Comparing the effects of isotretinoin 20 mg versus azithromycin 500 mg in the management of acne vulgaris: a randomized clinical trial

Rajar, Uzma Dost Muhammad; Mashhood, Asher Ahmed; Fahim, Amin; Kazi, Navaid; Hanif, Muhammad Asif

doi:10.1111/ijd.16615

Cited by 1 publication

(2 citation statements)

References 15 publications

(33 reference statements)

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“…IPL treatment was turned out to be significantly better than clindamycin in lowering the value of hsa-mir-21. 16 However, in contrary to this a meta-analysis rigorously assesses IPL's effectiveness and safety in acne vulgaris management. Extensive database search yielded key studies.…”

Section: Discussionmentioning

confidence: 99%

“…Similar outcomes have been documented by Piccolo et al and other studies. 15,16 The study's limitations include a small sample size from a single hospital, a short one-week posttreatment follow-up. These limitations should be considered when interpreting the results of the study, and future research in this area should aim to address these issues to enhance the robustness and applicability of the findings.…”

Section: Discussionmentioning

confidence: 99%

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Intense Pulsed Light (IPL) therapy in acne vulgaris management: Assessing efficacy and safety.

Aqsa Naheed,

Tehseen Naveed,

Marwa Samee

et al. 2024

TPMJ

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Objective: To evaluate efficacy and safety of IPL in the treatment of Acne vulgaris. Study Design: Quasi-experimental study. Setting: CMH, Peshawar. Period: 15th January 23 to 15th May 23. Material & Methods: 35 participants having acne vulgaris with age range from 18-35 years were selected. Participants who had used any form of topical, oral, or alternative treatments for acne, including retinoids, within the six months preceding the commencement of the study, history of systemic steroid intake, photosensitivity and herpes simplex, were excluded. Global Acne Grading System (GAGS) score was used to ascertain the severity of acne vulgaris. Four sessions of weekly Intense Pulsed Light (IPL) sessions, utilizing filters of 420nm, 510nm and 560nm for participants having skin type III, IV and V respectively were employed. GAGS score was calculated one week after the last session. Side effects were recorded, degree of improvement and patient reported outcome was noted using a four-point scale limited =<25%, marked =25%-50%, promising 50-75% and profound =>75%. Results: Mean age of participants was 21.63 ± 4.63 years, with a mean duration of acne was 4.26 ± 2.20 years. The mean baseline GAGS score I decreased from 22.00±5.26 to 11.58±4.80, as observed one week following the last IPL session. The calculated p-value was statistically significant (<0.000). 54% of patients encountered no adverse reactions. Conclusion: Intense Pulsed Light (IPL) emerges as a secure and efficacious treatment choice, particularly in the initial stages, to enhance the response to therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%