Comparison of 11C-Choline PET/CT and Enhanced CT in the Evaluation of Patients With Pulmonary Abnormalities and Locoregional Lymph Node Involvement in Lung Cancer

Peng, Zhongmin; Li, Renjie; Li, Meng; Han, Ming‐Yong; Yao, Shuzhan; Liu, Qi

doi:10.1016/j.cllc.2011.09.005

Cited by 18 publications

(9 citation statements)

References 15 publications

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“…Detecting lung cancer with 11 C-choline tracer has been reported in few studies (7,12,24,31). A high diagnostic accuracy of 11 C-choline PET/CT in lung cancer was reported with a sensitivity and a specificity of respectively 85.4% and 73.1 % by Peng et al (19). The detection rate of primary lung cancer was the same with 11 C-choline and 18 F-FDG in tumours larger than 2cm in diameter, but 18 F-FDG PET was superior to 11 C-choline in smaller lesions (12).…”

Section: Discussionmentioning

confidence: 98%

Significance of 18F-fluorocholine PET/CT positive pulmonary lesions in prostate cancer patients

Rager

Baskın²,

Amzalag³

et al. 2015

Nuklearmedizin

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Section: Discussionmentioning

confidence: 98%

Significance of 18F-fluorocholine PET/CT positive pulmonary lesions in prostate cancer patients

Rager

Baskın²,

Amzalag³

et al. 2015

Nuklearmedizin

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“…[ 12 , 15 ] Numerous case reports and clinical studies have also been published on 18 F-CH PET/CT positivity in other solid tumors. [ 13 , 22 ] In a recent paper by Sollini et al, [ 23 ] 7 patients with biochemical prostate cancer recurrence underwent 18 F-CH PET/CT and positive lesions were biopsied. Lung cancer was found in 5 patients, colorectal cancer in 1 patient, and lymph node metastases from melanoma in 1 patient.…”

Section: Discussionmentioning

confidence: 99%

“…Although radiolabeled choline (CH) PET/CT is widely accepted as a useful tool in prostate cancer staging, several human tumor-derived cell lines of different cancer histologies including breast, colon, prostate, lung, brain, and liver have shown an increased CH metabolism. [ 12 , 13 ] Some authors have also indicated the potential usefulness of 11 C- and 18 fluoro ( 18 F)-labeled CH PET/CT in bronchial NETs. No data are available on NETs of different origin.…”

Section: Introductionmentioning

confidence: 99%

Osteoblastic bone metastases from neuroendocrine tumor (NET) of unknown origin detected by 18fluorocholine PET/CT and its comparison with 68gallium-DOTATOC PET/CT

Bongiovanni

Recine

Celli³

et al. 2017

Medicine

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Rationale:Choline (CH) positron emission tomography (PET)/computed tomography (CT) with fluorine 18 (18F) CH is increasingly used not only to evaluate patients with biochemically recurrent prostate cancer but also to assess metastatic lesions that are difficult or impossible to identify using more conventional modalities. Our experience with CH PET/CT has shown that it can also be used for many other malignancies.Presenting concerns:A 71-year-old male with a neuroendocrine tumor (NET) of unknown origin showed osteoblastic bone metastases positive to 18F-CH PET.Interventions:Diffuse bone and liver metastases were 68gallium-DOTATOC PET-positive with only mild uptake on 18FDG PET/CT. An increased prostate specific antigen (8 μg/L) gave rise to a suspicion of concurrent prostate cancer and the patient underwent 18F-CH PET/CT which showed diffuse uptake in the bone. A CT-guided bone biopsy confirmed osteoblastic bone metastases from NET.Outcomes:Given the aggressiveness of the tumor, the patient underwent treatment with temozolomide from July 2015 to December 2015, maintaining stable disease. However, progression was documented in January 2016 and the patient was enrolled onto a phase II peptide receptor radionuclide therapy retreatment trial, which is currently ongoing.Main lesson:Our study highlights that NETs should be taken into consideration in the differential diagnosis of osteoblastic bone metastases showing 18F-CH uptake. A prognostic role for this imaging technique can also be hypothesized.

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“…Various other groups have also confirmed the value of choline PET imaging in the staging of lung cancer, especially with regards to assessment of mediastinal lymph node-and brain metastases [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…However, several authors have also evaluated its use in other malignancies [6][7][8]. Superiority of FEC PET over FDG PET has been demonstrated in differentiating low-grade glioblastomas from high-grade lesions, in detection of tumor recurrence and in guiding brain biopsies.…”

Section: Discussionmentioning

confidence: 99%

Imaging of Pulmonary Tuberculosis with 18F-Fluoro-Deoxy-Glucose and 18F-Ethylcholine

Vorster¹,

Stoltz²,

Jacobs³

et al. 2014

TONMEDJ

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Abstract:Introduction: A 37-year-old man was referred for PET/CT with the following diagnostic challenge: a longstanding smoking history, histologically confirmed TB and sarcoidosis with worsening chest-related symptoms and a non-responsive right upper lobe lung lesion (as detected on CT). Materials and Methods: PET/CT imaging was performed with18 F-FDG and followed by imaging with 18 F-fluoroethylcholine in an attempt to better characterize the lung lesion. This was followed by biopsies of the right upper lobe nodule, the pleura and a brain lesion.Results: Both tracers demonstrated increased uptake in the lung lesion and in multiple lymph node groups. Histology revealed the presence of a granulomatous disease in the lung lesion, the pleura and in the brain. Follow-up evaluation with 18 F-fluoroethyl-choline PET/CT demonstrated some improvement, which correlated with clinical improvement. Conclusion: Tuberculous lesions demonstrate increased accumulation of18 F-fluoroethyl-choline on PET/CT, which may be useful in the evaluation of treatment response. When used in combination with 18 F-FDG, it could be of value in distinguishing malignant lesions from tuberculosis.

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Comparison of 11C-Choline PET/CT and Enhanced CT in the Evaluation of Patients With Pulmonary Abnormalities and Locoregional Lymph Node Involvement in Lung Cancer

Cited by 18 publications

References 15 publications

Significance of 18F-fluorocholine PET/CT positive pulmonary lesions in prostate cancer patients

Significance of 18F-fluorocholine PET/CT positive pulmonary lesions in prostate cancer patients

Osteoblastic bone metastases from neuroendocrine tumor (NET) of unknown origin detected by 18fluorocholine PET/CT and its comparison with 68gallium-DOTATOC PET/CT

Imaging of Pulmonary Tuberculosis with 18F-Fluoro-Deoxy-Glucose and 18F-Ethylcholine

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