Comparing Localization of Conventional Functional Magnetic Resonance Imaging and Magnetoencephalography

Beisteiner, Roland; Gomišček, Gregor; Erdler, Marcus; Teichtmeister, C.; Moser, Ewald; Deecke, Lüder

doi:10.1111/j.1460-9568.1995.tb01101.x

Cited by 64 publications

(27 citation statements)

References 21 publications

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“…In previously published reports the distances between main fMR imaging activity and the MEG dipole localization in preoperative localization studies have been shown to vary between 10 mm and 16 mm. [2,26] These differences correlate with our own investigations (unpublished data) in which we determined that the mean difference between fMR imaging and MEF/MEG in motor tasks is 14 mm. However, the measured blood oxygen level-dependent effect in fMR imaging tends to have its highest activity within or posterior to the central sulcus due to the individual venous architecture of the motor cortex.…”

Section: Discussionsupporting

confidence: 78%

Functional neuronavigation with magnetoencephalography: outcome in 50 patients with lesions around the motor cortex

Ganslandt

Fahlbusch²,

Nimsky³

et al. 1999

FOC

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The authors conducted a study to evaluate the clinical outcome in 50 patients with lesions around the motor cortex who underwent surgery in which functional neuronavigation was performed. The sensorimotor cortex was identified in all patients with the use of magnetoencephalography (MEG). The MEG-source localizations were superimposed onto a three-dimensional magnetic resonance image, and the image data set was then implemented into a neuronavigation system. Based on this setup, the surgeon chose the best surgical strategy. During surgery, the pre- and postcentral gyrus were identified by neuronavigation, and in addition, the central sulcus was localized using intraoperative recording of somatosensory evoked potentials. In all cases MEG localizations of the sensory or motor cortex were correct. In 30% of the patients preoperative paresis improved, in 66% no additional deficits occurred, and in only 4% (two patients) deterioration of neurological function occurred. In one of these patients the deterioration was not related to the method. The method of incorporating functional data into neuronavigation systems is a promising tool that can be used in more radical surgery to cause less morbidity around eloquent brain areas.

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Section: Discussionsupporting

confidence: 78%

Functional neuronavigation with magnetoencephalography: outcome in 50 patients with lesions around the motor cortex

Ganslandt

Fahlbusch²,

Nimsky³

et al. 1999

FOC

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“…For the contralateral SI, the disagreement was of the same order of magnitude as in previous studies comparing fMRI and MEG activation of the motor cortex [Sanders et al, 1996;Beisteiner et al, 1995]. For the other areas, the differences in localization were in some cases larger (see Table I).…”

Section: Comparison Of Fmri and Meg Localizations: Technical Aspectsmentioning

confidence: 66%

“…Localization of the hemodynamic responses could then give independent confirmation to electrophysiological source localization, and could be used to constrain the inverse problem solutions of MEG or EEG [Dale and Sereno, 1993;Hämäläinen et al, 1993;George et al, 1995;Ilmoniemi, 1995;Kwong, 1995;Simpson et al, 1995;Liu et al, 1998]. Recently, the location of the hand area of the primary motor cortex has been determined jointly with MEG and fMRI [Beisteiner et al, 1995;Sanders et al, 1996;Stippich et al, 1998]. These studies gave a mean difference in location of less than 10-16 mm between the two techniques.…”

Section: Introductionmentioning

confidence: 98%

Activation of multiple cortical areas in response to somatosensory stimulation: Combined magnetoencephalographic and functional magnetic resonance imaging

et al. 1999

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We combined information from functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) to assess which cortical areas and in which temporal order show macroscopic activation after right median nerve stimulation. Five healthy subjects were studied with the two imaging modalities, which both revealed significant activation in the contra- and ipsilateral primary somatosensory cortex (SI), the contra- and ipsilateral opercular areas, the walls of the contralateral postcentral sulcus (PoCS), and the contralateral supplementary motor area (SMA). In fMRI, two separate foci of activation in the opercular cortex were discerned, one posteriorly in the parietal operculum (PO), and one anteriorly near the insula or frontal operculum (anterior operculum, AO). The activation sites from fMRI were used to constrain the solution of the inverse problem of MEG, which allowed us to construct a model of the temporal sequence of activation of the different sites. According to this model, the mean onset latency for significant activation at the contralateral SI was 20 msec (range, 17-22 msec), followed by activation of PoCS at 23 msec (range, 21-25 msec). The contralateral PO was activated at 26 msec (range, 19-32 msec) and AO at 33 msec (range, 22-51 msec). The contralateral SMA became active at 36 msec (range, 24-48 msec). The ipsilateral SI, PO, and AO became activated at 54-67 msec. We conclude that fMRI provides a useful means to constrain the inverse problem of MEG, allowing the construction of spatiotemporal models of cortical activation, which may have significant implications for the understanding of cortical network functioning.

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“…However, the localization accuracy of FMRI is unknown at present; because of the various sources of artifacts, it might be in the millimeter or centimeter range. Quantitative data reviewed here showed an average FMRI-MEG difference of 8.8 mm in the study of Sanders et al [22] and an average FMRI-MEG difference 16.7 mm in the study of Beisteiner et al [24]. Although both groups used FLASH sequences and a 1.5-T Magnetom, important methodologic differences exist.…”

Section: Discussionmentioning

confidence: 71%

“…Therefore, the area of activation was much larger in the study of Beisteiner et al, and therefore individual FMRI pixel cannot be definitively attributed to pre-or postcentral activity. Data taken from the study of Beisteiner et al [24]. (b) Coronal section of the same subject.…”

Section: Discussionmentioning

confidence: 99%

Evaluating conventional FMRI with respect to noninvasive localization of neuronal activity

Beisteiner

Erdler

Teichtmeister

et al. 1995

Int J Imaging Syst Tech

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Conventional functional magnetic resonance imaging (FMRI) allows the measurement of functional cerebral blood flow changes occurring with specific tasks using standard clinical MR systems. However, the spatial relationship between neuronal activity and functional cerebral blood flow changes is not yet known. This article reviews studies which compared the center of neuronal activation (measured by magnetoencephalography) with that of the hemodynamic response (measured by FMRI) using motor and visual stimulation. 0 1995 John Wiley 8 Sons, Inc.

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Comparing Localization of Conventional Functional Magnetic Resonance Imaging and Magnetoencephalography

Cited by 64 publications

References 21 publications

Functional neuronavigation with magnetoencephalography: outcome in 50 patients with lesions around the motor cortex

Functional neuronavigation with magnetoencephalography: outcome in 50 patients with lesions around the motor cortex

Activation of multiple cortical areas in response to somatosensory stimulation: Combined magnetoencephalographic and functional magnetic resonance imaging

Evaluating conventional FMRI with respect to noninvasive localization of neuronal activity

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