Comparison of 18F-FLT PET and 18F-FDG PET for preoperative staging in non-small cell lung cancer

Yamamoto, Yuka; Nishiyama, Yoshihiro; Kimura, Naruhide; Ishikawa, Shinya; Okuda, Masaya; Bandoh, Shuji; Kanaji, Nobuhiro; Asakura, Masato; Ohkawa, Motoomi

doi:10.1007/s00259-007-0613-0

Cited by 52 publications

(35 citation statements)

References 23 publications

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“…Like other cancers, uptake of 18 F-FLT in lung cancers is significantly lower than that of 18 F-FDG, with lower sensitivity, higher specificity, and higher positive predictive value (68,(70)(71)(72). However, the correlation with proliferation is partially shown in response to treatment.…”

Section: Lung Cancermentioning

confidence: 90%

PET Imaging of Proliferation with Pyrimidines

Tehrani

Shields

2013

J Nucl Med

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Section: Lung Cancermentioning

confidence: 90%

PET Imaging of Proliferation with Pyrimidines

Tehrani

Shields

2013

J Nucl Med

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“…Furthermore, it has been demonstrated that 18 F-FLT uptake is significantly better than 18 F-FDG uptake as a measure of tumor proliferation (2,3). 18 F-FLT PET has also been shown to be more specific than 18 F-FDG PET for cancer staging, with fewer falsepositive findings in inflammatory lesions (3)(4)(5). However, some false-positive findings have been reported for 18 Because of these limitations of 18 F-FLT PET for tumor staging, monitoring tumor response to therapy is perhaps the most promising clinical application of 18 F-FLT PET.…”

Section: Imaging Of Tumor Cell Proliferationmentioning

confidence: 99%

Monitoring Tumor Response to Therapy with ¹⁸F-FLT PET

Weber

2010

J Nucl Med

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“…In addition, its biodistribution and metabolic profile are not ideal [7]. Consequently, [ 18 [8,9], but results have not been consistent [2,10,11].…”

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confidence: 99%

Reproducibility of quantitative 18F-3′-deoxy-3′-fluorothymidine measurements using positron emission tomography

Langen

Klabbers

Lubberink

et al. 2008

Eur J Nucl Med Mol Imaging

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Purpose Positron emission tomography (PET) using 18 F-3′-deoxy-3′-fluorothymidine ([ 18 F]FLT) allows noninvasive monitoring of tumour proliferation. For serial imaging in individual patients, good reproducibility is essential. The purpose of the present study was to evaluate the reproducibility of quantitative [ 18 F]FLT measurements. Methods Nine patients with non-small-cell lung cancer (NSCLC) and six with head-and-neck cancer (HNC) underwent [ 18 F]FLT PET twice within 7 days prior to therapy. The maximum pixel value (SUV max ) and a threshold defined volume (SUV 41% ) were defined for all delineated lesions. The plasma to tumour transfer constant (K i ) was estimated using both Patlak graphical analysis and nonlinear regression (NLR). NLR was also used to estimate k 3 , which, at least in theory, selectively reflects thymidine kinase 1 activity. The level of agreement between test and retest values was assessed using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. Results All primary tumours and >90% of clinically suspected locoregional metastases could be delineated. In total, 24 lesions were defined. NLR-derived K i , Patlakderived K i , SUV 41% and SUV max showed excellent reproducibility with ICCs of 0.92, 0.95, 0.98 and 0.93, and SDs of 16%, 12%, 7% and 11%, respectively. Reproducibility was poor for k 3 with an ICC of 0.43 and SD of 38%. Conclusion Quantitative [ 18 F]FLT measurements are reproducible in both NSCLC and HNC patients. When monitoring response in individual patients, changes of more than 15% in SUV 41% , 20-25% in SUV max and Patlak-derived K i , and 32% in NLR3k-derived K i are likely to represent treatment effects.

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Comparison of 18F-FLT PET and 18F-FDG PET for preoperative staging in non-small cell lung cancer

Abstract: In NSCLC, FLT PET showed better (although not statistically significant) specificity, positive predictive value and accuracy for N staging on a per-patient basis than FDG PET. However, FDG PET was found to have higher sensitivity for depiction of primary tumor than FLT PET.

Cited by 52 publications

References 23 publications

PET Imaging of Proliferation with Pyrimidines

PET Imaging of Proliferation with Pyrimidines

Monitoring Tumor Response to Therapy with ¹⁸F-FLT PET

Reproducibility of quantitative 18F-3′-deoxy-3′-fluorothymidine measurements using positron emission tomography

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Comparison of 18F-FLT PET and 18F-FDG PET for preoperative staging in non-small cell lung cancer

Abstract: In NSCLC, FLT PET showed better (although not statistically significant) specificity, positive predictive value and accuracy for N staging on a per-patient basis than FDG PET. However, FDG PET was found to have higher sensitivity for depiction of primary tumor than FLT PET.

Cited by 52 publications

References 23 publications

PET Imaging of Proliferation with Pyrimidines

PET Imaging of Proliferation with Pyrimidines

Monitoring Tumor Response to Therapy with 18F-FLT PET

Reproducibility of quantitative 18F-3′-deoxy-3′-fluorothymidine measurements using positron emission tomography

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Monitoring Tumor Response to Therapy with ¹⁸F-FLT PET