Comparison between MRI with spin-echo echo-planar diffusion-weighted sequence (DWI) and histology in the diagnosis of soft-tissue tumours

Abstract

In our experience, DWI with qualitative and quantitative analysis correlated well with histology.

Short-term follow-up MRI after unplanned resection of malignant soft-tissue tumours; quantitative measurements on dynamic contrast enhanced and diffusion-weighted MR images

“…ADC is an established marker of tumour cellularity (highly cellular regions have low ADC values), 24 and ADC mapping has been used to investigate the benignity and malignancy of lesions. 25 In the present study, the maximum and mean ADC values were found to be significantly associated with the presence of residual tumour (p , 0.05), although the presence or absence of a low signal region on ADC maps was also found to be significant. Many authors who have studied the ADC values of various benign and malignant tumours have concluded that the mean ADC values of benign soft-tissue tumours and malignant soft-tissue tumours overlap.…”

Musculoskeletal Tumors: How to Use Anatomic, Functional, and Metabolic MR Techniques

“…ADC mapping has been explored for the differentiation of benign from malignant lesions in the musculoskeletal system by exploiting potential differences in cellularity between benign and malignant abnormalities (47). In addition, after any event that has caused a change in the amount of water within a tissue, such as may be due to tumor growth, neovascularity, or tumor necrosis (19), changes in signal intensity on the DW images are naturally expected (Fig 2c, 2i).…”

Role of diffusion‐weighted magnetic resonance imaging in the evaluation of scalp dermatofibrosarcoma protuberans

“…They and others found apparent diffusion coefficient values of benign soft tissue masses and malignant soft tissue tumors not significantly different, making the differentiation between benign and malignant impossible . The use of T1‐ and T2‐weighted MRI has been compared with DWI in the diagnosis of soft tissue tumors …”