Comparison between the use of saline and seawater for nasal obstruction in children under 2 years of age with acute upper respiratory infection

Köksal, Tülin; Cizmeci, Mehmet Nevzat; Bozkaya, Davut; Kanburoğlu, Mehmet Kenan; Şahin, Şanlıay; Tas, Tugba; Yüksel, Çiğdem Nüket; Tatlı, Mustafa Mansur

doi:10.3906/sag-1507-18

Cited by 18 publications

(36 citation statements)

References 21 publications

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“…A Cochrane review concludes that the evidence is very limited 12 . In a recent report, both NS and sea-water drops (thrice/day) reduced the severity of URTI symptoms in young children 13 .…”

Section: Introductionmentioning

confidence: 87%

A pilot, open labelled, randomised controlled trial of hypertonic saline nasal irrigation and gargling for the common cold

Ramalingam

Graham

Dove

et al. 2019

Sci Rep

131

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There are no antivirals to treat viral upper respiratory tract infection (URTI). Since numerous viruses cause URTI, antiviral therapy is impractical. As we have evidence of chloride-ion dependent innate antiviral response in epithelial cells, we conducted a pilot, non-blinded, randomised controlled trial of hypertonic saline nasal irrigation and gargling (HSNIG) vs standard care on healthy adults within 48 hours of URTI onset to assess recruitment (primary outcome). Acceptability, symptom duration and viral shedding were secondary outcomes. Participants maintained a symptom diary until well for two days or a maximum of 14 days and collected 5 sequential mid-turbinate swabs to measure viral shedding. The intervention arm prepared hypertonic saline and performed HSNIG. We recruited 68 participants (2.6 participants/week; November 2014-March 2015). A participant declined after randomisation. Another was on antibiotics and hence removed (Intervention:32, Control:34). Follow up data was available from 61 (Intervention:30, Control:31). 87% found HSNIG acceptable, 93% thought HSNIG made a difference to their symptoms. In the intervention arm, duration of illness was lower by 1.9 days (p = 0.01), over-the-counter medications (OTCM) use by 36% (p = 0.004), transmission within household contacts by 35% (p = 0.006) and viral shedding by ≥0.5 log10/day (p = 0.04). We hence need a larger trial to confirm our findings.

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Section: Introductionmentioning

confidence: 87%

A pilot, open labelled, randomised controlled trial of hypertonic saline nasal irrigation and gargling for the common cold

Ramalingam

Graham

Dove

et al. 2019

Sci Rep

131

View full text Add to dashboard Cite

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“…There was no significant difference in the seawater and saline group; however, the children who received these interventions had significant relief in nasal congestion, sleep, and nutrition in comparison to placebo. [ 12 ]…”

Section: Resultsmentioning

confidence: 99%

“…Nasal saline drops reduced nasal congestion, weakness, rhinorrhea, and sleep quality in children <2 years who developed URTI. [ 12 ] Similarly, Wang et al . [ 13 ] found nasal saline wash benefited children with acute sinusitis in symptoms as assessed by the Pediatric Rhinoconjunctivitis Quality of Life Questionnaires.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal wash in preventing and treating upper respiratory tract infections: Could it prevent COVID-19?

Singh

Sharma²,

Singh

et al. 2020

Lung India

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Rapid transmission of the severe acute respiratory syndrome coronavirus 2 has led to the novel coronavirus disease 2019 (COVID-19) pandemic. The current emphasis is on preventive strategies such as social distancing, face mask, and hand washing. The technique of nasopharyngeal wash to prevent the virus from inhabiting and replicating in the nasal and pharyngeal mucosa has been suggested to be useful in reducing symptoms, transmission, and viral shedding in cases of viral acute respiratory tract infections. In rapid systematic review, we found studies showing some improvement in prevention and treatment of upper respiratory tract infections. We postulate that hypertonic saline gargles and nasal wash may be useful in prevention and for care of patients with COVID-19. The present evidence emphasizes the need of randomized controlled trials to evaluate the role and mechanism of nasopharyngeal wash in COVID-19.

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“… 10 , 11 Nasal irrigation using normal saline (0.9%) and seawater spray (2.3%) were useful in preventing upper respiratory infections in children. 12 , 13 Saline water gargling and saline nasal irrigation at hypertonic concentrations (1.5-3%) showed protection against the common cold. 14 There is also evidence on the beneficial effect of saline irrigation in chronic inflammatory conditions like rhino-sinusitis 15 , 16 , which is characterized by the blockage of sinuses.…”

Section: Introductionmentioning

confidence: 97%

“…Disinfection of the irrigation vessel/pot is also vital because unclean vessels may enable lodging of particulate matter that may become a nidus for bacterial infection. However, these limitations are only speculative, and long-term studies have not shown the emergence of any such issues 10 , 11 , 12 , 13 , 14 . For some beginners, saline nasal irrigation may appear slightly difficult than gargling, but studies have shown this to be a well-tolerated approach 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Do saline water gargling and nasal irrigation confer protection against COVID-19?

Panta

Chatti

Andhavarapu³

2021

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Highlights Sodium chloride causes inhibition in the replication of a range of DNA and RNA viruses. Saline water gargling and nasal irrigation represent simple, economical, practically feasible, and globally implementable strategies with therapeutic and prophylactic value. Saline water gargling and nasal irrigation are examples of harmless interventions. Saline water gargling and nasal irrigation are suitable options for the current crisis.

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Comparison between the use of saline and seawater for nasal obstruction in children under 2 years of age with acute upper respiratory infection

Abstract: Relief was seen in nasal congestion, weakness, sleep quality, and nutrition with the use of both saline and seawater in children with the common cold. Seawater or saline drops may be added to standard treatment protocols.

Cited by 18 publications

References 21 publications

A pilot, open labelled, randomised controlled trial of hypertonic saline nasal irrigation and gargling for the common cold

A pilot, open labelled, randomised controlled trial of hypertonic saline nasal irrigation and gargling for the common cold

Nasopharyngeal wash in preventing and treating upper respiratory tract infections: Could it prevent COVID-19?

Do saline water gargling and nasal irrigation confer protection against COVID-19?

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