Comparing Three Post-Op Regiments for Management of Inflammation Post Uncomplicated Cataract Surgery. “Are Steroids Really Necessary?”

Duong, Hon-Vu Q.; Westfield, Kenneth C.; Singleton, Isaac C.

doi:10.4172/2155-9570.1000163

Cited by 12 publications

(13 citation statements)

References 28 publications

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“…22,25 Specific to this study, the IOPs were not measured because our previous study 22 demonstrated a rise in IOP associated with the use of topical steroid. Studies have shown the risks associated with topical steroids, and recent studies demonstrate that a topical steroid is not necessary in controlling inflammation after cataract surgery.…”

Section: Discussionmentioning

confidence: 99%

“…22,25 The authors believe that the pharmacological approach should be tailored to each patient undergoing cataract surgery, based on the patient's ocular and medical history, as opposed to mass ''standardized'' treatments for all patients. 22,25 The authors believe that the pharmacological approach should be tailored to each patient undergoing cataract surgery, based on the patient's ocular and medical history, as opposed to mass ''standardized'' treatments for all patients.…”

Section: Discussionmentioning

confidence: 99%

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Treatment Paradigm After Uncomplicated Cataract Surgery

Duong

Westfield²,

Singleton³

2014

Asia-Pacific Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Treatment Paradigm After Uncomplicated Cataract Surgery

Duong

Westfield²,

Singleton³

2014

Asia-Pacific Journal of Ophthalmology

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“…Corticosteroids are notorious for increasing IOP, something that is completely avoided with the use of NSAIDs alone. Duong et al recently conducted a post-operative inflammation study, 14 where they looked at three groups: a bromfenac-alone group, bromfenac plus steroid and a steroid-alone group. The only group which did not show a post-operative pressure spike was the NSAID-only group.…”

Section: Discussionmentioning

confidence: 99%

Management of Ocular Inflammation following Routine Cataract Surgery— Topical Corticosteroid (Prednisolone) versus Topical Non-steroidal (Bromfenac)

Walter¹,

Estes²,

Watson³

et al. 2011

US Ophthalmic Review

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Purpose:To determine whether bromfenac as a single agent is just as safe and effective as a corticosteroid in post-operative cataract surgery.Methods:Retrospective chart review compared over 400 eyes undergoing cataract surgery. Two hundred eyes were analyzed in each group. The first group received topical Pred Forte® 1 % (prednisolone acetate 1 %, Allergan) four times daily for two weeks, then tapered over the following three weeks, and the second group had topical Bromday™ (bromfenac 0.09 %, ISTA) as a single agent once daily, two days before surgery and for four weeks after. Outcomes measured were best corrected visual acuity (BCVA), post-operative pain, inflammation, cystoid macular edema (CME), and raised intraocular pressure (IOP).Results:Both groups had excellent vision improvement, to 20/27.2 (Pred Forte group) and 20/26.6 (Bromday group) average BCVA at one month post-operation. Both groups had excellent pain and inflammatory control at the one-day, two-week, and one-month time points. There were two eyes (1 %) in the steroid group with CME and only one eye (0.5 %) in the Bromday group. Most remarkably, when looking at one week post-operation or later, there were 16 eyes (8 %) in the corticosteroid group with an elevation in IOP greater than 5 mmHg above baseline, and only five eyes (2.5 %) in the Bromday group (p=0.02) had IOP elevation not attributable to another cause. When considering those eyes with a history of glaucoma, eight out of 25 (32 %) in the corticosteroid group had an elevated IOP in the first week or later, whereas there were no eyes out of 17 (0 %) in the Bromday group.Conclusions:Bromfenac is a safe and effective non-steroidal anti-inflammatory drug (NSAID) when used in the post-operative management of cataract surgery. It appears to be as effective as a topical steroid, even when used alone, without the risk of elevated IOP.

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“…7 The post-operative treatment of cataract include three topical pharmaceutical agents: an antimicrobial, a potent corticosteroid and a non-steroidal antiinflammatory drug (NSAID). 8…”

Section: Cataractmentioning

confidence: 99%

Ophthalmic Drug Delivery System-A Concise Review on its Conventional and Novel Approaches

Arora

Singh

Chaurasia

2019

Curr. Res. Pharm. Sci.

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The main aim of this review is to focus on the various kinds of approaches which are used in ophthalmic drug delivery. Ophthalmic drug delivery system is used to treat various conditions associated with eye. The main purpose of a formulation designer is to formulate an eye formulation which could reside in the eye in an optimum concentration and for a proper duration for its proper effect. The main problem seen in the conventional dosage forms is their poor bioavailability due to fast precorneal drug loss primarily due to nasolacrimal drainage. The residence time of conventional formulations is also very less in the eye resulting into minimal advantages. In order to combat all these problems, now days the pharmaceutical scientists are very much involved in the research towards the novel approaches of ophthalmic drug delivery. The present paper enlists the important novel formulations which have been developed recently and explore their various advantages over conventional forms.

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Comparing Three Post-Op Regiments for Management of Inflammation Post Uncomplicated Cataract Surgery. “Are Steroids Really Necessary?”

Cited by 12 publications

References 28 publications

Treatment Paradigm After Uncomplicated Cataract Surgery

Treatment Paradigm After Uncomplicated Cataract Surgery

Management of Ocular Inflammation following Routine Cataract Surgery— Topical Corticosteroid (Prednisolone) versus Topical Non-steroidal (Bromfenac)

Ophthalmic Drug Delivery System-A Concise Review on its Conventional and Novel Approaches

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