Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne

Abstract

Background:Acne vulgaris is the most common skin disease. Local and systemic antimicrobial drugs are used for its treatment. But increasing resistance of Propionibacterium acnes to antibiotics has been reported.Materials and Methods:In a double-blind clinical trial, 40 patients with mild to moderate acne vulgaris were recruited. one side of the face was treated with Clindamycin Gel 1% and the other side with Azithromycin Topical Gel 2% BID for 8 weeks and then they were assessed.Results:Average age was 21. 8 ± 7 years. 82.5% of them were female. Average number of papules, pustules and comedones was similarly reduced in both groups and, no significant difference was observed between the two groups (P > 0.05, repeated measurs ANOVA). The mean indexes of ASI and TLC also significantly decreased during treatment in both groups, no significant difference was observed between the two groups. (P > 0.05, repeated measurs ANOVA). Also, impact of both drugs on papules and pustules was 2-3 times greater than the effect on comedones. Average satisfaction score was not significant between the two groups (P = 0.6, repeated measurs ANOVA). finally, frequency distribution of complications was not significant between the two groups (P > 0.05, Fisher Exact test).Conclusion:Azithromycin gel has medical impact at least similar to Clindamycin Gel in treatment of mild to moderate acne vulgaris, and it may be consider as suitable drug for resistant acne to conventional topical therapy.

The effectiveness of adapalene 0.1% with intense pulsed light versus benzoyl peroxide 5% with intense pulsed light in the treatment of acne vulgaris: A comparative study

“…[78] Topical therapies including antibiotics, benzoyl peroxide (BPO), retinoids, and sulfone agents are the first-line treatment in mild to moderate acne. [91011] The most common approach for treating AV is oral antibiotics plus topical retinoid or BPO. BPO is a non antibiotic, anti bacterial agent and lipophilic nature that reduce the sebaceous gland activity.…”

Efficacy of intense-pulsed light therapy with topical benzoyl peroxide 5% versus benzoyl peroxide 5% alone in mild-to-moderate acne vulgaris: A randomized controlled trial

“…[ 1 2 3 4 5 ] Even though various single and combinational treatments have been introduced, the best method is still controversial and this necessitates the search for less invasive, fast, more tolerable and efficient, and long-lasting options. [ 6 7 ] Topical antibacterial agents are preferred to systemic treatments and benzoyl peroxide (BP) has distinct advantages among these topical options. BP is a nonantibiotic antibacterial agent and its keratolytic property reduces the sebaceous glands activity.…”