Comparing rat’s to human’s age: How old is my rat in people years?

Quinn, Robert H.

doi:10.1016/j.nut.2005.04.002

Cited by 583 publications

(437 citation statements)

References 4 publications

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“…In our rat model of bariatric surgery with gastric banding, we have documented that in the course of 21 days after operation, which is comparable to that observed over 2 years in human patients [55], animals reduced their food intake and body weight in comparison to obese controls while also restored normal feeding behavior after fasting. Furthermore, fasting ghrelin levels did not increase when compared to sham-operated animals fed ad libitum and were significantly lower than the levels presented by weight-matched food-restricted (pair-fed) rats.…”

Section: Discussionsupporting

confidence: 74%

Increase in Ghrelin Levels After Weight Loss in Obese Zucker Rats is Prevented by Gastric Banding

et al. 2007

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Background Gastric banding is thought to decrease appetite in addition to the mechanical effects of food restriction, although this has been difficult to demonstrate in human studies. Our aim was to investigate the changes in orexigenic signals in the obese Zucker rat after gastric banding. Methods Obese Zucker rats ( fa/fa) were submitted to gastric banding (GBP), sham gastric banding fed ad libitum (sham), or sham operation with food restriction, pair-fed to the gastric banding group (sham-PF). Lean Zucker rats ( fa/+) were used as additional controls. Body weight and food intake were daily recorded for 21 days after surgery when epididymal fat was weighed and fasting ghrelin and hypothalamic NPY mRNA expression were measured. Results Gastric banding in obese Zucker rats resulted in a significant decrease of cumulative body weight gain and food intake. Furthermore, gastric banded rats were leaner than Sham-PF, as expressed by a significantly lower epididymal fat weight. Ghrelin levels of gastric banded rats were not increased when compared to sham-operated animals fed ad libitum and were significantly lower than the levels of weight matched sham-PF rats (1116.9±103.3 g GBP vs 963.2±54.3 g sham, 3,079.5±221.6 sham-PF and 2,969.9±150.9 g lean rats, p<0.001); hypothalamic NPY mRNA expression was not increased in GBP when compared to sham-operated rats. Conclusion In obese Zucker rats, GBP prevents the increase in orexigenic signals that occur during caloric deprivation. Our data support the hypothesis that sustained weight loss observed after gastric banding does not depend solely on food restriction.

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Section: Discussionsupporting

confidence: 74%

Increase in Ghrelin Levels After Weight Loss in Obese Zucker Rats is Prevented by Gastric Banding

et al. 2007

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“…In the present study, the animals of the last group had reached the end of the follow-up time at 24 months of life, thus, on the basis of its cycle of life, they can be considered elderly rats 11 . The development of the animals based on their weight was considered adequate regarding the standard curves found in…”

Section: Discussionmentioning

confidence: 98%

Quantitative analysis of the renal aging in rats. Stereological study

et al. 2016

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Brazil. Scientific, intellectual, conception and design of the study; analysis and interpretation of data; statistics analysis; critical revision. ABSTRACT PURPOSE:To evaluate the renal function and the renal histological alterations through the stereology and morphometrics in rats submitted to the natural process of aging. METHODS:Seventy two Wistar rats, divided in six groups. Each group was sacrificed in a different age: 3, 6, 9, 12, 18 and 24 months.It was performed right nephrectomy, stereological and morphometric analysis of the renal tissue (renal volume and weight, density of volume (Vv [glom] ) and numerical density (Nv [glom] ) of the renal glomeruli and average glomerular volume (Vol [glom] )) and also it was evaluated the renal function for the dosage of serum creatinine and urea. RESULTS:There was significant decrease of the renal function in the oldest rats. The renal volume presented gradual increase during the development of the rats with the biggest values registered in the group of animals at 12 months of age and significant progressive decrease in older animals. Vv [glom] presented statistically significant gradual reduction between the groups and the Nv [glom] also decreased significantly. CONCLUSIONS:The renal function proved to be inferior in senile rats when compared to the young rats. The morphometric and stereological analysis evidenced renal atrophy, gradual reduction of the volume density and numerical density of the renal glomeruli associated to the aging process.Key words: Aging. Kidney. Histology. Rats.Quantitative analysis of the renal aging in rats. Stereological study Acta

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“…The age of 16 and 80 weeks of rats are compatible to 18 and 60 years old in humans [19]. Animals were maintained in laminar flow cages in a specific pathogenfree animal facility at the University of Pittsburgh and fed a standard diet and water ad libitum.…”

Section: Animalsmentioning

confidence: 99%

“…In clinical studies, CEL allowed for better posttransplant heart recovery and accounted for fewer incidences of vasculopathy and chronic rejection compared with CEL and University of Wisconsin solution in the midterm follow-up [16]. In a single-center, randomized study comparing CEL and HTK solution in 48 heart transplant recipients (24 patients in each group) [19], the onset of a spontaneous and stable sinus rhythm after reperfusion of the heart allograft was seen more rapidly in the CEL patients than HTK. In contrast, in a trial with 224 patients [18], a trend toward decreased need for inotropic agents after preservation with HTK compared with CEL and University of Wisconsin solution occurred.…”

Section: Commentmentioning

confidence: 99%

Histidine-Tryptophan-Ketoglutarate or Celsior: Which Is More Suitable for Cold Preservation for Cardiac Grafts From Older Donors?

Lee

Huang

Kawamura

et al. 2011

The Annals of Thoracic Surgery

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Background. The growing number of patients awaiting heart transplantation, coupled with the worldwide donor shortage, has led to increased use of marginal organs, specifically hearts from older donors. This study compared the protective effects of two widely used preservation solutions, histidine-tryptophan-ketoglutarate (HTK) and Celsior (CEL; Sangstat Medical, Menlo Park, CA), for ischemia-reperfusion injury using a rat heterotopic heart transplantation model with older donors.Methods. The hearts were excised from 16-and 80-week-old Lewis donor rats, stored in HTK, CEL, or saline for 6 hours and heterotopically transplanted into syngenic young Lewis recipients. Serum troponin I and creatine phosphokinase, graft infiltrating cells, graft apoptosis, graft proinflammatory messenger ribonucleic acid levels, and adenosine monophosphate-activated protein kinase phosphorylation were analyzed 3, 6, and 12 hours after reperfusion as markers of graft injury.

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Comparing rat’s to human’s age: How old is my rat in people years?

Cited by 583 publications

References 4 publications

Increase in Ghrelin Levels After Weight Loss in Obese Zucker Rats is Prevented by Gastric Banding

Increase in Ghrelin Levels After Weight Loss in Obese Zucker Rats is Prevented by Gastric Banding

Quantitative analysis of the renal aging in rats. Stereological study

Histidine-Tryptophan-Ketoglutarate or Celsior: Which Is More Suitable for Cold Preservation for Cardiac Grafts From Older Donors?

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