Comparison of 6-day progestagen treatment with Chronogest® CR and Eazi-breed™ CIDR® G intravaginal inserts for estrus synchronization in cyclic ewes

Fleisch, A; Werne, Steffen; Heckendorn, Félix; Hartnack, Sonja; Marion, P; Bollwein, Heinrich; Thun, R.; Janett, F.

doi:10.1016/j.smallrumres.2012.05.014

Cited by 22 publications

(26 citation statements)

References 23 publications

(33 reference statements)

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“…The short‐term P4 protocol induces better quality follicle than the long‐term protocol (12–14 days) which may induce an aged follicle with a prolonged lifespan. This finding is consistent with those of previous studies performed in goats (Dixon et al, ; Knights et al, ), ewes (Ataman et al, ; Fleisch et al, ; Ungerfeld & Rubianes, ; Ustuner, Gunay, Nur, & Ustuner, ) and deer (Fleisch et al, ) treated with P4 for 5 to 7 days (Viñoles et al, ). Additionally, CIDR can liberate P4 in limited concentrations for longer period than is endorsed for oestrous synchronization (Schoenian, ).…”

Section: Introductionsupporting

confidence: 92%

Efficacy of using previously used controlled internal drug release (CIDR) insert on the reproductive performance, hormone profiles and economic measures of sheep

Swelum

Saadeldin

Moumen

et al. 2018

Reprod Domestic Animals

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This study was conducted using 120 multiparous Awassi ewes during the breeding season to compare the effects of using previously used controlled internal drug release (CIDR) on the hormone profiles, reproductive performance and economic measures of ewes. Ewes were randomized to receive one of five previously used CIDR (previously used for 6, 12, 18, 24 or 30 days) or the new CIDR as a control for 6 days (CIDR6, CIDR12, CIDR18, CIDR24, CIDR30, and CIDR0 [control], respectively). Blood samples were collected on four occasions, at the time of CIDR insertion, after 3 days of insertion, and at the time of withdrawal and insemination. Serum estradiol (E2) and progesterone (P4) concentrations were measured. Timed insemination was performed 48 hr post-CIDR withdrawal. Pregnancy was diagnosed by ultrasonography 23 days after insemination and confirmed on day 35. The heat detection rate was significantly (p < 0.05) higher in the CIDR0 and CIDR6 groups than in the CIDR18 and CIDR30 groups. The total pregnancy rate and fecundity were significantly (p < 0.05) higher in the CIDR6 group than in other groups. P4 level was significantly (p < 0.05) higher in the CIDR0 group than in the CIDR30 group at the time of removal. At each time point, the E2 level was significantly (p < 0.05) higher in the CIDR6 group than at the other groups. The total variable cost, total cost, return and net profit were higher in the CIDR6 and CIDR0 groups than in the other groups. In conclusion, although previously used CIDRs are efficient at synchronizing oestrus in ewes, the duration of previously usage significantly affected the reproductive parameters and economic profit. CIDRs previously used for 6 days and new CIDRs provided the highest fertility and fecundity rates, besides return and net profit. Economically, it is not advisable to use CIDRs that previously used for 12 days or more.

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Section: Introductionsupporting

confidence: 92%

Efficacy of using previously used controlled internal drug release (CIDR) insert on the reproductive performance, hormone profiles and economic measures of sheep

Swelum

Saadeldin

Moumen

et al. 2018

Reprod Domestic Animals

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“…As a general principle, these effects of progesterone can be used in estrus synchronization protocols [46][47][48]. Medroxyprogesterone acetate (MAP), fluorogestone acetate (intravaginal sponge), melengestrol acetate, levonorgestrel, and intravaginal progesterone-releasing devices (CIDR and DICO) are used for estrus synchronization in sheep and goats [48][49][50][51][52][53][54][55].…”

Section: Use Of Progesterone In Estrus Synchronization In Small Ruminmentioning

confidence: 99%

“…High estrus rates and similar fertility rates were determined in sheep that applied short-term (6 days) CIDR-G or fluorogestone acetate (FGA, intravaginal sponge) [52].…”

Section: Use Of Progesterone In Estrus Synchronization In Small Ruminmentioning

confidence: 99%

Clinical Use of Progesterone and Its Relation to Oxidative Stress in Ruminants

Kuru¹,

Kükürt²,

Oral³

et al. 2018

Sex Hormones in Neurodegenerative Processes and Diseases

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Studies to determine the physiological effects and functions of progesterone started in the twentieth century. Progesterone is a steroid-structured hormone with 21 carbon atoms originating from cholesterol. The corpus luteum, formed after ovulation in ruminants, secretes progesterone, which plays a role in the continuity of the pregnancy. Progestagens can be used for estrus synchronization in cows and heifers. Similarly, they are used for estrus synchronization during the breeding season or outside the breeding season by taking advantage of the negative feedback effect of progesterone in small ruminants. It is applied for the treatment of embryonic deaths due to luteal insufficiency in cows with high milk yield. In anovulatory anestrus, exogenous progesterone applications can be very useful. Progesterone treatment contributes to the resolution of the anestrus by rearranging hypothalamic functions in cattle with follicular cysts. The oxidative stress index in the luteal phase, when progesterone is high in ruminants, is higher than in the follicular phase. In the critical period of pregnancy, a high index of oxidative stress-induced progesterone causes embryonic death. Factors that cause stress in high milk-yielding cows can affect the amount of progesterone synthesis by inhibiting luteal cell function due to excessive free radical production.

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“…Zur Berechnung der Abweichung der geschätzten von effektiven Trächtigkeitsdauer wurde eine Trächtigkeitsdauer von 150 Tagen angenommen (Fleisch et al, 2012 (Haibel, 1990;Fridlund et al, 2013). Bei der Bestimmung des Trächtigkeitsstatus war der positive prädiktive Wert sehr hoch (99.7 %), der negative prädiktive Wert jedoch deutlich geringer (82.8%) was wohl auf Schwierigkeiten bei der Erkennung von Frühgraviditäten zurückzuführen ist (Wilkins und Fowler 1984;Haibel, 1990;Youngquist und Threlfall, 2007;Gonazles-Bulnes et al, 2010).…”

Section: Bestimmung Der Genauigkeit Der Geschätzten Trächtigkeitsdauerunclassified

Sonographic diagnosis of pregnancy and determination of fetal number and gestational age in ewes

Schmid¹,

Schiess²,

Tustain³

et al. 2016

SAT

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The aim of the present study was to evaluate accuracy of transabdominal ultrasonography for pregnancy diagnosis, determination of fetal number and estimation of gestational age in ewes. A total of 1068 ewes from 8 different flocks (Swiss White Alpine n = 379, Swiss Black-Brown Mountain n = 189, Oxford-type n = 164, Ostfriesian n = 154, Texel n = 104, Lacaune x Osfriesian crossbred n = 78) was investigated using an Ovi-Scan™ ultrasound scanner with a 3.5 MHz 170° mechanical axial probe (BCF Technology Ltd., BelIshill, Great Britain). Scanning was performed transabdominally at the right inguinal region in ewes restrained in standing position. Sonographic findings were compared with lambing data recorded by the farmers. Included in the analysis were all ewes that, at the time of examination, were not pregnant and those that were pregnant between 26 and 110 days with a known lambing date and number of lambs born (n = 882). The sensitivity of pregnancy diagnosis was 97.8% and the specificity 97.6% (overall accuracy 97.8%, n = 853). Sensitivity and specificity for discrimination between single and multiple pregnancies was 95.8% and 90.5% (overall accuracy 93.9%, n = 752), respectively, when multiples were defined as positive. Discrimination between twins and triplets reached a sensitivity of 86.0% and a specificity of 99.5% (overall accuracy 98.0%, n = 458) when triplets were defined as positive. Considering a gestation period of 150 days, the mean deviation of the estimated to the effective day of gestation at examination was 5.6 ± 5.0 days (n = 781). The correlation between estimated and true gestational age was very high (r=0.936, P<0.0001). In conclusion, a highly accurate and efficient diagnosis of pregnancy with reliable estimation of fetal number and age is possible using an Ovi-Scan™ ultrasound scanner by an experienced examiner.

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Comparison of 6-day progestagen treatment with Chronogest® CR and Eazi-breed™ CIDR® G intravaginal inserts for estrus synchronization in cyclic ewes

Cited by 22 publications

References 23 publications

Efficacy of using previously used controlled internal drug release (CIDR) insert on the reproductive performance, hormone profiles and economic measures of sheep

Efficacy of using previously used controlled internal drug release (CIDR) insert on the reproductive performance, hormone profiles and economic measures of sheep

Clinical Use of Progesterone and Its Relation to Oxidative Stress in Ruminants

Sonographic diagnosis of pregnancy and determination of fetal number and gestational age in ewes

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