Comparing multichannel cylinder and 3D-printed applicators for vaginal cuff brachytherapy with preliminary exploration of post-hysterectomy vaginal morphology

Yan, Jun; Qin, Xue; Zhang, Fuquan; Hou, Xiaorong; Yu, Lu; Qin, Jie

doi:10.5114/jcb.2021.112115

Cited by 8 publications

(10 citation statements)

References 40 publications

(59 reference statements)

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“…MCC applicators have become more popular because of their dose exibility [4]. However, the vagina may not be cylindrical because of surgery and anatomic irregularities [3]. Furthermore, MCC applicators are limited to various applications owing to air gaps.…”

Section: Discussionmentioning

confidence: 99%

“…Personalized vaginal applicators are one choice to overcome the limitations of MCC applicators [12]. Yan et al showed that 3D-printed applicators obtained signi cant improvements in CTV-1 cm V100 (by 13%) and D90 (by 11%) when compared to MCC; 3D-printed applicators demonstrated superiority over MCC in terms of OARs protection [3]. In addition, the advantages of 3D-printing technology include versatility, costeffectiveness, and accuracy [10].…”

Section: Discussionmentioning

confidence: 99%

“…Vaginal cuff brachytherapy (VBT) has become a standard adjuvant treatment for EC with a high risk of recurrence after resection [2]. Vaginal applicators are tools for performing VBT and are the most commonly used single-channel cylinders (SCC) [3]. However, SCC sometimes delivers inadequate dose coverage to the vaginal apex owing to source anisotropy [4].…”

Section: Introductionmentioning

confidence: 99%

“…However, SCC sometimes delivers inadequate dose coverage to the vaginal apex owing to source anisotropy [4]. Creating individualized applicators for different patients using three-dimensional (3D) printing technology achieves satisfactory dose distribution [3]. HerlynWernerWunderlich syndrome (HWWS) is a congenital malformation of the uterus, didelphys cervix, didelphys vagina, and complete or incomplete atresia of one vagina [5].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Personalized brachytherapy for a Herlyn-Werner-Wunderlich syndrome patient with endometrial cancer: A case report

Zeng

Zhang

et al. 2023

Preprint

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Background: Endometrial carcinoma (EC) is a common gynecological malignancy. Vaginal cuff brachytherapy (VBT) is an adjuvant treatment for EC. Because a single-channel cylinder sometimes delivers inadequate dose coverage to the vaginal apex, three-dimensional (3D)-printing technology can be used to achieve satisfactory dose distribution. Here, we report the first case of an EC patient with Herlyn-Werner-Wunderlich syndrome (HWWS) treated with VBT using 3D-printed applicators. Case presentation: Here, we present a case study of endometrial cancer patient with Herlyn‑Werner‑Wunderlich syndrome who underwent surgery. During adjuvant radiotherapy, 3D-printed applicators were used in vaginal cuff brachytherapy. To accomplish the reconstruction of the source pathways on MRI, catheters with copper sulfate were placed in two 3D-printed applicators. The early tolerance of this treatment was positive. During the 6-month follow-up, locoregional recurrence was not detected. Conclusions: Our findings strongly indicate that VBT with 3D-printed applicators may be a reasonable treatment option for EC with HWWS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Personalized brachytherapy for a Herlyn-Werner-Wunderlich syndrome patient with endometrial cancer: A case report

Zeng

Zhang

et al. 2023

Preprint

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“…With the development of POVBT techniques, a rich variety of applicators with different shapes (e.g., cylindrical, irregular, or spherical) and materials (polyphenylsulfone plastic, photopolymer, acrylic, or salinefilled) [9][10][11][12] have emerged. The diversity of applicators makes it difficult to create an automatic segmentation model of POVBT.…”

Section: Discussionmentioning

confidence: 99%

Auto‐segmentation of the clinical target volume using a domain‐adversarial neural network in patients with gynaecological cancer undergoing postoperative vaginal brachytherapy

Yan,

Qin,

Qiao

et al. 2023

Precision Radiation Oncology

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PurposeFor postoperative vaginal brachytherapy (POVBT), the diversity of applicators complicates the creation of a generalized auto‐segmentation model, and creating models for each applicator seems difficult due to the large amount of data required. We construct an auto‐segmentation model of POVBT using small data via domain‐adversarial neural networks (DANNs).MethodsCT images were obtained postoperatively from 90 patients with gynaecological cancer who underwent vaginal brachytherapy, including 60 and 30 treated with applicators A and X, respectively. A basal model was devised using data from the patients treated with applicator A; next, a DANN model was constructed using these same 60 patients as well as 10 of those treated with applicator X through transfer learning techniques. The remaining 20 patients treated with applicator X comprised the validation set. The model's performance was assessed using objective metrics and manual clinical evaluation.ResultsThe DANN model outperformed the basal model on both objective metrics and subjective evaluation (p<0.05 for all). The median DSC and 95HD values were 0.97 and 3.68 mm in the DANN model versus 0.94 and 5.61 mm in the basal model, respectively. Multi‐centre subjective evaluation by three clinicians showed that 99%, 98%, and 81% of CT slices contoured by the DANN model were acceptable versus only 73%, 77%, and 57% of those contoured by the basal model. One clinician deemed the DANN model comparable to manual delineation.ConclusionDANNs provides a realistic approach for the wide application of automatic segmentation of POVBT and can potentially be used to construct auto‐segmentation models from small datasets.

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Evaluating the relationship between vaginal apex “dog ears” and patterns of recurrence in endometrial cancer following adjuvant image guided vaginal cuff brachytherapy

Venner¹,

Ward²,

Wages³

et al. 2023

Brachytherapy

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Comparing multichannel cylinder and 3D-printed applicators for vaginal cuff brachytherapy with preliminary exploration of post-hysterectomy vaginal morphology

Cited by 8 publications

References 40 publications

Personalized brachytherapy for a Herlyn-Werner-Wunderlich syndrome patient with endometrial cancer: A case report

Personalized brachytherapy for a Herlyn-Werner-Wunderlich syndrome patient with endometrial cancer: A case report

Auto‐segmentation of the clinical target volume using a domain‐adversarial neural network in patients with gynaecological cancer undergoing postoperative vaginal brachytherapy

Evaluating the relationship between vaginal apex “dog ears” and patterns of recurrence in endometrial cancer following adjuvant image guided vaginal cuff brachytherapy

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