Comparison between electrocoagulation and solvent extraction method in the process of the dechlorophyllation of alcoholic extracts from Moroccan medicinal plants Petroselinum crispum, Thymus satureioides and microalgae Spirulina platensis

Kouar, Jihane; Lamsaddek, Azzeddine; Benchekroun, Rajae; Elamrani, Abdelaziz; Cherif, Abdelmjid; Bellahcen, Touria Ould; Kamil, Noureddine

doi:10.1007/s42452-018-0137-1

Cited by 10 publications

(6 citation statements)

References 36 publications

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“…Here, we showed that the extract contains a high content of total phenolics and flavonoids and exhibits a strong antioxidant potential using both DPPH and ABTS assays. Similar observations were reported showing that T. satureioides extracts were the richest in total phenolics (up to 70.2 mg GAE/g) and flavonoids (up to 52.7 mg QuE/g) compared to the other extracts from Petroselinum crispum and the microalgae Spirulina platensis [26]. Elsewhere, the aqueous extract of T. satureioides was also shown to elicit ferric-reducing antioxidant power (FRAP) at up to 7.03 ± 0.29 mmol trolox/g [27].…”

Section: Discussionsupporting

confidence: 89%

Thymus satureioides Coss.: Mineral Composition, Nutritional Value, Phytochemical Profiling, and Dermatological Properties

et al. 2023

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Zaitra, Thymus satureioides, is an aromatic plant with a long history of use in traditional medicine. In this study, we assessed the mineral composition, nutritional value, phytocontents, and dermatological properties of the aerial parts of T. satureioides. The plant contained high contents of calcium and iron, moderate levels of magnesium, manganese, and zinc, and low contents of total nitrogen, total phosphorus, total potassium, and copper. It is rich in several amino acids, including asparagine, 4-hydroxyproline, isoleucine, and leucine, and the essential amino acids account for 60.8%. The extract contains considerable amounts of polyphenols and flavonoids (TPC = 118.17 mg GAE/g extract and TFC = 32.32 mg quercetin/g extract). It also comprises 46 secondary metabolites, identified through LC-MS/MS analysis, belonging to phenolic acids, chalcones, and flavonoids. The extract elicited pronounced antioxidant activities, inhibited the growth of P. aeruginosa (MIC = 50 mg/mL), and reduced biofilm formation by up to 35.13% using the ¼ sub-MIC of 12.5 mg/mL. Moreover, bacterial extracellular proteins and exopolysaccharides were diminished by 46.15% and 69.04%, respectively. Likewise, the swimming of the bacterium was impaired (56.94% decrease) in the presence of the extract. In silico, skin permeability and sensitization effects revealed that out of the 46 identified compounds, 33 were predicted to be exempt from any skin sensitivity risk (Human Sensitizer Score ≤ 0.5), while extensive skin permeabilities were observed (Log Kp = −3.35–−11.98 cm/s). This study provides scientific evidence about the pronounced activities of T. satureioides, supports its traditional uses, and promotes its utilization in the development of new drugs, food supplements, and dermatological agents.

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Section: Discussionsupporting

confidence: 89%

Thymus satureioides Coss.: Mineral Composition, Nutritional Value, Phytochemical Profiling, and Dermatological Properties

et al. 2023

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“…5). This finding is in agreement with the results of works [31][32][33][34] on the extracts who indicate that the solvent mixture water/alcohol would better extract phenolic compounds than alcohol alone. The use of ethanol/water mixture (67/33 v/v) in this study could justify thus a high solubility of the phenolic compounds.…”

Section: Total Tannins Content (Ttc)supporting

confidence: 93%

Removal of chlorophyll and tannins from Anthocleista schweinfurthii Gilg leaves by electrocoagulation using iron electrodes: optimization using response surface methodology

Tsopjio

Tchamango

Momeni

et al. 2020

J of Chemical Tech & Biotech

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BACKGROUND An electrocoagulation process using iron electrodes was applied for chlorophyll and tannins removal from ethanol extract of aerial parts of Anthocleista schweinfurthii Gilg. A second‐order regression using Central Composite Design (CCD) was used to investigate the main effects of four independent variables, namely supporting electrolyte concentration (in g L−1), ethanol percentage (%), current intensity (in amps) and electrolysis time (in minutes) and their interactions. The chlorophyll removal (CR), total tannins content (TTC) and total phenols content (TPC) were analyzed using response surface methodology (RSM) and CCD. Crude and optimized extracts were characterized by UV‐visible spectrometry and Fourier‐transform infrared spectroscopy. RESULTS The RSM model obtained from the present study (R2 > 0.95) showed a good fit which suggests a good correlation between the predicted values and experimental results of CR and tannins removal. Under optimized conditions (supporting electrolyte concentration 2.4 g L−1; ethanol percentage 67%; current intensity 0.4 A and electrolysis time 75 min), CR of 98.23% and TTC of 58.83% were achieved while remaining 91.21% of TPC. CONCLUSION Ethanol percentage, current intensity and electrolysis time influences positively CR, TTC and TPC. According to the results, electrocoagulation is an appropriate technique indicated for extracting secondary metabolites while reducing the risks associated with the use of organic solvents. © 2020 Society of Chemical Industry

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“…Interestingly, Kouar et al [ 38 ] have determined the phytochemical profile of alcoholic extract of T. satureioides leaves, using the electrocoagulation and solvent extraction assays, and detected the presence of saponins, sterols, triterpene, tannins, and flavone aglycones. The quantitative analysis showed that T. satureioides alcoholic extract contains high levels of total polyphenols (70.2 ± 0.4 mg of gallic acid equivalents/g extract) and total flavonoids (52.7 ± 0.01 mg of quercetin equivalents/g extract).…”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss.

Chebat

Fikri-Benbrahim

2021

Evidence-Based Complementary and Alternative Medicine

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Thymus satureioides Coss. (Lamiaceae) is a Moroccan medicinal plant locally known as “Azkouni” or “Zaitra.” It is widely used in traditional medicine to treat various ailments, including hypertension, diabetes, cold, fever, dermatological and circulatory disorders, immune problems, bronchitis, nociception, cooling, pharyngitis, cough, and influenza. The current review aims to critically summarize the literature on ethnopharmacological uses, chemical profile, and pharmacological investigations of T. satureioides in order to provide data support and scientific evidences for further investigations. Electronic databases such as Scopus, PubMed, Web of Science, SciFinder, ScienceDirect, Google Scholar, and Medline were used to gather data on T. satureioides. Chemical characterization of T. satureioides essential oils (EOs) and extracts allowed to identify a total of 139 bioactive compounds, mainly belonging to the terpenoids, phenolic acids, and flavonoids classes. T. satureioides especially its essential oils exhibited numerous biological activities such as antibacterial, antifungal, anti-inflammatory, antioxidant, antidiabetic, anticancer, antiparasitic, and hypolipedemic activities. In light of these findings, further studies to transmute the traditional application of T. satureioides into scientific-based information are strongly required. Additional in vivo pharmacological studies are recommended to validate the results of the in vitro studies. Moreover, comprehensive preclinical and clinical trials on the pharmacological mechanisms of action of this plant and its bioactive compounds on molecular targets should be performed. Finally, more efforts must be focused on toxicological assessments and pharmacokinetic studies, in order to ensure the safety and the efficiency of T. satureioides.

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Comparison between electrocoagulation and solvent extraction method in the process of the dechlorophyllation of alcoholic extracts from Moroccan medicinal plants Petroselinum crispum, Thymus satureioides and microalgae Spirulina platensis

Cited by 10 publications

References 36 publications

Thymus satureioides Coss.: Mineral Composition, Nutritional Value, Phytochemical Profiling, and Dermatological Properties

Thymus satureioides Coss.: Mineral Composition, Nutritional Value, Phytochemical Profiling, and Dermatological Properties

Removal of chlorophyll and tannins from Anthocleista schweinfurthii Gilg leaves by electrocoagulation using iron electrodes: optimization using response surface methodology

Ethnopharmacology, Phytochemistry, and Pharmacological Properties of Thymus satureioides Coss.

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