average 90 days lifespan are transfused instead of conventional packed red blood cells with an average 60 days lifespan (Half-life of neocyte is almost twice that of conventional red blood cell) to a beta-thalassemia major patient, then the time interval between two transfusions can be increased, incidences of transfusion related hazards and the chances of inducing haemosiderosis may be reduced by decreasing numbers of required red blood cells units transfusion as neocytes survive in the circulation longer than older cells and may reduce the total red blood cells requirement. [21] The inconvenience of pooled neocytes transfusion is exposure to a large number of donors.…”

Transfusion of neocytes concentrate/pooled neocytes in β-thalassemic patients

“…They occur due to decreased/absent synthesis of β globulin chains [1]. β-thalassemia major is an autosomal recessive genetic disorder, which is clinically; the most severe form and the affected child is dependent on regular blood transfusion for survival [2]. The current management of β-thalassemia major patient is based on regular transfusion of packed red cells and effective chelating therapy [3][4][5][6].…”