Comparison between flare up and down regulation effects of luteinizing hormone‐releasing hormone agonists in an in vitro fertilization program

Frydman, R.; Belaisch-Allart, J.; Parneix, I; Forman, Robert G.; Hazout, A.; Testart, J

doi:10.1016/0020-7292(89)90782-0

Cited by 9 publications

(10 citation statements)

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“…High LH levels might lead to decreased ICSI outcomes (Homburg et al, 1988, Loumaye et al, 1989, Tarlatzis et al, 1995, however, despite the observation of an increased estradiol levels in the study group we observed no deleterious effect on clinical outcomes with our protocol. Our findings regarding similar implantation and pregnancy rates corroborate with previous findings (Frydman et al, 1988, Acharya et al, 1992. Nevertheless, a randomized prospective study demonstrated a trend towards better implantation and pregnancy rates in the long GnRHa protocol (Ravhon et al, 2000).…”

supporting

confidence: 91%

Pituitary suppression with a GnRHa short protocol in an alternate day schedule associated with rhCG microdoses

Rodrigues¹,

Setti²,

Braga³

et al. 2014

JBRA Assisted Reproduction

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Objective: To evaluate a comfortable short protocol with GnRH agonist (GnRHa) in alternate days, with a step down method of gonadotropins administration associated with hCG microdose for young patients undergoing intracytoplasmic sperm injection. Methods: This study evaluated 89 ICSI cycles performed in female patients aged <36 years. Patients were submitted to a short protocol with GnRHa schedule in the study group (n= 25) and to a long pituitary suppression protocol in the control group (n=64). Results: The total dose of rFSH administered as well as estradiol levels on the day of hCG trigger were significantly lower in the short protocol group. There were no significant differences between the groups regarding the fertilization, high-quality embryos, implantation, pregnancy and miscarriage rates. However, mean ovarian stimulation cost

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supporting

confidence: 91%

Pituitary suppression with a GnRHa short protocol in an alternate day schedule associated with rhCG microdoses

Rodrigues¹,

Setti²,

Braga³

et al. 2014

JBRA Assisted Reproduction

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“…Follicular growth was stimulated by human menopausal gonadotropin (hMG) in conjunction with a luteinizing hormone-releasing hormone (LHRH) agonist. Ovulation was induced with 10 000 IU of human chorionic gonadotropin (hCG) and the oocytes were harvested 36 h later using a transvaginal ultrasound procedure (Frydman et al, 1988). The cumulus cells were removed by treatment with 0.1 per cent hyaluronidase (Sigma) in B2 medium.…”

Section: Oocyte Preparationmentioning

confidence: 99%

Cytogenetic analysis of human oocytes after subzonal insemination

et al. 1993

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Subzonal insemination has been proposed to achieve fertilization in cases where standard in vitro fertilization has failed. We present the results of chromosome analysis of oocytes after subzonal insemination. Our data suggest that the main cause (76 per cent) of the absence of cleavage after subzonal insemination is the total absence of sperm nucleus evolution of the injected spermatozoa. Our results also suggest that spermatozoa chromatin development is normal after subzonal insemination. Aneuploidy does not seem to be increased in zygotes after subzonal insemination. However, polyploidy was often more important than predicted by the observation of pronuclei (PN). Pronucleus development might be asynchronous and can appear earlier or later than after standard IVF. The cytogenetic risk after subzonal insemination might therefore be triploidy (if a triploid egg is transferred, because only 2 PN were seen) rather than aneuploidy or structural abnormalities.

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“…In addition, the functions of the corpus luteum may be hampered by long‐term use of GnRHa because of abolition of pulsatile endogenous production of gonadotropins 5 or direct antiovarian effects 6 . With short protocols, ovarian stimulation is initiated by the simultaneous use of GnRHa and gonadotropins 7 . Many investigators have observed good results when using both long and short protocols; however, some have reported that a lower PR use achieved similiar results.…”

Section: Introductionmentioning

confidence: 99%

Low dose gonadotropin‐releasing hormone agonist treatments with early discontinuation for controlled ovarian hyperstimulation in an in vitro fertilization program

Lee¹,

Ikuta

et al. 2003

Reprod Medicine & Biology

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Aim:The purpose of the present study was to investigate the applicability of a protocol for controlled ovarian hyperstimulation (COH) featuring early discontinuation of low dose gonadotropin-releasing hormone agonist (GnRHa) for ovulation induction for in vitro fertilization (IVF).Methods: Four hundred and eighty-seven women undergoing 555 IVF cycles were recruited into the study. Controlled ovarian hyperstimulation was achieved by using either a short protocol of low dose GnRHa (for 5 days only; groups 1 and 2) or a modified long protocol with early discontinuation of GnRHa (groups 3 and 4). Groups 1 and 3 received urinary folliclestimulating hormone (FSH) and groups 2 and 4 received recombinant FSH. Oocyte retrieval was performed 34 to 36 h after human chorionic gonadotropin (hCG) injection, followed by embryo transfer 3 days later.Results: Luteinizing hormone (LH) levels on the hCG injection day were lower with the modified long protocol (groups 3 and 4) than with the short 5-day treatment (groups 1 and 2). There were higher LH levels in group 1 than in groups 2, 3 and 4, resulting in a worse fertilization rate and clinical pregnancy rate. There were no statistically significant differences between groups 2, 3 and 4 in the rates of fertilization, clinical pregnancy and delivery. A higher estradiol (E 2 ) level in group 3 than in groups 1, 2 and 4 resulted in a worse implantation rate. Conclusion:Early cessation of GnRHa may not induce a premature LH surge in controlled ovarian hyperstimulation, while a low dose also offers a useful alternative to a long protocol of IVF. Ovarian stimulation with recombinant folliclestimulating hormone (rFSH) is considered to be favorable in this low dose GnRHa treatment. (Reprod Med Biol 2003; 2: 25-30)

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Comparison between flare up and down regulation effects of luteinizing hormone‐releasing hormone agonists in an in vitro fertilization program

Cited by 9 publications

References 0 publications

Pituitary suppression with a GnRHa short protocol in an alternate day schedule associated with rhCG microdoses

Pituitary suppression with a GnRHa short protocol in an alternate day schedule associated with rhCG microdoses

Cytogenetic analysis of human oocytes after subzonal insemination

Low dose gonadotropin‐releasing hormone agonist treatments with early discontinuation for controlled ovarian hyperstimulation in an in vitro fertilization program

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