Comparison of 2 Risk Prediction Models Specific for COVID-19: The Brescia-COVID Respiratory Severity Scale Versus the Quick COVID-19 Severity Index

Ak, Rohat; Kurt, Erdem; Bahadırlı, Suphi

doi:10.1017/dmp.2021.141

Cited by 18 publications

(19 citation statements)

References 14 publications

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“…The Brescia-COVID respiratory severity scale is a clinical and radiological dynamic algorithm developed during the first wave of the pandemic in Italy [ 18 ] that requires periodic reassessment, with a frequency rate based on subjective clinical judgment. Its predictive power was later validated, demonstrating a good performance in predicting ICU admission [ 19 ] and mortality [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Risk of Seven-Day Worsening and Death: A New Clinically Derived COVID-19 Score

Cruciata

Volpicelli

Bari

et al. 2022

Viruses

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This monocentric, retrospective, two-stage observational study aimed to recognize the risk factors for a poor outcome in patients hospitalized with SARS-CoV-2 infection, and to develop and validate a risk score that identifies subjects at risk of worsening, death, or both. The data of patients with SARS-CoV-2 infection during the first wave of the pandemic were collected and analyzed as a derivation cohort. Variables with predictive properties were used to construct a prognostic score, which was tried out on a validation cohort enrolled during the second wave. The derivation cohort included 494 patients; the median age was 62 and the overall fatality rate was 22.3%. In a multivariable analysis, age, oxygen saturation, neutrophil-to-lymphocyte ratio, C-reactive protein and lactate dehydrogenase were independent predictors of death and composed the score. A cutoff value of 3 demonstrated a sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of 93.5%, 68.5%, 47.4% and 97.2% for death, and 84.9%, 84.5%, 79.6% and 87.9% for worsening, respectively. The validation cohort included 415 subjects. The score application showed a Se, Sp, PPV and NPV of 93.4%, 61.6%, 29.5% and 98.1% for death, and 81%, 76.3%, 72.1% and 84.1% for worsening, respectively. We propose a new clinical, easy and reliable score to predict the outcome in hospitalized SARS-CoV-2 patients.

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Section: Discussionmentioning

confidence: 99%

Risk of Seven-Day Worsening and Death: A New Clinically Derived COVID-19 Score

Cruciata

Volpicelli

Bari

et al. 2022

Viruses

View full text Add to dashboard Cite

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“…The novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused an epidemic described as coronavirus disease 2019 (COVID-19) 2 . The spectrum of COVID-19 ranges from possibly asymptomatic patients to acute respiratory distress syndrome, which leads to severe progressive pneumonia and death 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of C-reactive protein and C-reactive protein-to-albumin ratio in predicting mortality among geriatric coronavirus disease 2019 patients

Doğanay²,

Yı́lmaz

2022

Rev. Assoc. Med. Bras.

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OBJECTIVE:The aim of this study was to evaluate and compare C-reactive protein and C-reactive protein-to-albumin ratio performances in predicting mortality of geriatric patients who visited the emergency department. METHODS:The data of patients with COVID-19 and aged 65 years and above, who visited emergency department during the study period, were retrospectively analyzed. The data were obtained from an electronic-based hospital information system. The area under the receiver operating characteristic curve and the area under the curve were used to assess each cutoff value discriminatory for predicting mortality. RESULTS:The mean age of the population included in this study was 76 (71-82) years, while 52.7% were males. The sensitivity, specificity, and area under the curve values for C-reactive protein in terms of mortality were calculated as 71.01, 52.34, and 0.635%, respectively, while the sensitivity, specificity, and area under the curve values for C-reactive protein-to-albumin ratio were calculated as 75.74, 47.66, and 0.645%, respectively (p<0.001). In the pairwise comparison for the receiver operating characteristic curves of C-reactive protein and C-reactive protein-to-albumin ratio, no statistically significant difference was found.CONCLUSIONS: Geriatric patients are the "most vulnerable" patient group against the COVID-19. In this study, both C-reactive protein and C-reactive protein-to-albumin ratio were found to be successful in predicting mortality for geriatric COVID-19 patients.

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“…COVID-19 pneumonia can quickly lead to acute respiratory distress syndrome and other serious complications. Acute respiratory distress syndrome (ARDS) that is unresponsive to treatment can lead to multi-organ failure and death [3].…”

Section: Introductionmentioning

confidence: 99%

“…The clinical spectrum of COVID-19 can range from asymptomatic up to the most severe forms of disease: ARDS, acute heart injury, or acute kidney injury [3,4]. Up to 32% of all positive patients require admission to an intensive care unit (ICU) and death may occur among these patients [5,6].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of blood gas lactate levels among COVID-19 patients

Hökenek

2021

J CLIN MED KAZ

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This study aims to assess the relationship of the blood gas lactate values of the patients who have 2019 coronavirus disease at the time of admission to the emergency department, to the mortality status of these patients and the intensive care unit requirement.Methods: This retrospective, observational study was conducted with patients diagnosed with COVID-19 in the emergency department of a tertiary hospital. Once the inclusion and exclusion criteria were applied, 292 patients remained. These patients were divided into 2 groups based on their lactate levels (Lactate ≤ 2 mmol/L and Lactate > 2 mmol/L). Then we compared the groups according to their intensive care unit requirement and mortality status.Results: Of the 292 patients in this study, the mean age was 68.3±15.9, of which 158 were men and 134 were women. In 136 (46.6%) of the patients, hyperlactatemia (lactate >2) was identified, while in 156 (53.4%) patients, normal lactate levels (lactate ≤2) were seen. The most common comorbidities in the patients were hypertension, diabetes mellitus, and cardiovascular diseases. Intensive care unit requirements and mortality status of the patients in the study, when compared with lactate levels, the mortality and intensive care unit rates of the hyperlactatemia group were statistically higher. Conclusion:This study discovered that COVID-19 patients who were hyperlactatemic had higher intensive care unit requirement and mortality rates when compared to COVID-19 patients who were nonhyperlactatemic. A larger sample size is required for future prospective studies in order to sufficiently determine the lactate and mortality relationship in patients with COVID-19.

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Comparison of 2 Risk Prediction Models Specific for COVID-19: The Brescia-COVID Respiratory Severity Scale Versus the Quick COVID-19 Severity Index

Cited by 18 publications

References 14 publications

Risk of Seven-Day Worsening and Death: A New Clinically Derived COVID-19 Score

Risk of Seven-Day Worsening and Death: A New Clinically Derived COVID-19 Score

Comparison of C-reactive protein and C-reactive protein-to-albumin ratio in predicting mortality among geriatric coronavirus disease 2019 patients

Prognostic value of blood gas lactate levels among COVID-19 patients

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