Comparison between elemental composition of human fingernails of healthy and opium-addicted subjects by laser-induced breakdown spectroscopy

Shadman, Soran; Bahreini, Maryam; Tavassoli, Seyed Hassan

doi:10.1364/ao.51.002004

Cited by 27 publications

(10 citation statements)

References 19 publications

(34 reference statements)

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“…Emissions of excited atoms, ions, and molecules in this plasma are recorded as a spectrum and analyzed for atomic identification of the sample. In recent years, this technique is mostly used for analysis of different tissues, including hard tissues such as hair, 11 nails [12][13][14][15][16][17][18] and teeth [19][20][21][22] and soft tissues such as blood, 23 cervical, 24 liver 25 and colorectal tissues. 26 What sets this method apart from other conventional methods is the convenience of sample preparation, higher speed of performance and no direct connection with samples especially contaminant materials.…”

Section: Introductionmentioning

confidence: 99%

Feasibility Study on Discrimination of Neo-plastic and Non-Neoplastic Gastric Tissues Using Spark Discharge Assisted Laser Induced Breakdown Spectroscopy

et al. 2018

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Introduction: The present work is a novel in vitro study that evaluated the possibility of diagnosing neoplastic from nonneoplastic gastric tissues using spark discharge assisted laser induced breakdown spectroscopy (SD-LIBS) method. Methods: In these experiments, the low energy laser pulses ablated a tiny amount of tissue surface leading to plasma formation. Then, a spark discharge was applied to plasma in order to intensify the plasma radiation. Light emission from plasma was recorded as spectra which were analyzed. Gastric tissues of 5 people were studied through this method. Results: The SD-LIBS technique had the potential to discriminate normal and cancerous tissues based on the significant differences in the intensities of some particular elements. The comparison of normalized calcium (Ca) and magnesium (Mg) peaks of neoplastic and nonneoplastic gastric tissues could be viewed as a practical measure for tissue discrimination since Ca and Mg peaks in spectra of neoplastic were noticeably higher than nonneoplastic. Conclusion: Considering the identification of gastric cancer, the applied method in these experiments seems quite fast, noninvasive and cost-effective with respect to other conventional methods. The significant increment of specific Ca and Mg lines of neoplastic gastric tissues in comparison to the nonneoplastic ones can be considered as valuable information that might bring about tissue classification. The number of samples in this work, however, was not sufficient for a decisive conclusion and further researches is needed to generalize this idea.

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Section: Introductionmentioning

confidence: 99%

Feasibility Study on Discrimination of Neo-plastic and Non-Neoplastic Gastric Tissues Using Spark Discharge Assisted Laser Induced Breakdown Spectroscopy

et al. 2018

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“…Such advantages make LIBS a potentially powerful technique for detection and analysis of organic materials including PAHs [2,3], nitro compounds [4,5], polymers [6][7][8][9][10], explosives [11][12][13][14][15] and biological samples [16][17][18]. However, as compared to traditional applications of LIBS for metallic alloys, its routine use for analysis of organic materials still remains a challenge.…”

Section: Introductionmentioning

confidence: 99%

CN and C2 vibrational spectra analysis in molecular LIBS of organic materials

et al. 2016

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“…In some previous works, for example in investigating the correlation between disease and fingernail elements [25][26][27], we could not be sure whether the differences between the fingernail element spectra are due to the disease or the experimental fluctuations. Consequently, we improved the repeatability of spectra as the most important affecting factor, by designing and applying a point auto-focus system.…”

Section: Geometrical and Applied Opticsmentioning

confidence: 99%

Repeatability improvement of laser-induced breakdown spectroscopy using an auto-focus system

2015

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Laser-induced breakdown spectroscopy (LIBS) is a novel technique for elemental analysis of materials. The repeatability of LIBS results is an important issue in many applications. Many factors influence the repeatability of LIBS results. The aim of this study is to examine the effect of laser beam focusing position or lens to sample distance (LTSD) as one of the most important factors influencing LIBS spectra. A point auto-focus system is designed and applied to provide the same lens to sample distance in every LIBS experiment. This system is employed and the result is compared to that of non-auto-focus technique on samples with different degrees of evenness such as aluminum, paper, tape and human fingernail. The standard deviation of this experiment is measured in the range of 4 to 26 μm. Then, spectrum's repeatability is examined with two samples of aluminum and human fingernail. The standard deviation of spectra is considerably reduced. In conclusion, repeatability of LIBS results could be optimized by using the auto-focus system.

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Comparison between elemental composition of human fingernails of healthy and opium-addicted subjects by laser-induced breakdown spectroscopy

Cited by 27 publications

References 19 publications

Feasibility Study on Discrimination of Neo-plastic and Non-Neoplastic Gastric Tissues Using Spark Discharge Assisted Laser Induced Breakdown Spectroscopy

Feasibility Study on Discrimination of Neo-plastic and Non-Neoplastic Gastric Tissues Using Spark Discharge Assisted Laser Induced Breakdown Spectroscopy

CN and C2 vibrational spectra analysis in molecular LIBS of organic materials

Repeatability improvement of laser-induced breakdown spectroscopy using an auto-focus system

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