Comparing the effects of meal replacements with an isocaloric reduced‐fat diet on nutrient intake and lower urinary tract symptoms in obese men

Khoo, Joan; Ling, P.‐S.; Chen, R. Y.‐T.; Ng, Kok Kit; Tay, T.; Tan, Eng Loy; Cho, L.‐W.; Cheong, Magdalin

doi:10.1111/jhn.12151

Cited by 9 publications

(20 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings are in contrast to prior reports [6,7,35,36] where improvements in the SDI or IPSS occurred following weight losses of 2-6-12.3 kg over 8–52 weeks. We note that an improvement in the storage LUTS score occurred for those with the presence of features of lower urinary tract symptoms relating to storage symptoms at baseline.…”

Section: Discussioncontrasting

confidence: 99%

Long-Term Effects of a Randomised Controlled Trial Comparing High Protein or High Carbohydrate Weight Loss Diets on Testosterone, SHBG, Erectile and Urinary Function in Overweight and Obese Men

et al. 2016

View full text Add to dashboard Cite

IntroductionObesity is associated with reduced testosterone and worsened erectile and sexual function in men. Weight loss improves these outcomes. High protein diets potentially offer anthropometric and metabolic benefits, but their effects on reproductive and sexual outcomes is not known.AimTo examine the long-term effects of weight loss with a higher protein or carbohydrate diet on testosterone, sex hormone binding globulin, erectile dysfunction, lower urinary tract symptoms and sexual desire in overweight and obese men.MethodsOne-hundred and eighteen overweight or obese men (body mass index 27–40 kg/m2, age 20–65 years) were randomly assigned to an energy restricted higher protein low fat (35% protein, 40% carbohydrate, 25% fat; n = 57) or higher carbohydrate low fat diet (17% protein, 58% carbohydrate, 25% fat, n = 61) diet for 52 weeks (12 weeks weight loss, 40 weeks weight maintenance). Primary outcomes were serum total testosterone, sex hormone binding globulin and calculated free testosterone. Secondary outcomes were erectile function as assessed by the International Index of Erectile Function (IIEF) (total score and erectile function domain), lower urinary tract symptoms and sexual desire.ResultsTotal testosterone, sex hormone binding globulin and free testosterone increased (P<0.001) and the total IIEF increased (P = 0.017) with no differences between diets (P≥0.244). Increases in testosterone (P = 0.037) and sex hormone binding globulin (P<0.001) and improvements in the total IIEF (P = 0.041) occurred from weeks 0–12 with a further increase in testosterone from week 12–52 (P = 0.002). Increases in free testosterone occurred from week 12–52 (p = 0.002). The IIEF erectile functon domain, lower urinary tract symptoms and sexual desire did not change in either group (P≥0.126).ConclusionsIn overweight and obese men, weight loss with both high protein and carbohydrate diets improve testosterone, sex hormone binding globulin and overall sexual function.Trial RegistrationAnzctr.org.au ACTRN12606000002583

show abstract

Section: Discussioncontrasting

confidence: 99%

Long-Term Effects of a Randomised Controlled Trial Comparing High Protein or High Carbohydrate Weight Loss Diets on Testosterone, SHBG, Erectile and Urinary Function in Overweight and Obese Men

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Fourteen studies were conducted in people who were overweight but with no specific clinical condition, five in people with type 2 diabetes, two in participants with metabolic syndrome or impaired glucose regulation, one in men with type 2 diabetes and erectile dysfunction, and one in adults with developmental disabilities and obesity …”

Section: Resultsmentioning

confidence: 99%

“…In 15 studies (65%), the MR used consisted of specially formulated shakes, soups, or bars . In four studies (17%), the MR consisted of prepackaged portion‐controlled meals which participants reconstituted or cooked at home, and in four studies (17%), the MR was a combination of prepackaged portion‐controlled meals and specially formulated shakes, soups, or bars …”

Section: Resultsmentioning

confidence: 99%

A systematic review and meta‐analysis of the effectiveness of meal replacements for weight loss

et al. 2019

View full text Add to dashboard Cite

SummaryMeal replacements (MR) are generally not recommended in clinical guidelines for the management of obesity. The aim of this review is to provide an up‐to‐date systematic evaluation of the effect of weight loss interventions incorporating MR compared with alternative interventions on weight change at 1 year in adults with overweight or obesity. Six electronic databases were searched from inception to the end of August 2018 for randomized controlled trials comparing the effect of MR with interventions that did not include MR on weight at 1 year. We excluded studies using diets providing <3347 kJ/(800 kcal)/day and those which used total diet replacement (TDR) from this review. Risk of bias was assessed using the Cochrane risk of bias tool. Twenty‐three studies with 7884 adult participants were included. Six out of 23 studies were judged at low risk of bias across all domains, and 5/23 studies were judged at high risk of bias in at least one domain. Studies with similar intervention and comparators were grouped into five comparisons for analysis. Mean weight change at 1 year favoured the MR group relative to the control group in each comparison. In those comparisons where we conducted meta‐analysis, in people assigned to a diet incorporating MR, mean difference was −1.44 kg (−2.48 to −0.39 kg; I 2 = 38%) compared with alternative kinds of diets. In those assigned to a MR diet along with support, mean difference was −2.22 kg (−3.99 to −0.45, I 2 = 81%) compared with other diets with support and −3.87 kg (−7.34 to −0.40; I 2 = 60%) compared with other kinds of diet without support. In those assigned a MR diet with an enhanced level of support, mean difference was −6.13 kg (−7.35 to −4.91, I 2 = 19%) compared with alternative diets and regular support. Programmes incorporating meal replacements led to greater weight loss at 1 year than comparator weight loss programmes and should be considered as a valid option for management of overweight and obesity in community and health care settings.

show abstract

“…Physical adverse effects were reported in only a single study in which participants received very-low-calorie ketogenic diets, and these effects ceased when a normal diet was resumed. Only a single RCT [48] assessed mental health outcomes associated with dietary interventions for weight loss. This study compared the meal replacement Optifast to a conventional reduced-fat diet, and reported significant quality of life improvements in both groups.…”

Section: Resultsmentioning

confidence: 99%

A systematic review and narrative synthesis of interventions for uncomplicated obesity: weight loss, well-being and impact on eating disorders

Peckmezian¹,

Hay

2017

J Eat Disord

View full text Add to dashboard Cite

ObjectiveMost weight loss research focuses on weight as the primary outcome, often to the exclusion of other physiological or psychological measures. This study aims to provide a holistic evaluation of the effects from weight loss interventions for individuals with obesity by examining the physiological, psychological and eating disorders outcomes from these interventions.MethodsDatabases Medline, PsycInfo and Cochrane Library (2011–2016) were searched for randomised controlled trials and systematic reviews of obesity treatments (dietary, exercise, behavioural, psychological, pharmacological or surgical). Data extracted included study features, risk of bias, study outcomes, and an assessment of treatment impacts on physical, psychological or eating disorder outcomes.ResultsFrom 3628 novel records, 134 studies met all inclusion criteria and were evaluated in this review. Lifestyle interventions had the strongest evidence base as a first-line approach, with escalation to pharmacotherapy and bariatric surgery in more severe or complicated cases. Quality of life was the most common psychological outcome measure, and improved in all cases where it was assessed, across all intervention types. Behavioural, psychological and lifestyle interventions for weight loss led to improvements in cognitive restraint, control over eating and binge eating, while bariatric surgery led to improvements in eating behaviour and body image that were not sustained over the long-term.DiscussionNumerous treatment strategies have been trialled to assist people to lose weight and many of these are effective over the short-term. Quality of life, and to a lesser degree depression, anxiety and psychosocial function, often improve alongside weight loss. Weight loss is also associated with improvements in eating disorder psychopathology and related measures, although overall, eating disorder outcomes are rarely assessed. Further research and between-sector collaboration is required to address the significant overlap in risk factors, diagnoses and treatment outcomes between obesity and eating disorders.Electronic supplementary materialThe online version of this article (doi:10.1186/s40337-017-0143-5) contains supplementary material, which is available to authorized users.

show abstract

Comparing the effects of meal replacements with an isocaloric reduced‐fat diet on nutrient intake and lower urinary tract symptoms in obese men

Abstract: Weight loss as a result of CD or MR had similar efficacy in relieving LUTS. MR produced greater reductions in fat intake, adiposity and storage LUTS.

Cited by 9 publications

References 32 publications

Long-Term Effects of a Randomised Controlled Trial Comparing High Protein or High Carbohydrate Weight Loss Diets on Testosterone, SHBG, Erectile and Urinary Function in Overweight and Obese Men

Long-Term Effects of a Randomised Controlled Trial Comparing High Protein or High Carbohydrate Weight Loss Diets on Testosterone, SHBG, Erectile and Urinary Function in Overweight and Obese Men

A systematic review and meta‐analysis of the effectiveness of meal replacements for weight loss

A systematic review and narrative synthesis of interventions for uncomplicated obesity: weight loss, well-being and impact on eating disorders

Contact Info

Product

Resources

About