Comparison of 18F-FDG PET/CT scan and 99mTc-MDP bone scintigraphy in detecting bone metastasis in head and neck tumors

Al-Bulushi, Naima K.; Abouzied, Moheieldin M

doi:10.1097/mnm.0000000000000479

Cited by 10 publications

(7 citation statements)

References 9 publications

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“…Therefore, when establishing a diagnosis using WBBS, it should be closely combined with the medical history of patients and with other imaging examinations, if necessary, such as CT and MRI. 1 , 13 The low diagnostic specificity of WBBS dictates that in clinical practice, when we encounter the manifestation of uncharacteristic bone metastases, such as single or few lesions, it is difficult to establish a clear qualitative diagnosis. Since many benign lesions present with the manifestation of highly concentrated radioactivity, benign lesions cannot be distinguished by differences in their characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, other imaging examinations are often used concurrently to verify the diagnosis. 1 In this prospective study, single-photon emission computed tomography (SPECT)/computed tomography (CT) was performed on 41 patients, who presented with a V-shaped sign revealed by whole-body bone scintigraphy (WBBS). This was a special feature in the backbone of the fifth lumbar vertebra.…”

Section: Introductionmentioning

confidence: 99%

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Degeneration in the Zygapophysial Joint of the Fifth Lumbar Vertebra: The V-Shaped Sign Revealed by Bone Scintigraphy

Xie¹,

Liu²,

Cheng³

et al. 2021

IJGM

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Objective The aim of the study was to explore the nature of a V-shaped sign in the backbone of the fifth lumbar vertebra revealed by whole-body bone scintigraphy (WBBS). Methods A local single-photon emission computed tomography (SPECT) scan plus a computed tomography (CT) scan were performed on 41 patients in our department who had a V-shaped sign in the backbone of the fifth lumbar vertebra detected by WBBS. Image fusion was conducted to understand the manifestations of the changes in the V-shaped sign in the CT images in WBBS and to determine the nature of the lesion. Results All 41 patients presented with degenerative changes observed in the bilateral posterior zygapophysial joint of the fifth lumbar vertebra in the CT imaging bone window, bone hyperplasia of the articular process, joint surface hardening, and a joint gap. The vacuum sign could also be seen in some of these patients. Conclusion The typical V-shaped sign in the posterior zygapophysial joint of the fifth lumbar vertebra revealed by WBBS suggests degenerative changes in the zygapophysial joint of the fifth lumbar vertebra.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Degeneration in the Zygapophysial Joint of the Fifth Lumbar Vertebra: The V-Shaped Sign Revealed by Bone Scintigraphy

Xie¹,

Liu²,

Cheng³

et al. 2021

IJGM

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“…The accurate diagnostic efficacy of PET/CT in BT staging (19) has been confirmed in the clinical study of BT. The advantages of PET/CT in the diagnosis of BT or other tumors were summarized by El-Galaly et al (20), through extensive clinical data induction and comparison with other detection methods (21,22). They considered that the advantages of PET/CT in the diagnosis of different stages of tumor were that it could locate the lesion more accurately, detect the smaller lesion, and distinguish the benign, malignant and different stages of BT, abdominal neuroendocrine tumor and ovarian cancer, hepatocellular carcinoma by PET/CT imaging.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic efficacy of PET/CT in bone tumors

Han

et al. 2019

Oncol Lett

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Clinical value of PET/CT (positron emission tomography/computed tomography) in the diagnosis of malignant bone tumors (BT) was investigated. Fifty-four patients with BT were first diagnosed by ordinary CT and then by PET/CT. The diagnostic efficacy outcomes and diagnosis of malignant BT by clinical stage of the two methods for BT were observed and recorded, and the diagnostic value of PET/CT in the diagnosis of BT was evaluated. There were 14 cases of benign BT patients, 15 cases of stage I, 10 cases of stage II and 15 cases of stage III in malignant BT patients. The diagnostic coincidence rate of PET/CT was 92.59% and the diagnostic coincidence rate of CT was 72.22%, which showed that the diagnostic coincidence rate of PET/CT was significantly higher than that of CT (P<0.05). The sensitivity, negative predictive value and positive predictive value of PET/CT were 95.00, 85.71 and 95.00%, respectively, which were higher than those of CT (P<0.05). CT and PET/CT were used for the clinical staging and pathological diagnosis of malignant BT; the results showed that the diagnostic accuracy of PET/CT in the clinical stages of malignant BT was also significantly higher than that of CT (P<0.05). The diagnostic efficacy of PET/CT in BT is better than that in CT. PET/CT can diagnose the pathological properties of BT more accurately, and can also effectively diagnose the clinical stage of malignant BT and provide clinical diagnostic basis for follow-up procedures.

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“…Radiolabeling of FeHA with 99m Tc was obtained by simply mixing 99m Tc-MDP solutions with a suspension of FeHA NPs. The chemical affinity of the MDP for HA due to the strong chemical binding of the bisphosphonate arm with the surface calcium sites of bone and synthetic HA is well reported [59,60]. In fact, bisphosphonates tagged radionuclides, including 99m Tc-MDP, are routinely used in bone scintigraphy applications for the diagnosis of bone metastasis, inflammation, fractures and infection, while radionuclide conjugated HA microparticles are used in clinics for therapeutic applications such as radiation synovectomy [60].…”

Section: Radiolabeling Of Fehamentioning

confidence: 99%

On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging

et al. 2018

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The ability of iron-doped hydroxyapatite nanoaprticles (FeHA) to work in vivo as imaging agents for magnetic resonance (MR) and nuclear imaging is demonstrated. FeHA applied an higher MR contrast in the liver, spleen and kidneys of mice with respect to Endorem®. The successful radiolabeling of FeHA allowed for scintigraphy/X-ray and ex vivo biodistribution studies, confirming MR results and envisioning FeHA application for dual-imaging.

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Comparison of 18F-FDG PET/CT scan and 99mTc-MDP bone scintigraphy in detecting bone metastasis in head and neck tumors

Abstract: F-FDG PET/CT is superior to Tc-methylene diphosphonate bone scan in detecting bone metastases in head and neck cancer.

Cited by 10 publications

References 9 publications

Degeneration in the Zygapophysial Joint of the Fifth Lumbar Vertebra: The V-Shaped Sign Revealed by Bone Scintigraphy

Degeneration in the Zygapophysial Joint of the Fifth Lumbar Vertebra: The V-Shaped Sign Revealed by Bone Scintigraphy

Diagnostic efficacy of PET/CT in bone tumors

On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging

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