Comparison of a new whole-body continuous-table-movement protocol versus a standard whole-body MR protocol for the assessment of multiple myeloma

ObjectiveTo determine which of four Dixon image types [in-phase (IP), out-of-phase (OP), fat only (FO) and water-only (WO)] is most sensitive for detecting multiple myeloma (MM) focal lesions on whole body MRI (WB-MRI) images.MethodsThirty patients with clinically-suspected MM underwent WB-MRI at 3 Tesla. Unenhanced IP, OP, FO and WO Dixon images were generated and read by four radiologists. On each image type, each radiologist identified and labelled all visible myeloma lesions in the bony pelvis. Each identified lesion was compared with a reference standard consisting of pre- and post-contrast Dixon and diffusion weighted imaging (read by a further consultant radiologist) to determine whether the lesion was truly positive. Lesion count, true positives, sensitivity, and positive predictive value were compared across the four Dixon image types.ResultsLesion count, true positives, sensitivity and confidence scores were all significantly higher on FO images than on IP images (p>0.05).DiscussionFO images are more sensitive than other Dixon image types for MM focal lesions, and should be preferentially read by radiologists to improve diagnostic accuracy and reporting efficiency.

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“…Furthermore, previous studies suggest that gradient echo imaging offers similar image quality spin echo imaging in MM. [16]…”

Section: Discussionmentioning

confidence: 99%

“…Acquisition times are similar to those for conventional gradient echo imaging and shorter than for spin echo imaging. [15,16] When reporting, the IP images can be viewed in a similar fashion to conventional T1-weighted images, whilst water and fat can be separately evaluated on WO and FO images.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic utility of whole body Dixon MRI in multiple myeloma: A multi-reader study

et al. 2017

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“…Advances in MR technique and technology, such as parallel acquisition techniques and continuous table movement, have allowed significant reductions in acquisition time while maintaining the image quality of whole-body MRI scans. 11 One of the fields that was among the earliest to explore the clinical applications of whole-body MRI was oncology because metastatic disease can occur in multiple widely distributed organ systems. 12 Whole-body MRI can also be used to evaluate pathology that affects large portions of a patient's muscular anatomy simultaneously, as is seen in many pediatric 13 and adult myopathies, inherited muscle disorders such as Duchenne's muscular dystrophy (DMD), 14 and delayed-onset muscle soreness (DOMS).…”

Section: Whole-body Mrimentioning

confidence: 99%

Advanced MRI Techniques for Muscle Imaging

Kalia

Leung

Sneag

et al. 2017

Semin Musculoskelet Radiol

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Advanced magnetic resonance imaging (MRI) techniques can evaluate a wide array of muscle pathologies including acute or chronic muscle injury, musculotendinous response to injury, intramuscular collections and soft tissue masses, and others. In recent years, MRI has played a more important role in muscle disease diagnosis and monitoring. MRI provides excellent spatial and contrast resolution and helps direct optimal sites for muscle biopsy. Whole-body MRI now helps identify signature patterns of muscular involvement in large anatomical regions with relative ease. Quantitative MRI has advanced the evaluation and disease tracking of muscle atrophy and fatty infiltration in entities such as muscular dystrophies. Multivoxel magnetic resonance spectroscopy (MRS) now allows a more thorough, complete evaluation of a muscle of interest without the inherent sampling bias of single-voxel MRS or biopsy. Diffusion MRI allows quantification of muscle inflammation and capillary perfusion as well as muscle fiber tracking.

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“…At the same time current data overall still shows inferiority of MRI for detection of lymph node metastases although current studies using diffusion-weighted MRI for whole body imaging demonstrate results comparable with PET-CT [121]. Further technical developments of this method using continuous table acquisition techniques allow further reduction of the total scan time to less than 30 minutes [122]. …”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Current oncologic concepts and emerging techniques for imaging of head and neck squamous cell cancer

Sadick,

Schoenberg,

Hoermann

et al. 2012

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 11:Doc08; ISSN 1865-1011

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Comparison of a new whole-body continuous-table-movement protocol versus a standard whole-body MR protocol for the assessment of multiple myeloma

Abstract: The new protocol allows a higher patient throughput and facilitates the depiction of extramedullary lesions. However, as long as vertebral fractures are not detectable, the protocol cannot be safely used for clinical routine without the acquisition of an additional sagittal sequence.

Cited by 17 publications

References 39 publications

Diagnostic utility of whole body Dixon MRI in multiple myeloma: A multi-reader study

Diagnostic utility of whole body Dixon MRI in multiple myeloma: A multi-reader study

Advanced MRI Techniques for Muscle Imaging

Current oncologic concepts and emerging techniques for imaging of head and neck squamous cell cancer

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