Comparison between sentinel lymph node hybrid scintigraphy and blue dye technique in breast cancer patients: An institutional experience

Early Institutional Experience of Dual Tracer and Single-Photon Emission Computed-Tomography/Computed-Tomography Mapping for Sentinel Node Biopsy: A Report of Two Early-Stage Breast Cancer

“…7,15 SPECT/CT, however, may not be advised for all breast cancer patients due to additional cost and irradiation-although it is deemed safe for pregnant surgeons and patients. 5 Nonetheless, current evidence suggests that it is indicated whenever planar imaging is difficult to interpret, equivocal, or negative. 7 Newer tracers such as indocyanine green (ICG) have also been successfully developed for SLNM.…”

“…2,3 Combining blue dye with radioisotope was found to yield a superior IR and FNR compared to using either tracer alone. 1,4,5 Although no standard methodology exists, the dual tracer technique (DTT) is considered as the gold-standard in many guidelines. Recently, single-photon emission computed-tomography/computed-tomography (SPECT/CT) was also incorporated in the preoperative SLNM workflow.…”

Advanced diagnostic imaging of sentinel lymph node in early stage breast cancer

“…5 Regarding radioactivity, attention should be paid to the "hottest" SLN, and all nodes counted as 10% or more of the hottest node should be removed (the "10% rule"). 6 Krzhivitskii et al 7 believed that increased tracer uptake with/without LN expansion can be used as markers of tumor metastasis. Taking the histopathological results as a reference, the accuracy of mixed SPECT and CT imaging in diagnosing early stage breast cancer clinically negative LN patients with axillary LN metastasis can reach 99%.…”

“…If the afferent lymphatic vessels cannot be identified, the first LN that appears is defined as SLN 5 . Regarding radioactivity, attention should be paid to the “hottest” SLN, and all nodes counted as 10% or more of the hottest node should be removed (the “10% rule”) 6 . Krzhivitskii et al 7 believed that increased tracer uptake with/without LN expansion can be used as markers of tumor metastasis.…”