Comparison between the effect of glibenclamide and captopril on experimentally induced diabetic nephropathy in rats

Akbar, Daad H.; Hagras, Magda M.; Amin, Hanan A.; Khorshid, Omayma

doi:10.1177/1470320312460881

Cited by 17 publications

(8 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, in our study urine volume was significantly increased in diabetic rats compared to control rats. Glibenclamide treated diabetic rats showed a significant reduction in urine volume compared to diabetic control rats and the results of the present study are in agreement with the studies done earlier [37,38]. Dubey et al (2013) have shown that treatment of diabetic rats with oleanolic acid decreased blood glucose level and increased glomerular filtration rate [39].…”

Section: Discussionsupporting

confidence: 93%

Anti-Hyperglycemic Effect of Terminalia Catappa Fruit Extract in Streptozotocin-Induced Diabetic Rats

Behl¹,

Kotwani²

2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: To explore the anti-hyperglycemic effect of fruit extract of Terminalia catappa (Indian almond), a potential medicine from plant origin in a diabetic rat model.Methods: Streptozotocin-induced chronic diabetic rat model was utilized in the study. Three doses of test drug, hydro-alcoholic fruit extract of Terminalia catappa in 20 mg/kg, 30 mg/kg and 40 mg/kg and a standard anti-diabetic drug, glibenclamide (10 mg/kg) was used. The study had a total of nine groups with eight animals in each group. Drugs were given orally every day for 12 w. Blood glucose, body weight and urine volume were measured weekly, glycosylated hemoglobin (HbA1c) was estimated at 12th week in all groups. Data for all parameters were analyzed using one-way ANOVA repeated measures followed by Mann-Whitney test.Results: Hydro-alcoholic fruit extract of T. catappa significantly decreased blood glucose, urine volume and increased body weight in a dose-dependent manner in diabetic rats. At 12th week, blood glucose level in control, diabetic control, glibenclamide, T. catappa (40 mg/kg) group was 96.25±2.05 mg/dl, 599.75±0.25 mg/dl, 248.25±11.45 mg/dl, 115.00±3.78 mg/dl respectively. Effect of T. catappa in 30 mg/kg and 40 mg/kg dose was significantly more than glibenclamide. At 12th week, HbA1c level in control, diabetic control, glibenclamide, T. catappa (40 mg/kg) was 2.94±0.33 mmol/l, 4.94±0.49 mmol/l, 3.61±0.28 mmol/l, 3.21±0.27 mmol/l. Treatment with T. catappa 30 mg/kg, 40 mg/kg and glibenclamide brought back the level of HbA1c to normal levels. The addition of glibenclamide to T. catappa (40 mg/kg) did not produce any additional effect on blood glucose and HbA1c levels compared to the effect of T. catappa (40 mg/kg) in diabetic rats.Conclusion: Terminalia catappa fruit extract exhibited a significant anti-hyperglycemic effect in diabetic rats and has a great potential to be used in diabetes.

show abstract

Section: Discussionsupporting

confidence: 93%

Anti-Hyperglycemic Effect of Terminalia Catappa Fruit Extract in Streptozotocin-Induced Diabetic Rats

Behl¹,

Kotwani²

2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

show abstract

“…Different sites of action, specifically related to blood glucose lowering abilities, may explain these findings. Furthermore, other studies have reported a conflicting action between GLI and anti-RAS medications [27]. Williams et al [28] reported that chronic GLI therapy resulted in higher blood pressure following infusion of Ang-II in diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

In vivo Assessment of Combined Effects of Glibenclamide and Losartan in Diabetic Rats

et al. 2018

View full text Add to dashboard Cite

Objective: Diabetic complications involve multiple pathological pathways, including hyperglycemia-induced oxidative stress and inflammation. Combination therapy is usually employed to improve treatment outcomes and to lower potential adverse effects. In this study, we evaluated the effects of antidiabetic and antihypertensive agents, glibenclamide (GLI) and losartan (LT), on diabetes mellitus (DM)-associated metabolic changes in rats. Materials and Methods: Streptozotocin-induced diabetic animals were orally treated with GLI 5 mg/kg and/or LT 25 mg/kg for 4 weeks. Blood glucose, insulin, aspartate aminotransferase, alanine aminotransferase, urinary creatinine, and urea levels were measured. Serum, liver, and kidney values of inflammatory markers, such as interleukin-1β, tumor necrosis factor alpha, and interleukin-6 were assessed, along with lipid peroxidation products (e.g., thiobarbituric acid reactive substances), endogenous antioxidants (e.g., glutathione), as well as antioxidant enzyme activities (e.g., catalase, superoxide dismutase, and glutathione peroxidase). Finally, histological changes in liver and kidney tissues were evaluated. Results: DM markedly induced systemic, hepatic, and renal inflammation and lowered antioxidant defense mechanisms. Treatment of diabetic rats with either GLI or LT significantly improved liver and kidney functions and histological structure. Moreover, both medications reduced signs of oxidative stress and inflammation in blood, liver, and kidney samples. Combining GLI and LT showed similar protective potential against systemic, hepatic, and renal oxidative stress and inflammation. Conclusion: Adding LT to GLI therapy revealed prospective antioxidant and anti-inflammatory action, while no synergistic or additive effects were observed.

show abstract

“…However, kidney impairment may also be associated with its recognised risk factors such as hypertension, altered metabolism, alcoholism and smoking. A study has been reported that end-stage kidney disease was observed particularly in type 2 diabetic patients and requires dialysis for effective management of kidney function simultaneously with antidiabetic therapies [49] . Sometimes antidiabetic medicines cause rare side effects including renal failure, hepatic dysfunction or tissue ischemia [50] .…”

Section: ++mentioning

confidence: 99%

Hypoglycaemic Effect of Glibenclamide: A Critical Study on the Basis of Creatinine and Lipid Peroxidation Status of Streptozotocin-induced Diabetic Rat

Pandarekandy¹,

Sreejesh²,

Thampi³

et al. 2017

pharmaceutical-sciences

View full text Add to dashboard Cite

Seena, et al.: A Critical Study on Hypoglycaemic Effect of GlibenclamideThe present study is aimed to evaluate the hypoglycaemic effect of glibenclamide monotherapy on streptozotocin-induced diabetic rats and therapeutic impact of this agent on various organs by measuring the oxidative stress biomarker, lipid peroxidation and creatinine after a specific period of oral treatment. Eighteen male Wistar rats were taken of which twelve were randomly selected and diabetes was induced using streptozotocin (40 mg/kg) intraperitoneally, while 6 rats were vehicle injected. After inducing diabetes, the animals were grouped into healthy normal, diabetic control and diabetic test groups. The diabetic test rats were treated with glibenclamide (10 mg/kg) orally for 10 days continuously. On the 30th day of the experiment, all the animals were sacrificed and their blood and a portion of both the liver and pancreas were taken for biochemical analysis. The experimental parameters such as body weight, fasting blood glucose level, serum creatinine level and tissue lipid peroxidation status using malondialdehyde assay were investigated. All the results of the experimental data were analysed statistically using one-way analysis of variance using the SPSS 16. The current study reveals that glibenclamide treatment has a significant role in lowering the blood glucose but at the same time it increased the oxidative stress, which was reflected in the elevated malondialdehyde activity of both the hepatic and pancreatic tissues.

show abstract

Comparison between the effect of glibenclamide and captopril on experimentally induced diabetic nephropathy in rats

Cited by 17 publications

References 42 publications

Anti-Hyperglycemic Effect of Terminalia Catappa Fruit Extract in Streptozotocin-Induced Diabetic Rats

Anti-Hyperglycemic Effect of Terminalia Catappa Fruit Extract in Streptozotocin-Induced Diabetic Rats

In vivo Assessment of Combined Effects of Glibenclamide and Losartan in Diabetic Rats

Hypoglycaemic Effect of Glibenclamide: A Critical Study on the Basis of Creatinine and Lipid Peroxidation Status of Streptozotocin-induced Diabetic Rat

Contact Info

Product

Resources

About