Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats

Azlina, Mohd Fahami Nur; Qodriyah, Hj Mohd Saad; Chua, Kien Hui; Kamisah, Yusof

doi:10.3748/wjg.v23.i32.5887

Cited by 15 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The vascular endothelial growth factor is required to stimulate the formation of granulation tissue and the development of new microvessels. Thus, the decrease in the gastric VEGF in IND-treated rats in this study connotes a delay in the healing of the gastric ulcer induced by IND and this is in accordance with a previous report [51]. However, administration of MECD stem elevated the VEGF level in a dose-dependent manner, suggesting that MECD stem has angiogenic potential that stimulates vascularization resulting in healing of the gastric ulcer.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Mechanisms underlying the healing potentials of the methanol extract of Chasmanthera dependens stem on indomethacin-induced gastric ulcer

Tijani

Farombi

Olaleye

2021

Egyptian Journal of Basic and Applied Sciences

View full text Add to dashboard Cite

Chasmanthera dependens stem is used in African traditional medicine as a remedy for various maladies; however, scientific evidence to validate its uses in gastric ulcer healing is lacking. This study investigated the mechanisms underlying the healing potentials of the methanol extract of C. dependens stem (MECD) on the indomethacin-induced gastric ulcer. Forty male Wistar rats at 8 weeks old were used in this study and divided into five groups (n = 8). Group 1: control group, group 2: indomethacin alone (ulcerated untreated), group 3: ulcerated + 200 mg/kg MECD, group 4: ulcerated + 400 mg/kg MECD and group 5: ulcerated + 50 mg/kg cimetidine. Treatment with either MECD or cimetidine was once daily for 14 days after ulcer induction. Histological gastric injuries, antioxidant, inflammatory and apoptotic markers were evaluated. The results obtained revealed gastric mucosa damage as evident by marked histologic changes, increased ulcer score, ulcer index, lipid peroxidation, Tumor necrosis-alpha (TNF-α), Interleukin-1β (IL-1β), Cytochrome c (Cyt-c), Caspase-9 (Casp-9), Caspase-3 (Casp-3) and a number of apoptotic nuclei and significant decreased gastric antioxidant status, prostaglandin-E 2 (PGE 2) and vascular endothelia growth factor (VEGF) levels at p< 0.01. But MECD or cimetidine treatments significantly heal the ulcer and remarkably improved the biochemical parameters.

show abstract

Section: Discussionsupporting

confidence: 92%

“…Growth factors like VEGF regulate angiogenic wound healing at its different stages [50,51]. The vascular endothelial growth factor is required to stimulate the formation of granulation tissue and the development of new microvessels.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms underlying the healing potentials of the methanol extract of Chasmanthera dependens stem on indomethacin-induced gastric ulcer

Tijani

Farombi

Olaleye

2021

Egyptian Journal of Basic and Applied Sciences

View full text Add to dashboard Cite

show abstract

“…2018) and WIRS (Nur Azlina et al. 2017). It is well known that WIRS-induced gastric injury major on gastric mucosa, resulting in gastric mucosa erosion, oxidative stress and high inflammatory factors expression (Fu et al.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival

Sun

et al. 2019

Pharmaceutical Biology

View full text Add to dashboard Cite

2019) Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and prosurvival, Pharmaceutical Biology, 57:1, 770-777, ABSTRACTContext: Kangfuxin (KFX) is widely used for the treatment of gastric and duodenal ulcer; however, more research is needed to determine the protective mechanisms of KFX in ameliorating gastric ulcer. Objective: To investigate the efficacy and potential mechanism of Kangfuxin liquid (KFX) in water-immersion and restraint stress (WIRS)-induced gastric ulcer. Materials and methods: Seventy rats were randomly divided into seven groups (n ¼ 10) as follows: the control group (normal saline, i.g.), the model group (normal saline, i.g.), the KFX groups (2.5, 5 and 10 mL/kg, i.g.), the omeprazole group (20 mg/kg, i.p.) and Sanjiuweitai Granules group (1850 mg/kg, i.g.).The WIRS model was applied to induce stress ulcers after 7 days of drug administration. Afterwards, rats were sacrificed at 10 h induced by WIRS. Results: Pre-treatment with KFX (5,10 mL/kg) could effectively reduce the area of gastric ulcers and improve the pathological changes of ulcerated tissue. Moreover, KFX (5,10 mL/kg) increased the prostaglandin E2 (52%) and cyclooxygenase-1 (30%) levels, and improved malondialdehyde (54%), superoxide dismutase (58%), catalase (39%), and nitric oxide (11%) and TNF-a (9%), IL-6 (11%), MMP-9 (54%) and MMP-2 (53%) of ulcer tissue. Furthermore, pre-treatment with KFX dramatically increased IGF-1, PTEN, and Akt protein expression. Conclusions: Our results suggest that KFX has protective effects on WIRS-induced gastric ulcer via inflammatory reactions, oxidative stress inhibition, and pro-survival action, which were the results of activating the IGF-1/PTEN/Akt signalling pathway. Our results provide evidence of KFX for treating gastric ulcer. ARTICLE HISTORY

show abstract

“…This assists in maintenance and recovery of gastric tissue in the event of injury. T3 was reported to exert its effectiveness by diverse mechanisms of protection, including upregulating the expression of bFGF, TGF-α, and VEGF in a stress-induced gastric ulcer rat model [238], which ultimately prevents and repairs gastric mucosal injuries. A summary of the literature on the effects of T3 on stress-induced gastric ulcer model is shown in Table 11.…”

Section: Effects Of Tocotrienol On Peptic Ulcersmentioning

confidence: 99%

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

et al. 2020

Self Cite

View full text Add to dashboard Cite

Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties. This review aimed to summarize the health benefits of T3, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders, as well as cancers. Studies showed that T3 could prevent various NCDs, by suppressing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the mevalonate pathway, inflammatory response, oxidative stress, and alternating hormones. The efficacy of T3 in preventing/treating these NCDs is similar or greater compared to tocopherol (TF). TF may lower the efficacy of T3 because the efficacy of the combination of TF and T3 was lower than T3 alone in some studies. Data investigating the effects of T3 on osteoporosis, arthritis, and peptic ulcers in human are limited. The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials.Nutrients 2020, 12, 259 2 of 84 Nutrients 2020, 12, 259 4 of 84 the order δ > γ > β > α [45]. Using HepG2 cells, γT3 was shown to stimulate apolipoprotein B (Apo-B) degradation by decreasing its translocation into the endoplasmic reticulum (ER) lumen. This action eventually caused a reduction in the number of Apo-B in lipoprotein particles [46]. Other reports showed that γT3 and δT3 had the potential to reduce the hepatic TG synthesis and very-low-density lipoprotein (VLDL) secretion by suppressing expression of genes involved in lipid homeostasis, particularly the TG, cholesterol, and VLDL biosynthesis. Moreover, δT3 also promoted the efflux of LDL through LDL receptor expression [47]. A summary of the literature on effect of T3 supplementation on lipid profile of hypercholesterolemic model in vitro is shown in Table 1.Animal models of dyslipidemia have been used to investigate the effects of T3 on lipid profile. Several animals have been tested, including chicken, swine and rodents (rats, hamsters, guinea pigs). In chickens fed with a varying level of αTF and γT3, Qureshi et al. (1996) showed that αTF enhanced the inhibition of HMGCR by γT3. They further stipulated that the vitamin E mixture should contain 15-20% of αTF and approximately 60% of γT3 or δT3 for optimal anti-cholesterol effects [48]. In the subsequent study, demonstrated that combination of 50 ppm T3-rich fraction (TRF) and 50 ppm lovastatin was more effective in suppressing HMGCR activity compared to lovastatin alone in chickens. The combination also reduced serum TC and LDL-C, TG, Apo-B, thromboxane B 2 , and platelet factor 4 in contrast to individual treatment [49]. Using chicken supplemented with 50 ppm of δT3, Qureshi et al. (2011) further revealed that δT3 reduced TC and LDL-C besides suppressing the lipid elevating effects of dexamethasone and potentiated the TG-lowering effect of riboflavin [50]. Using genetically hypercholesterolemic swine, Qureshi et al. (1991) demonstrated the significant effect of TRF in lowering serum TC, LDL-C, Apo-B, thrombo...

show abstract

Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats

Cited by 15 publications

References 38 publications

Mechanisms underlying the healing potentials of the methanol extract of Chasmanthera dependens stem on indomethacin-induced gastric ulcer

Mechanisms underlying the healing potentials of the methanol extract of Chasmanthera dependens stem on indomethacin-induced gastric ulcer

Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

Contact Info

Product

Resources

About