Significance of 18F-fluorocholine PET/CT positive pulmonary lesions in prostate cancer patients

AimTo prospectively evaluate the clinical impact and the diagnostic performance of FCH-PET/CT in patients with occult biochemical recurrence of prostate cancer (PCa).Materials and methodsResults of 179 patients (mean PSA = 7.5ng/mL) with negative/inconclusive results of pelvic-MRI and of bone-scintigraphy were analysed. To determine the impact of FCH-PET/CT on diagnostic thinking and on patient management, the referring physicians prospectively filled-in a 1st and 2nd questionnaire related to patient’s planned management before and after FCH-PET/CT. Based on data from a 6-month follow-up after FCH-PET/CT, an independent assessor blinded to results of FCH-PET/CT determined the adequacy of management changes motivated by FCH-PET/CT.ResultsFCH-PET/CT localised foci evocative of recurrent PCa in 59% (105/179) of patients. Results of FCH-PET/CT motivated a change in scheduled patient management in 56% (100/179) of patients; which was considered as adequate in 89% (89/100) of patients. FCH-PET/CT also led to the detection of lung cancer in two patients.ConclusionFCH PET/CT is a powerful tool to localise the sites of occult biochemical recurrence of PCa, leading to an adequate management change in half of patients.

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Lung uptake of fluorine-18 fluoroethyl-choline PET-CT in patients with prostate cancer

Pizzuto

Annunziata

Ieria

et al. 2019

Q J Nucl Med Mol Imaging

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Significance of 18F-fluorocholine PET/CT positive pulmonary lesions in prostate cancer patients

Abstract: Although our results suggest that incidental uptake in the lungs in PCa patients are nonspecific, their detection may have a significant impact on patient management knowing that more than 60% represent malignant disease.

Cited by 3 publications

References 30 publications

Imagerie du cancer de la prostate oligométastatique, le point de vue du médecin nucléaire

Imagerie du cancer de la prostate oligométastatique, le point de vue du médecin nucléaire

18F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study

Lung uptake of fluorine-18 fluoroethyl-choline PET-CT in patients with prostate cancer

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