Comparing Effectiveness of Gabapentin and Pregabalin in Treatment of Neuropathic Pain: A Retrospective Cohort of Palliative Care Outpatients

Dragic, Lisa; Webb, Thomas; Chandler, Michael J.; Harrington, Sarah Beth; McDade, Elizabeth; Dayer, Lindsey; Painter, Jacob T.

doi:10.1080/15360288.2020.1784354

Cited by 1 publication

(1 citation statement)

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“…[20] The binding of gabapentinoids to the receptor inhibits the secretion of excitatory neurotransmitters, such as glutamate, norepinephrine, and substance P, in the spinal and supraspinal pathways. [21] Paradoxically, due to the effect of these drugs as "neuromodulators," they are currently used more widely for managing neuropathic pain, not for epilepsy. GBP was first synthesized in 1976 as a substance similar to GABA for treating rigidity and epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Comparing the therapeutic effects of pregabalin and gabapentin after transforaminal epidural nerve block in lumbar radiculopathy

2022

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Lumbar radiculopathy can be presented as low back pain and radiating pain. Transforaminal epidural steroid injection (TFESI) has been used to treat radicular pain, and after the injection, additional medications such as gabapentinoids including pregabalin (PGB) and gabapentin (GBP) can be administered to relieve remnant pain. However, little is known about the effectiveness of gabapentinoids in relieving pain after transforaminal epidural steroid injection. This study was conducted to compare the effect of pregabalin and gabapentin in lumbar radiculopathy patients who underwent transforaminal epidural steroid injection. One hundred seven patients who received TFESI and had taken PGB or GBP after the intervention at Daegu Catholic University Medical Center from January 2013 to August 2021 were included in this study. Visual Analogue Scale (VAS) was evaluated in all patients. Among 107 patients, 57 (53.3%) patients took PGB and 50 (46.7%) patients took GBP after TFESI. The PGB and GBP groups showed reduced VAS scores according to visit ( P < .001). However, no statistically signific a nt differences in VAS scores according to the types of medication ( P = .811) and change aspects according to visit were observed between the PGB and GBP groups ( P = .947). The study findings suggest that both pregabalin and gabapentin can be equally used to reduce pain in lumbar radiculopathy patients who underwent TFESI. Further studies with larger sample size are needed to generalize the findings of this study.

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Section: Discussionmentioning

confidence: 99%