Comparison of a novel antigen detection test with reverse transcription polymerase chain reaction assay for laboratory diagnosis of SARS-CoV-2 infection

Cirit, Osman Sezer; Mutlu, Esvet; Sancak, Banu; Kocagoz, Tanil; Can, Özge; Çiçek, Candan; Sayıner, Ayça Arzu; Appak, Özgür; Uyar, Neval Yurttutan; Külah, Canan; Çiçek, Ayşegül Çopur; Özgümüş, Osman Birol; Altıntop, Yasemin Ay; Saatçi, Esma; Karslığil, Tekin; Zer, Yasemin; Özen, Nevgün Sepin; Çekın, Yeşim; Karahan, Zeynep Ceren; Evren, Ebru; Karakoç, Ayşe Esra; Orhan, Sultan Gülbahçe; Mutlu, Derya; Bozdemir, Tuğba; Çaycı, Yeliz Tanrıverdi; Çinar, Canberk; Taşbakan, Meltem; Mert, Merve; Çınar, Ece; Kutsoylu, Oya Özlem Eren; Kocagöz, Sesin; Ertürk, Ayşe; Çelik, İ̇lhami; Mete, Ayşe Özlem; Eneylı, Müge Günalp; Akdemir, Irem; Karakök, Taliha; İnan, Dilara; Atilla, Aynur; Taflan, Şevket Onur; Yörük, Kağan Etka

doi:10.1007/s15010-022-01832-9

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…Patients aged ≥20 years who were diagnosed with COVID-19 and required hospitalization were included in this study. The diagnosis was made using a polymerase chain reaction, antigen test, or loop-mediated isothermal amplification [15][16][17]. Meanwhile, patients who did not provide consent or whose close relatives did not provide consent; patients with other infections in addition to COVID-19; patients with end-stage heart failure defined as class IV according to the New York Heart Association Functional Classification [18], end-stage liver failure defined as Child-Pugh classification C [19], and any malignancy undergoing treatment; pregnant women; patients on their second admission for COVID-19; and patients accidentally diagnosed with COVID-19 through investigations of diseases requiring emergency therapeutic interventions were excluded.…”

Section: Patientsmentioning

confidence: 99%

Circulating Extracellular Vesicle Levels in Patients with Coronavirus Disease 2019 Coagulopathy: A Prospective Cohort Study

Iwasaki

Takei

Yamada

et al. 2023

JCM

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Coronavirus disease 2019 (COVID-19) is associated with coagulopathy. However, the underlying mechanisms are not completely understood. We evaluated the association between COVID-19 coagulopathy and extracellular vesicle (EV) levels. We hypothesized that several EV levels would be higher in COVID-19 coagulopathy patients than in non-coagulopathy patients. This prospective observational study was conducted in four tertiary care faculties in Japan. We enrolled 99 COVID-19 patients (48 with coagulopathy and 51 without coagulopathy) aged ≥20 years who required hospitalization, and 10 healthy volunteers; we divided the patients into coagulopathy and non-coagulopathy groups according to the D-dimer levels (≥1 μg/mL and <1 μg/mL, respectively). We used flow cytometry to measure the tissue-factor-bearing, endothelium-derived, platelet-derived, monocyte-derived, and neutrophil-derived EV levels in platelet-free plasma. The EV levels were compared between the two COVID-19 groups as well as among the coagulopathy patients, non-coagulopathy patients, and healthy volunteers. No significant difference was found in EV levels between the two groups. Meanwhile, the cluster of differentiation (CD) 41 + EV levels were significantly higher in COVID-19 coagulopathy patients than in healthy volunteers (549.90 [255.05–984.65] vs. 184.3 [150.1–254.1] counts/µL, p = 0.011). Therefore, CD41+ EVs might play an essential role in COVID-19 coagulopathy development.

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Section: Patientsmentioning

confidence: 99%

Circulating Extracellular Vesicle Levels in Patients with Coronavirus Disease 2019 Coagulopathy: A Prospective Cohort Study

Iwasaki

Takei

Yamada

et al. 2023

JCM

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“…is considered the gold standard method. There are also some rapid antigen test kits available for screening symptomatic and asymptomatic patients and their contacts [80].…”

Section: Sars-cov-2mentioning

confidence: 99%

Strategies to fight COVID-19: Beyond the difference between SARS-CoV-2 and Influenza virus

Lin¹,

Hequan²

2022

Int J Sex Reprod Health Care

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Background: Since the outbreak of COVID-19 emerged in Wuhan, China, in December 2019, the epidemic has spread worldwide and posed a great threat to society. Despite great achievements in COVID-19 research, few studies have focused on the similarities and differences between SARS-CoV-2 and influenza viruses. Results: Through a review of the literature on SARS-CoV-2 and influenza viruses, we found that influenza occurs every year, and influenza pandemics occur irregularly. The uncomplicated human influenza viruses primarily affect the larger airways and rarely the alveoli. However, SARS-CoV-2 mainly involves the deep airways and lungs and can cause DAD, leading to severe hypoxemia. In general, SARS-CoV-2 is no less infectious than the influenza virus. However, its destructive power to the lungs is no less than the avian influenza virus. There is currently no clinical vaccine and specific inhibitor against SARS-CoV-2. Conclusions: SASR-CoV-2 damages lung function more severely than the influenza virus, with higher morbidity, mortality, and severe disease rates. Controlling the source of infection, cutting off the route of transmission, and protecting susceptible populations are critical to the fight against SARS-CoV-2.

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“…Till now, Different methods have been used to diagnose this disease, including designing/applying complementary RNA sequences of the virus genome, antigens, and antibodies related to this virus [ 7 ]. The most important method of diagnosing COVID-19 in clinics and hospitals is the real-time reverse transcription-polymerase chain reaction (RT-PCR) [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Sandwich-like electrochemical aptasensing of heat shock protein 70 kDa (HSP70): Application in diagnosis/prognosis of coronavirus disease 2019 (COVID-19)

Negahdary

Hirata

Sakata

et al. 2023

Analytica Chimica Acta

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Comparison of a novel antigen detection test with reverse transcription polymerase chain reaction assay for laboratory diagnosis of SARS-CoV-2 infection

Cited by 7 publications

References 20 publications

Circulating Extracellular Vesicle Levels in Patients with Coronavirus Disease 2019 Coagulopathy: A Prospective Cohort Study

Circulating Extracellular Vesicle Levels in Patients with Coronavirus Disease 2019 Coagulopathy: A Prospective Cohort Study

Strategies to fight COVID-19: Beyond the difference between SARS-CoV-2 and Influenza virus

Sandwich-like electrochemical aptasensing of heat shock protein 70 kDa (HSP70): Application in diagnosis/prognosis of coronavirus disease 2019 (COVID-19)

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