Comparing Efficacy and Costs of Four Facial Fillers in Human Immunodeficiency Virus–Associated Lipodystrophy: A Clinical Trial

Vallejo, Alfonso; Garcia-Ruano, Angela A.; Pinilla, C. Fernandez; Castellano, M.; Deleyto, Esther; Pérez-Cano, Rosa

doi:10.1097/prs.0000000000004173

Cited by 11 publications

(19 citation statements)

References 22 publications

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“…Autologous fat transplantation is considered an ideal method for soft tissue surgery and repair in plastic and reconstructive surgery due to its bioavailability and biocompatibility [ 1 ]. Fat grafting for reconstruction or aesthetic surgery usually requires multiple transplantations to achieve the treatment goals due to its unpredictable absorption rates [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of glycerol as a cryoprotective agent in the cryopreservation of adipose tissue

et al. 2022

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Background Long-term preservation of adipose tissue is crucial for clinical applications. Researchers should consider both efficiency and biosafety when choosing a cryoprotective agent (CPA) for adipose tissue preservation. Glycerol has been applied as a nontoxic CPA for multiple tissues but not adipose tissue. We aimed to evaluate the efficacy of glycerol as a CPA for adipose tissue cryopreservation. Methods Fresh human adipose tissues were obtained from patients who underwent liposuction and divided into 1 mL samples. Each sample was randomly mixed with 1 mL of CPA: 60–100% glycerol, 0.25 mol/L trehalose or DMSO + FBS and cryopreserved in − 196 °C liquid nitrogen for one month. After thawing and elution, the tissues were immediately evaluated for activity and structural integrity in vitro. Then, 0.2 mL of each sample was transplanted subdermally to the nude mouse dorsum and harvested after one month for histological examination to assess the effect of the cryopreserved fat in transplantation. Results After cryopreservation, the samples treated with DMSO + FBS, trehalose, 60% and 70% glycerol had a more integrated structure than the samples in other groups. Tissues preserved with 70% glycerol had the highest G3PDH activity of 24.41 ± 0.70, comparable to 24.76 ± 0.48 in fresh tissue (p > 0.05). Adipose-derived stem cells (ASC) viability, proliferation and differentiation capability were also better preserved in 70% glycerol group. In vivo analysis showed that tissue preserved with 70% glycerol had a retention rate of 52.37 ± 7.53%, significantly higher than other groups. Histological observation demonstrated better structural integrity and viability in 70% glycerol group. Compared to the DMSO + FBS and trehalose groups, the glycerol groups showed lower tissue inflammation. Conclusion Glycerol (70%) is efficient in adipose tissue cryopreservation. Glycerol-based CPAs, which are nontoxic and show biosafety, are a promising solution for clinical tissue cryopreservation.

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Section: Introductionmentioning

confidence: 99%

The effect of glycerol as a cryoprotective agent in the cryopreservation of adipose tissue

et al. 2022

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“…A summary of studies included concerning HIV-FLA is reported in Table 2. [16][17][18][19] Injections were performed subdermally or supraperiostally with needles or cannulas. Variables assessed included determining improvement in all treated patients, evaluated according to Fontdevila's FLA grade or the global assessment improvement scale (GAIS), without any adverse events.…”

Section: Hiv-associated Facial Lipoatrophymentioning

confidence: 99%

A systematic review of Radiesse/calcium hydroxylapatite and carboxymethylcellulose: evidence and recommendations for treatment of the face

Guida,

Galadari

2023

Int J Dermatology

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Radiesse® is a filler composed of calcium hydroxylapatite microspheres suspended in a carboxymethylcellulose gel (CaHA/CMC). It has robust rheological properties that have been associated with its versatility. CaHA/CMC is employed for both on‐label indications of filling wrinkles or lines, volumizing, and contouring of areas as well as off‐label indications aiming at biostimulation and skin tightening. However, despite the expanding use of CaHA/CMC, overall evidence and recommendations for treatment are currently lacking. This paper aims to provide an up‐to‐date overview of CaHA/CMC clinical applications, together with a level of evidence of supporting literature, focusing on the face. Based on the data, CaHA/CMC may be considered a safe and effective treatment option for cheeks, jawline, HIV‐related facial lipoatrophy, and nasolabial folds. Treatment of marionette lines, chin, pre‐jowl, and corner of the mouth also tends to respond with a high degree of efficacy. Despite the recent trend, guidelines, and safety profile of diluted and hyperdiluted Radiesse®, no randomized controlled trials have been published.

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“…Human immunodeficiency virus treated with highly active antiretroviral therapy can result in facial lipoatrophy in these patients. 42 The FDA has approved use of calcium hydroxylapatite and poly-L-lactic acid for filling volume loss in the contours of the cheeks, temples, and orbits. 42 There are new emerging uses for facial fillers currently being adopted into practice.…”

Section: Injectable Fillersmentioning

confidence: 99%

“…42 The FDA has approved use of calcium hydroxylapatite and poly-L-lactic acid for filling volume loss in the contours of the cheeks, temples, and orbits. 42 There are new emerging uses for facial fillers currently being adopted into practice. Filler use in the temporal areas can correct for loss of volume, preventing a gaunt facial appearance.…”

Section: Injectable Fillersmentioning

confidence: 99%

Tissue Modification in Nonsurgical Facelift Options

2020

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Nonsurgical facelifts are a term for a heterogeneous group of procedures used by physicians to improve facial rejuvenation without the use of operative techniques. Patients demand these services due to the reduced recovery time and generally lower risk. However, nonsurgical techniques, to be effective, must induce conformational change in the cells and tissues of the face. Therefore, these techniques are significant procedures that have associated risks. Understanding the tissue modifications and mechanisms of action of these techniques is vital to their safe and effective use. The purpose of this article is to provide a background of tissue modification in nonsurgical facelift options.

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Comparing Efficacy and Costs of Four Facial Fillers in Human Immunodeficiency Virus–Associated Lipodystrophy: A Clinical Trial

Cited by 11 publications

References 22 publications

The effect of glycerol as a cryoprotective agent in the cryopreservation of adipose tissue

The effect of glycerol as a cryoprotective agent in the cryopreservation of adipose tissue

A systematic review of Radiesse/calcium hydroxylapatite and carboxymethylcellulose: evidence and recommendations for treatment of the face

Tissue Modification in Nonsurgical Facelift Options

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