Comparison between three different saliva substitutes in patients with hyposalivation

Škrinjar, Ivana; Boras, Vanja Vučičević; Bakale, Iva; Rogulj, Ana Andabak; Brailo, Vlaho; Juras, Danica Vidović; Alajbeg, Ivan; Vrdoljak, Danko Velimir

doi:10.1007/s00784-015-1405-8

Cited by 22 publications

(23 citation statements)

References 17 publications

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“…Regarding the country of origin of the 10 studies, three[131921] were conducted in Iran, two[1420] in Thailand, one study in each of the following: Italy,[16] Croatia,[17] Japan,[18] and Germany. [22] In one study, the trial site is not clearly mentioned.…”

Section: Resultsmentioning

confidence: 99%

“…Sample size calculation was carried out in four studies. [14171920] It was not required in one study as it was an exploratory study. [22]…”

Section: Resultsmentioning

confidence: 99%

“…In four studies, the reason of xerostomia was radiation induced,[13192021] whereas in four studies, it was drug induced. [141722] One study was conducted on patients with diabetes to determine the effect of diabetes on SF. [16] In one study, patients with neutropenia were included in the study.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of artificial salivary substitutes in treatment of xerostomia: A systematic review

Assery

2019

J Pharm Bioall Sci

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Aim: To provide an update on artificial saliva used to maintain the health of the oral cavity of patients with severe hyposalivation. Materials and Methods: A literature search was conducted in April 2018 in three electronic databases (The Cochrane Central Register of Controlled Trials [CENTRAL], PubMed, and Embase) by combining key words and terms related to the population and intervention of the topic. Results: The databases search resulted in 455 titles and abstracts. Of these, 21 were judged to meet inclusion criteria and full texts were read. Finally, 10 clinical trials were included for qualitative synthesis. Conclusion: Published evidence suggests that all the artificial saliva products tested in included studies reduced symptoms of xerostomia. These products should specifically be selected according to the patients’ concerns and needs. However, the included studies presented a wide range of products and suffered from high risk of bias. Therefore, long-term randomized controlled trials on effects of various products are required.

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Section: Resultsmentioning

confidence: 99%

“…Sample size calculation was carried out in four studies. [14171920] It was not required in one study as it was an exploratory study. [22]…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of artificial salivary substitutes in treatment of xerostomia: A systematic review

Assery

2019

J Pharm Bioall Sci

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“…An ideal saliva substitute attempts to replicate the inherent properties of natural saliva: pleasant taste, appropriate consistency, good lubrication, adequate duration of effect, convenient, economical, free from side effects, anti‐infective, anticariogenic, remineralizing, and inhibitor of microflora …”

Section: Introductionmentioning

confidence: 99%

“…An ideal saliva substitute attempts to replicate the inherent properties of natural saliva: 14 pleasant taste, appropriate consistency, good lubrication, adequate duration of effect, convenient, economical, free from side effects, anti-infective, anticariogenic, remineralizing, and inhibitor of microflora. 15,16 Oral substitutes are available in different delivery modes such as mouth rinses/washes, patches, sprays, gels, and toothpastes. These may contain a variety of compounds consisting of hydroxyethyl cellulose, polyglyceryl methacrylate, hydroxypropyl methylcellulose, glycerol, canola oil, olive oil, linseed, and varying amounts of salivary enzymes.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of saliva substitutes and stimulants in the treatment of dry mouth

See

Mohammadi

Han³

et al. 2019

Special Care in Dentistry

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Aims To evaluate the efficacy of saliva substitutes and stimulants compared to placebo in improving findings of dry mouth not caused by Sjӧgren's. Methods and Results Four databases were searched (PubMed, Web of Science, Cochrane Library, and EMBASE) through March 2018. Only randomized controlled trials (RCT) using placebo interventions with dry mouth patients were included. Outcomes included salivary flow and self‐reported patient improvement. The Cochrane Collaboration's tool for assessing risk of bias was used. A total of 348 references were reviewed, resulting in 7 RCTs with 257 dry mouth patients with 5 studies at high risk of bias, 1 unclear and 1 low risk being included. Topical spray of 1% malic acid increased unstimulated (Difference in Means [DM] = 0.096, 95% CI = 0.092‐0.100; P < 0.001) and stimulated (DM = 0.203, 95% CI = 0.106‐0.300; P < 0.001) salivary flow in 2 studies. Patients using 1% malic acid topical spray were 5.4 times more likely to report improvement compared to placebo (95% CI = 2.634‐11.091; P < 0.001) in 2 studies. No significant improvements were found with other products when compared to placebo. Conclusion Use of 1% malic acid topical spray seems to improve dry mouth compared to placebo. Quality of the evidence was low due to risk of bias and imprecision.

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Artificial oral fluid characterisation: Potential for use as a reference matrix in drug testing

Gavrilović

Musenga

Cowan

et al. 2020

Drug Testing and Analysis

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Quality assurance schemes for drug‐screening programmes require access to large quantities of biological matrices for reference or control samples. This presents problems when the availability of a matrix, such as oral fluid (OF) for screening or for confirmatory purposes, limits the collection of large volumes. In such cases, synthetic alternatives of OF may provide a solution. The preparation of an artificial (synthetic) oral fluid (AOF) was conducted by dissolving its components (salts, surfactant, antimicrobial agent and mucin) in water. We characterised the physical properties of AOF to determine its suitability as a matrix for quality assurance purposes. The evaluation of pH, specific gravity (SG), conductivity (mS cm−1), freezing point depression (°C), light‐scattering and kinematic viscosity (mm2 s−1) showed AOF to be a stable, reliable matrix. Synthetic OF was prepared using components (mucin, surfactants and so on) obtained from different suppliers and a comparison was performed. Our results suggest that AOF is a feasible matrix for the preparation of quality assurance samples for confirmatory or drug screening programmes.

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Comparison between three different saliva substitutes in patients with hyposalivation

Abstract: Although all tested agents showed beneficial effect in alleviating hyposalivation symptoms, it seems that Buccotherm® was superior to Xeros® and marshmallow root.

Cited by 22 publications

References 17 publications

Efficacy of artificial salivary substitutes in treatment of xerostomia: A systematic review

Efficacy of artificial salivary substitutes in treatment of xerostomia: A systematic review

Efficacy of saliva substitutes and stimulants in the treatment of dry mouth

Artificial oral fluid characterisation: Potential for use as a reference matrix in drug testing

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