“…Survanta well replicates the surface tension-lowering properties of natural lung surfactant and has been clinically used in treating respiratory distress syndrome. 25 In the presence of lung surfactant, the MICs of polymyxin B 1 (as a representative of polymyxins) increased by 8-, 4-, and 4-fold against P. aeruginosa, K. pneumoniae, and A. baumannii, respectively (Figure 1A), indicating the potential influence of lung surfactant on the efficacy of polymyxins against pulmonary infection.…”