Prognostic value of blood gas lactate levels among COVID-19 patients

Abstract

This study aims to assess the relationship of the blood gas lactate values of the patients who have 2019 coronavirus disease at the time of admission to the emergency department, to the mortality status of these patients and the intensive care unit requirement.Methods: This retrospective, observational study was conducted with patients diagnosed with COVID-19 in the emergency department of a tertiary hospital. Once the inclusion and exclusion criteria were applied, 292 patients remained. These patients were divided into 2 groups based on their lactate levels (Lactate ≤ 2 mmol/L and Lactate > 2 mmol/L). Then we compared the groups according to their intensive care unit requirement and mortality status.Results: Of the 292 patients in this study, the mean age was 68.3±15.9, of which 158 were men and 134 were women. In 136 (46.6%) of the patients, hyperlactatemia (lactate >2) was identified, while in 156 (53.4%) patients, normal lactate levels (lactate ≤2) were seen. The most common comorbidities in the patients were hypertension, diabetes mellitus, and cardiovascular diseases. Intensive care unit requirements and mortality status of the patients in the study, when compared with lactate levels, the mortality and intensive care unit rates of the hyperlactatemia group were statistically higher. Conclusion:This study discovered that COVID-19 patients who were hyperlactatemic had higher intensive care unit requirement and mortality rates when compared to COVID-19 patients who were nonhyperlactatemic. A larger sample size is required for future prospective studies in order to sufficiently determine the lactate and mortality relationship in patients with COVID-19.

Arterial lactate as a risk factor for death in respiratory failure related to coronavirus disease 2019: an observational study

“…[28][29][30] Limited data exist on the potential association of arterial or venous lactate levels with mortality in non-ICU COVID-19 patients. 31,32 In our study of non-ICU patients, hyperlactatemia at admission was independently associated with in-hospital death at 30 days. Moreover, increased lactate levels were associated with the severity of respiratory failure as defined according to different respiratory indexes.…”

“…[28][29][30] Nevertheless, the association between lactate levels and mortality in COVID-19 patients in the non-ICU setting has been explored in a few studies. 31,32 Prompt identification of COVID-19 patients likely to deteriorate by a simple test such as lactate assessment would be crucial for tailoring patient management.…”

Association between D-dimer and mortality in COVID-19 patients: a single center study from a Turkish hospital

“…In the literature, there are many research articles and case reports examining the relationship between COVID-19-related abnormal coagulation and laboratory parameters and prognosis [4][5][6][7]. According to www.journals.viamedica.pl one study, key features of the first 99 hospitalized patients in Wuhan included increased activated partial thromboplastin time (aPTT) in 6% of patients, increased prothrombin (PT) in 5%, elevated D-dimer and biomarkers of increased inflammation in 36%, and thrombocytopenia in 12% [1].…”