Comparing Respiratory Gated With Delayed Scans in the Detection of Colorectal Carcinoma Hepatic and Pulmonary Metastases With 18F-FDG PET-CT

Hassler, S.; Hubelé, F.; Constantinesco, A.; Goetz, Christian

doi:10.1097/rlu.0b013e31828e96dd

Cited by 10 publications

(2 citation statements)

References 28 publications

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“…Hepatic carcinoma (HCC) has been considered as the fifth common cancer type and ranked as the third leading cause of cancer deaths in the world. 1,2 Molecular imaging of HCC currently includes computed tomography (CT), 3−5 ultrasonography, 6,7 nuclear medicine imaging, 8,9 and magnetic resonance imaging. 10−12 X-ray-based CT has been regarded as one of the most common molecular imaging methods, which affords deep tissue penetration and high three-dimensional resolution.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Hepatic carcinoma (HCC) has been considered as the fifth common cancer type and ranked as the third leading cause of cancer deaths in the world. , Molecular imaging of HCC currently includes computed tomography (CT), − ultrasonography, , nuclear medicine imaging, , and magnetic resonance imaging. − X-ray-based CT has been regarded as one of the most common molecular imaging methods, which affords deep tissue penetration and high three-dimensional resolution. − Because of the inherently low sensitivity in CT imaging of soft tissues, administration of a certain amount of contrast agent is frequently required for the accurate diagnosis with high contrast. Currently, small iodinated molecular CT contrast agents are routinely utilized in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

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Acetylated Polyethylenimine-Entrapped Gold Nanoparticles Enable Negative Computed Tomography Imaging of Orthotopic Hepatic Carcinoma

et al. 2018

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Developing an effective computed tomography (CT) contrast agent is still a challenging task for precise diagnosis of hepatic carcinoma (HCC). Here, we present the use of acetylated polyethylenimine (PEI)-entrapped gold nanoparticles (Ac-PE-AuNPs) without antifouling modification for negative CT imaging of HCC. PEI was first linked to fluorescein isothiocyanate (FI) and then utilized as a vehicle for the entrapment of AuNPs. The particles were then acetylated to reduce its positive surface potential. The designed Ac-PE-AuNPs were characterized by various techniques. We find that the Ac-PE-AuNPs with a uniform size distribution (mean diameter = 2.3 nm) are colloidally stable and possess low toxicity in the studied range of concentration. Owing to the fact that the particles without additional antifouling modification were mainly gathered in liver, the Ac-PE-AuNPs could greatly improve the CT contrast enhancement of normal liver, whereas poor CT contrast enhancement appeared in liver necrosis region caused by HCC. As a result, HCC could be easily and precisely diagnosed. The designed Ac-PE-AuNPs were demonstrated to have biocompatibility through in vivo biodistribution and histological studies, hence holding an enormous potential to be adopted as an effective negative CT contrast agent for diagnosis of hepatoma carcinoma.

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