Comparison of 18F-FDG PET/CT and MDCT for staging/restaging of non-small cell lung cancer

Šobić-Šaranović, Dragana; Petrušić, Igor; Artiko,; Pavlovic, S.; Subotic, Dragan; Šaranović, Dragana Šobić; Nagorni-Obradovic, Lj.; Petrović, Nikola; Todorović-Tirnanić, Mila; Odalović, Strahinja; Grozdic-Milojevic, I; Stoiljkovic, M; Obradović,

doi:10.4149/neo_2015_035

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…In recent decades, positron emission tomography (PET)/CT with fluorine-18-fludeoxyglucose ([ 18 F]FDG) has been extensively used in the preoperative setting for patients with lung cancer. This imaging approach is considered a key non-invasive staging method [ 16 ] and has shown better performance in LN staging (estimated sensitivity of 77% and specificity of 86%) compared to CT alone (55% and 81%, respectively) [ 17 , 18 , 19 ]. For PET imaging, the criterion for diagnosing LN involvement is the presence of LN uptake above the intensity of the surrounding background activity, with or without LN enlargement in co-registered CT imaging.…”

Section: Introductionmentioning

confidence: 99%

Additional Value of PET and CT Image-Based Features in the Detection of Occult Lymph Node Metastases in Lung Cancer: A Systematic Review of the Literature

et al. 2023

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Lung cancer represents the second most common malignancy worldwide and lymph node (LN) involvement serves as a crucial prognostic factor for tailoring treatment approaches. Invasive methods, such as mediastinoscopy and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), are employed for preoperative LN staging. Among the preoperative non-invasive diagnostic methods, computed tomography (CT) and, recently, positron emission tomography (PET)/CT with fluorine-18-fludeoxyglucose ([18F]FDG) are routinely recommended by several guidelines; however, they can both miss pathologically proven LN metastases, with an incidence up to 26% for patients staged with [18F]FDG PET/CT. These undetected metastases, known as occult LN metastases (OLMs), are usually cases of micro-metastasis or small LN metastasis (shortest radius below 10 mm). Hence, it is crucial to find novel approaches to increase their discovery rate. Radiomics is an emerging field that seeks to uncover and quantify the concealed information present in biomedical images by utilising machine or deep learning approaches. The extracted features can be integrated into predictive models, as numerous reports have emphasised their usefulness in the staging of lung cancer. However, there is a paucity of studies examining the detection of OLMs using quantitative features derived from images. Hence, the objective of this review was to investigate the potential application of PET- and/or CT-derived quantitative radiomic features for the identification of OLMs.

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Section: Introductionmentioning

confidence: 99%

Additional Value of PET and CT Image-Based Features in the Detection of Occult Lymph Node Metastases in Lung Cancer: A Systematic Review of the Literature

et al. 2023

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“…However, these methods have limited value in determining the nature of suspicious lung nodules, evaluating mediastinal involvement and also the tumor viability (4). Various radionuclide substances such as 67 Ga, 201Tl, and 99mTc-tetrofosmin, 99mTc-MIBI (technetium 99m hexakis 2-methoxy isobutyl isonitrile), and 18F-fluorodeoxyglucose are used in NSCLC staging, treatment response, and follow-up (4)(5)(6). The aim of this study is to evaluate the mediastinal lymph nodes (MLN) comparatively by using video-mediastinoscopy (VM), 99mTc-MIBI SPECT scintigraphy, and thoracic CT in the staging of NSCLC.…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Mediastinal Lymph Nodes in Non-small Cell Lung Cancer with Computed Tomography, 99mTc-MIBI SPECT, and Video-Mediastinoscopy

Önal¹,

Demir²

2017

Erciyes Med J

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Objective: The aim of this study is to evaluate the mediastinal lymph node (MLN) metastasis comparatively with Tc99m-MIBI SPECT scintigraphy, thoracic computed tomography (CT), and video-mediastinoscopy (VM) in the staging of non-small cell lung cancer (NSCLC). Materials and Methods:Forty consecutive patients (36 men, 4 women, average age 59.3 years) who were to undergo surgical treatment for NSCLC between June 2008 and June 2009 were included in this prospective study. All patients underwent chest 99mTc-MIBI SPECT before VM. SPECT results were evaluated visually and semi-quantitatively. Thoracotomy and MLN dissection were applied in patients who did not have MLN metastasis. Results:The MLN involvement was demonstrated in 6 patients via VM. 99mTc-MIBI SPECT correctly staged 5 out of 6 patients, and CT 2 out of 6 patients. The 99mTc-MIBI SPECT showed better results than CT with regard to positive and negative predictive values and accuracy.Conclusion: This study indicates that Tc99m-MIBI SPECT has a better diagnostic value than CT in detecting MLN metastases in NSCLC.Keywords: Lymph nodes, non-small cell lung cancer, technetium-99-m methoxy isobutyl isonitrile Erciyes Med J 2017; 39(4): 154-9 •

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FDG PET Hybrid Imaging

Becker¹,

Schwarzenböck²,

Krause³

2020

Recent Results in Cancer Research

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Comparison of 18F-FDG PET/CT and MDCT for staging/restaging of non-small cell lung cancer

Abstract: Non-small cell lung cancer, positron emission tomography, multidetector computed tomography, metastases detection.

Cited by 5 publications

References 19 publications

Additional Value of PET and CT Image-Based Features in the Detection of Occult Lymph Node Metastases in Lung Cancer: A Systematic Review of the Literature

Additional Value of PET and CT Image-Based Features in the Detection of Occult Lymph Node Metastases in Lung Cancer: A Systematic Review of the Literature

Comparative Evaluation of Mediastinal Lymph Nodes in Non-small Cell Lung Cancer with Computed Tomography, 99mTc-MIBI SPECT, and Video-Mediastinoscopy

FDG PET Hybrid Imaging

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