Comparing methods to collect saliva from children to analyze cytokines related to allergic inflammation

Hiremath, Girish; Olivé, Anthony; Shah, Samir D.; Davis, Carla M.; Shulman, Robert J.; Devaraj, Sridevi

doi:10.1016/j.anai.2014.09.012

Cited by 13 publications

(9 citation statements)

References 9 publications

(6 reference statements)

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“…While information on the acceptability and feasibility of salivary cortisol collection in community samples of children is limited, research conducted in other populations and with other biomarkers provides additional insight that may be used to improve salivary cortisol collection methods. In a study comparing saliva collection methods for inflammatory cytokines, researchers found that children age 9–17 years preferred the oral swab method to passive drool, reporting oral swabs were quicker and easier to use (Hiremath et al, ). In a qualitative study of parental receptivity to child biomarker testing for tobacco smoke, researchers found that opposition to testing was associated with reluctance to cause short‐term discomfort, perceived powerlessness, and mistrust of research (Rosen et al, ).…”

Section: Discussionmentioning

confidence: 99%

Psychosocial Influences on Acceptability and Feasibility of Salivary Cortisol Collection From Community Samples of Children

Condon

2016

Research in Nursing & Health

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Salivary cortisol is considered to be a safe and noninvasive measure of hypothalamic-pituitary-adrenal axis functioning, and is a commonly measured biomarker of the human stress response in pediatric research. However, cortisol is highly variable and sensitive to a wide range of factors, creating a challenge for reliable salivary cortisol collection in the community setting. Furthermore, the acceptability of salivary cortisol collection in community samples of children is largely unknown. The purpose of this integrative review was to investigate current evidence on the acceptability and feasibility of salivary cortisol collection in community samples of children. In an analysis framed by the Theory of Planned Behavior, data extracted from 31 studies revealed six categories of psychosocial influences on acceptability and feasibility: uncertainty and misconceptions, cultural and ethnic values, family rules and values, difficulty following protocols and procedures, burden of multiple samples, and child refusal or resistance. Further research is required to fully understand the factors that influence acceptability and feasibility of salivary cortisol collection in community samples of children. Understanding individual, family, and community perceptions of biobehavioral research will lead to more culturally sensitive and feasible community-based research methods.

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Section: Discussionmentioning

confidence: 99%

Psychosocial Influences on Acceptability and Feasibility of Salivary Cortisol Collection From Community Samples of Children

Condon

2016

Research in Nursing & Health

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“…Next‐generation enzyme‐linked immunosorbent assays (ELISAs) were used to evaluate levels of four cytokines in infant saliva: C‐X‐C motif chemokine ligand (CXCL)‐10, interleukin (IL)‐18, IL‐6, and IL‐8. These analytes were selected based on their bioavailability in saliva, and their potential relevance to allergic conditions 18,19 …”

Section: Methodsmentioning

confidence: 99%

“…These analytes were selected based on their bioavailability in saliva, and their potential relevance to allergic conditions. 18,19…”

Section: Cytokine Analysismentioning

confidence: 99%

Understanding immunological origins of atopic dermatitis through multi‐omic analysis

Beheshti

Halstead

McKeone

et al. 2022

Pediatric Allergy Immunology

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Atopic dermatitis (AD) is a chronic inflammatory skin condition impacting approximately 15% of children worldwide. 1 The incidence of AD has increased over the last 50 years, with approximately 60% of individuals developing symptoms in the first 12 months of life. 2 Predisposition to AD may be influenced by medical and demographic traits, environmental factors, and underlying immunologic phenotypes.Epidermal barrier breakdown is a key driver of AD. 3 Causes of epidermal breakdown are multifactorial, resulting from genetic,

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“…The notable clinical features of saliva include its ease of collection and non-invasive accessibility. Indeed, saliva is widely used for measuring the concentrations of hormones, cytokines, and other physiological active substances (Nie et al 2014;Hiremath et al 2015;Langie et al 2016). Salivation in the oral cavity is induced as a neural reflex in the body.…”

Section: Discussionmentioning

confidence: 99%

Gustatory Salivation Is Associated with Body Mass Index, Daytime Sleepiness, and Snoring in Healthy Young Adults

Izumi

Hong

Iwasaki³

et al. 2016

Tohoku J. Exp. Med.

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The taste detection system for oral fatty acid may be related to obesity. In addition, sleep is intrinsically and closely related to food intake and metabolism. However, the association of gustatory salivation with body mass index (BMI), daytime sleepiness, or sleep habits is largely unknown. Therefore, we evaluated the relationship between gustatory salivation and BMI, Epworth sleepiness scale (ESS, a daytime sleepiness scale) or sleep habits among 26 healthy young individuals (20 males and 6 females; mean age: 26.0 ± 4.3 years). We also measured the saliva flow rate (SFR) that was induced by gum-chewing or each of three prototypical tastants (acetic acid, sucrose, and NaCl). Further, the SFR was induced by fatty acid, provided as oleic acid (OA) homogenized in non-fat milk. All participants showed normal rates of salivation during resting and gum-chewing states. The increase in the SFR induced by OA, but not by each of the three tastants, was associated with BMI. Moreover, both daytime sleepiness level and frequency of snoring were associated with the increase in the SFR induced by NaCl. These results suggest that BMI is associated with salivation induced by oral fatty acid exposure. Additionally, the regulatory mechanism for the NaClinduced salivation reflex may have a relationship with impairments of the respiratory control system that are related to snoring during sleep and lead to daytime sleepiness because of insufficient sleep. Thus, measurement of gustatory salivation might contribute to the evaluation and prevention of obesity and sleeprelated breathing disorders.

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Comparing methods to collect saliva from children to analyze cytokines related to allergic inflammation

Cited by 13 publications

References 9 publications

Psychosocial Influences on Acceptability and Feasibility of Salivary Cortisol Collection From Community Samples of Children

Psychosocial Influences on Acceptability and Feasibility of Salivary Cortisol Collection From Community Samples of Children

Understanding immunological origins of atopic dermatitis through multi‐omic analysis

Gustatory Salivation Is Associated with Body Mass Index, Daytime Sleepiness, and Snoring in Healthy Young Adults

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