Comparison between freestanding and tooth-connected partially stabilized zirconia implants after two years’ function in monkeys: A clinical and histologic study

Akagawa, Yasumasa; Hosokawa, Ryuji; Sato, Yuuji; Kamayama, Kenji

doi:10.1016/s0022-3913(98)70031-9

Cited by 146 publications

(161 citation statements)

References 21 publications

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“…These characteristics may overcome the drawback of titanium (Ti) implants that have gray coloring and hyper responsiveness, and has made them a popular choice in the field of dentistry [1][2][3] . A number of animal experiments and case reports have demonstrated that TZP implants show a similar osseointegration capability to that of Ti implants, suggesting the suitability of TZP as an implant material 4,5) . Various surface parameters have been shown to influence osteoblast behavior on titanium implants, including surface topography and physicochemistry [6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Response of osteoblast-like cells to zirconia with different surface topography

et al. 2013

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The objective of this study was to clarify the effect of surface topography on osteoblast-like cell behavior on yttria stabilized tetragonal zirconia polycrystals (TZP). Mirror-polished; blasted with 50-or 150-µm alumina (SB50 and SB150); and SB150 acid-etched with hydrofluoric acid (SB150E) were prepared on TZP. Initial attachment, proliferation and differentiation of MC3T3-E1 were evaluated. The scanning electron microscopy and Sdr (developed interfacial area ratio) values indicated that both micro-and nano-topographies produced on the SB150E surfaces. Although no clear differences were observed in initial cell attachment among specimens, the proliferation rate and expression of ALP activity on the SB150E specimens was significantly higher than that on the other specimens. These results indicate that the creation of micro-and nano-topographies on TZP by surface treatment offers a promising method of enhancing the proliferation and differentiation of MC3T3-E1 cells.

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Section: Introductionmentioning

confidence: 99%

Response of osteoblast-like cells to zirconia with different surface topography

et al. 2013

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“…Moreover, it offers an advantage over titanium (Ti) in that there is no risk of discoloration or hypersensitive reaction [2][3][4] . The osseointegration capability and durability of TZP implants has been reported to be similar to that of Ti implants in a number of animal experiments, indicating its suitability as an implant material at the ultrastructural level [5][6][7][8] . Histomorphometrical analysis, however, revealed that bone implant contact was slightly better on Ti than on TZP surfaces 9) .…”

Section: Introductionmentioning

confidence: 81%

Influence of thin carbonate-containing apatite coating with molecular precursor method to zirconia on osteoblast-like cell response

et al. 2014

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The influence of a thin carbonate-containing hydroxyapatite (CA) coating to tetragonal zirconia polycrystal (TZP) on osteoblastlike cell response was investigated. TZP disks were subjected to blasting and acid etching. Thin CA coatings were deposited by the molecular precursor method (TZP-CA). Initial cell adhesion of mouse osteoblast-like cells MC3T3-E1 was enhanced, and marked progress of actin filaments was observed on TZP-CA compared to on TZP. After 3, 5 or 7 days, cell proliferation on TZP-CA was significantly higher than that on TZP. Alkaline phosphatase activity was slightly lower on TZP-CA than on TZP at 7 days, and no difference was observed at 14 or 21 days. At 28 days incubation, collagenous fibers with mineral precipitants accompanied by phosphorous and amino groups were observed. These results indicate that thin CA coating with molecular precursor method offers promise as a means of enhancing cell response, particularly initial adhesion and proliferation of MC3T3-E1 cells.

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“…Alternative radiopacifying agents with superior physicochemical and biological properties are currently under consideration. ZrO2 is among these candidate radiopacifiers, as it is biocompatible and is currently used in the reconstruction of skeletal and dental tissues [32][33][34] . Therefore, in this study, we investigated the biological effects of a ZrO2-containing fast-setting calcium-silicate cement with respect to biocompatibility and odontogenicity.…”

Section: Discussionmentioning

confidence: 99%

Odontogenic effects of a fast-setting calcium-silicate cement containing zirconium oxide

et al. 2015

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A fast-setting calcium-silicate cement (Endocem) was introduced in the field of dentistry for use in vital pulp therapy. Similar to mineral trioxide aggregate (MTA), it contains bismuth oxide to provide radiopacity. Recently, another product, EndocemZr, which contains zirconium oxide (ZrO2) as a radiopacifier, was developed by the same company. In this study, the biological/odontogenic effects of EndocemZr were investigated in human primary dental pulp cells (hpDPCs) in vitro and on capped rat teeth in vivo. The biocompatibility of EndocemZr was similar to that of ProRoot and Endocem on the basis of cell viability tests and cell morphological analysis. The mineralization nodule formation, expression of odontogenic-related markers, and reparative dentin formation of EndocemZr group was similar to those of other material groups. Our results suggest that EndocemZr has the potential to be used as an effective material for vital pulp therapy, similar to ProRoot and Endocem.

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Comparison between freestanding and tooth-connected partially stabilized zirconia implants after two years’ function in monkeys: A clinical and histologic study

Cited by 146 publications

References 21 publications

Response of osteoblast-like cells to zirconia with different surface topography

Response of osteoblast-like cells to zirconia with different surface topography

Influence of thin carbonate-containing apatite coating with molecular precursor method to zirconia on osteoblast-like cell response

Odontogenic effects of a fast-setting calcium-silicate cement containing zirconium oxide

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