Comparing remifentanil and sufentanil in stress reduction during neurosurgery: a randomised controlled trial

Liu, Yiheng; Hu, Xiaobing; Yang, Xiamin; Wang, Yingwei; Deng, Mengying

doi:10.1007/s11096-020-01094-1

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…At present, the clinical therapy of ADD of the TMJ is mainly small incision reduction and suture, which will bring some disadvantages and cannot be treated accurately. With the gradual development of medical technology, the improvement of small incision reduction and suture in the past therapy process, which can effectively treat the changes in the lower position of sufferers, has now made a major breakthrough and achieved noteworthy therapeutic impacts [19][20][21][22]. In the process of therapy with functional instruments, both its accuracy and feasibility can be well guaranteed, which provides a sufficient scientific basis for guiding the therapy of sufferers' mandibular joints, and can effectively solve sufferers' pain feelings [23].…”

Section: Discussionmentioning

confidence: 99%

Impact of Small Incision Reduction and Suture Linked with Functional Appliance of Sufferers with Irrecoverable TMJ Anterior Disc Displacement

Wei

Yan

Sun

et al. 2022

Computational and Mathematical Methods in Medicine

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Background and Aim. Irrecoverable anterior disc displacement (ADD) of temporomandibular joint (TMJ) seriously affects the quality of life of patients. This research was aimed to explore the recovery effect of small incision reduction and suture on patients. Methods. 90 patients with irreducible ADD of TMJ treated from August 2020 to August 2021 were acquired in our hospital. They were randomly divided into control group and trial group randomly. There were 45 patients in each group. The sufferers in the control group were treated with oral drug therapy and small incision reduction and suture, while those in the trial group were treated with small incision reduction and suture linked with functional appliance. The pain score, dysfunction, joint function recovery, facial improvement, and clinical impacts of the two groups were contrasted. Results. Compared with that in the control group at 1 week, 4 weeks, and 6 months after therapy, the pain score in the trial group was markedly higher. After therapy, in the two groups, maximum vertical opening (MVO), left lateral excursion (LLE), and right lateral excursion (RLE) levels were markedly higher than those in the control group. The MRI score of the trial group was markedly higher than that of the control group at 1 week, 4 weeks, and 6 months after therapy, and the total effective rate of the trial group was markedly higher than that of the control group. Conclusion. The use of small incision reduction and suture linked with functional appliance in the therapy of sufferers with irreducible ADD of TMJ is beneficial to relieve pain, promote the recovery of body function, and contribute to the recovery of joint function.

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Section: Discussionmentioning

confidence: 99%

Impact of Small Incision Reduction and Suture Linked with Functional Appliance of Sufferers with Irrecoverable TMJ Anterior Disc Displacement

Wei

Yan

Sun

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Thus, clarifying the optimal dose of sufentanil can better provide theoretical basis and specific guidance for clinical application [ 4 ]. The latest opioid receptor agonist drug remifentanil, which has the advantages of fast acting, short-acting time, and no accumulation during continuous infusion, has been widely used in clinical [ 5 ]. Importantly, remifentanil is generally well tolerated with a low incidence of respiratory depression.…”

Section: Introductionmentioning

confidence: 99%

Effects of Remifentanil and Sufentanil Anesthesia on Cardiac Function and Serological Parameters in Congenital Heart Surgery

Qin

2021

Journal of Healthcare Engineering

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In this study, we have investigated feasibility of remifentanil and sufentanil anesthesia in children with congenital heart disease surgery and its effects on cardiac function and serological parameters. For this purpose, a retrospective study was conducted on 120 children with congenital heart disease who underwent repair of ventricular septum or atrial septum in our hospital, specifically from January 2016 to January 2018, and 60 patients in each group were randomly divided into the control and treatment groups, respectively. The control group was anesthetized with sufentanil, and the treatment group was anesthetized with remifentanil. The heart function, serological indexes, and adverse reactions were observed and compared. We have observed that there was no significant difference in HR levels between these groups ( P > 0.05 ), but SDP and DBP values of the two groups were decreased after anesthetic induction ( P < 0.05 ). ACH, cortisol, and lactic acid in the treatment group were significantly lower than those in the control group, and the difference was statistically significant ( P < 0.05 ). The incidence of bradycardia, nausea and vomiting, hypotension, muscle rigidity, and respiratory depression in the treatment group was 16.67% lower than that in the control group ( P < 0.05 ). Remifentanil has less influence on hemodynamics and a better analgesic effect than fentanyl in inhibiting stress response in congenital heart surgery, which provides reference and basis for children congenital heart surgery.

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“…Stress biomarkers, such as epinephrine, norepinephrine, cortisol, interleukin-6, and interleukin-10, showed no difference between the remifentanil and sufentanil groups 1 h after incision or at the end of surgery in patients anesthetized with remifentanil or sufentanil titrated to maintain hemodynamic parameters within 20% of the baseline combined with the same propofol regimen [ 17 ]. This result indicates that the inhibitory ability of stress hormones induced by the surgical simulation of remifentanil and sufentanil is similar when controlled according to the same hemodynamic target.…”

Section: Discussionmentioning

confidence: 99%

“…Sufentanil or remifentanil was discontinued 10 min before the anticipated end of the surgery, and the median time from opioid discontinuation to extubation was 15 min in both groups. In addition, compared with previous studies, sufentanil- and remifentanil-TCI were administered at fixed plasma concentrations of 0.1 ng/ml and 1 ng/ml, respectively, which are lower maintenance doses [ 14 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of intraoperative remifentanil and sufentanil infusion on postoperative pain management in robotic gynecological surgery: a retrospective cohort study

Sung,

Jee,

Cho

et al. 2023

Anesth Pain Med

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Background: Remifentanil and sufentanil are potent short-acting synthetic opioid analgesics. The administration of remifentanil has been associated with the incidence of opioid-induced hyperalgesia. Opioid-induced hyperalgesia may be alleviated when opioids, such as morphine, are switched to sufentanil. Therefore, this retrospective observational study aimed to compare the effects of remifentanil and sufentanil on postoperative pain in patients undergoing robotic gynecological surgery. Methods: We retrospectively analyzed the electronic medical records of patients who underwent elective robotic gynecological surgery between January 2016 and February 2021. The patients were classified into sufentanil (n = 159) or remifentanil (n = 359) groups according to the opioids administered continuously during anesthesia. The primary outcome assessed in this study was the postoperative pain score measured using the numeric rating scale (NRS). The secondary outcomes assessed included the recovery time (from discontinuation of opioid infusion to extubation) and frequency of rescue analgesic administration in the post-anesthesia care unit (PACU). Results: The recovery time did not differ significantly between the two groups. The NRS score for pain (median [1Q, 3Q]) in the PACU was significantly lower in the sufentanil group than in the remifentanil group (2 [2, 3] vs. 4 [3, 7], P < 0.001). The frequency of rescue analgesic administration in the PACU was 6.3% and 35.4% in the sufentanil and remifentanil groups, respectively (P < 0.001). Conclusions: Sufentanil, as an adjunct to sevoflurane anesthesia is more advantageous than remifentanil in terms of postoperative pain control during robotic gynecological surgery.

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Comparing remifentanil and sufentanil in stress reduction during neurosurgery: a randomised controlled trial

Cited by 6 publications

References 34 publications

Impact of Small Incision Reduction and Suture Linked with Functional Appliance of Sufferers with Irrecoverable TMJ Anterior Disc Displacement

Impact of Small Incision Reduction and Suture Linked with Functional Appliance of Sufferers with Irrecoverable TMJ Anterior Disc Displacement

Effects of Remifentanil and Sufentanil Anesthesia on Cardiac Function and Serological Parameters in Congenital Heart Surgery

Comparison of the effects of intraoperative remifentanil and sufentanil infusion on postoperative pain management in robotic gynecological surgery: a retrospective cohort study

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