Comparative Veterinary Pharmacokinetics

Jerzsele, Ákos

doi:10.5772/33740

Cited by 10 publications

(9 citation statements)

References 50 publications

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“…This is because the muscle tissue has a greater blood supply and holds a larger volume of drug than the subcutaneous tissue (Yáñez et al., ). As the gastrointestinal tract of sheep has a large volume and passing time, food–drug interactions may prolong the absorption of drug after OR administration (Jerzsele, ). The absorption rate and extent of drug according to the administration route and food–drug interaction may explain the differences observed in the C max and T max in this study.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and bioavailability of tolfenamic acid in sheep

Çorum

et al. 2018

Vet Pharm & Therapeutics

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The pharmacokinetics, bioavailability, and tolerability of tolfenamic acid (TA) were determined after treating sheep with TA via different routes and doses. This crossover study was carried out with a washout period of 15 days. In the study, 16 clinically healthy sheep were randomly assigned to two equal groups. In the first group (n = 8), animals received TA by intravenous (IV), intramuscular (IM), subcutaneous (SC), or oral (OR) routes at 2 mg/kg. In the second group (n = 8), TA was administered intravenously to each sheep at 2, 4, 8, and 16 mg/kg. Plasma samples were analyzed with a high-performance liquid chromatography assay. Noncompartmental pharmacokinetic analyses were used to evaluate the data. The area under the concentration-time curves (AUC ), elimination half-life (t ), and the mean residence time (MRT) significantly differed among the administration routes at 2 mg/kg of TA. Following IM, SC, and OR administrations, TA demonstrated different peak concentrations (C ) and time to reach C (T ), with a bioavailability of 163%, 127%, and 107%, respectively. The dose-normalized AUC revealed a significant difference among the dose groups; however, the relationship between dose and AUC was linear. Both t and MRT increased depending on the dose. Although the total clearance (Cl ) decreased depending on dose, the volume of distribution at steady-state (V ) increased. Tolfenamic acid indicated a long half-life and high bioavailability following IM, SC, and OR administrations at 2 mg/kg. TA exhibited linear kinetics and was well tolerated by the animals, except at 16 mg/kg. Thus, TA may be used in different routes and doses (≤8 mg/kg) in sheep; however, further studies are needed to determine the clinical efficacy of TA during the inflammatory and painful conditions and the pharmacokinetics and safety of repeated administration in sheep.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and bioavailability of tolfenamic acid in sheep

Çorum

et al. 2018

Vet Pharm & Therapeutics

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“…Speciesafhankelijke verschillen in farmacokinetiek kunnen het gevolg zijn van verschillen in absorptie, distributie en/of eliminatie, bestaande uit biotransformatie en excretie (Baert, 2003;Jerzsele, 2012).…”

Section: Beginselen Van De Farmacokinetische Processenunclassified

Farmacokinetiek van geneesmiddelen bij vogels en de toepassingen en beperkingen van dosisextrapolatie

Houben¹,

Antonissen²,

Croubels³

et al. 2016

Vlaams Diergeneeskundig Tijdschrift

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De farmacokinetische processen van geneesmiddelen, i.e. absorptie, distributie, metabolisatie en excretie, kunnen sterk verschillen tussen vogels en zoogdieren. Zo worden aminoglycosiden bij vogels trager geklaard en hebben een lager distributievolume dan bij zoogdieren. Deze farmacokinetische verschillen zijn hoofdzakelijk het gevolg van anatomische, biochemische en fysiologische verschillen tussen vogels en zoogdieren. Deze diersoortverschillen en verschillen in geobserveerde en voorspelde farmacokinetische parameters van geneesmiddelen bij vogels geëxtrapoleerd vanuit zoogdieren, zoals de klaring voor enrofloxacine, salicylzuur, meloxicam en flunixine, wijzen erop dat farmacokinetische gegevens van een geneesmiddel bij zoogdieren nauwelijks geëxtrapoleerd kunnen worden naar vogels. Ook tussen vogelsoorten onderling kunnen er verschillen aanwezig zijn. Indien mogelijk dient de dosisselectie van een geneesmiddel voor vogels bijgevolg te gebeuren op basis van de farmacokinetische gegevens van de desbetreffende vogelsoort. Indien dergelijke gegevens niet beschikbaar zijn, kan er gebruik gemaakt worden van allometrische schaling, waarbij de dosisselectie gebeurt op basis van de farmacokinetische gegevens van een andere vogelsoort gecorreleerd aan het lichaamsgewicht van deze vogelsoorten. Schaling op basis van zoogdiergegevens wordt slechts aangeraden indien de farmacokinetische gegevens van andere vogelsoorten niet beschikbaar zijn en het betreffende geneesmiddel een lage toxiciteit heeft.

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“…The pharmacokinetic parameters of IVM vary extensively and can influence the concentration of the drug in the plasma. Thus, factors such as species, route of administration, drug formulation, body weight, body condition, and amount and type of nutrition are some of the many factors that can all influence the plasma concentration of the drug (Górniak, 2014; Jerzsele, 2012). In addition, pharmacokinetic parameters are fundamental to the rational use of a drug, and when considering food safety, these parameters reveal the residue concentrations in edible tissue and the withdrawal time from a food animal (Palermo‐Neto & Righi, 2014).…”

Section: Introductionmentioning

confidence: 99%

The effect of breed, sex, and drug concentration on the pharmacokinetic profile of ivermectin in cattle

Gotardo

Fonseca

Barreto

et al. 2020

Vet Pharm & Therapeutics

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Ivermectin (IVM) is one of the most widely used antiparasitic drugs worldwide and has become the drug of choice for anthelmintic and tick treatment in beef cattle production. It is known that pharmacokinetic parameters are fundamental to the rational use of a drug and food safety and these parameters are influenced by different factors. The aim of this study was to evaluate the pharmacokinetic profile of IVM in Bos indicus, Bos taurus, and crossbreed cattle (B. indicus × B. taurus) kept under same field conditions and the possible impacts of sex and IVM formulation (1% and 3.15%). It was observed that IVM concentration was significantly affected by breed. The plasma concentrations of IVM, AUC, Cmax, and t1/2β were significantly higher in B. indicus compared to B. taurus. Crossbreed animals showed an intermediate profile between European and Indian cattle. No alteration in pharmacokinetics parameters was detected when comparing different gender. Concerning the pharmacokinetic data of IVM formulation, it was verified that Tmax, AUC, and t1/2β were higher in 3.15% IVM animals than those from 1% IVM formulation. The results clearly indicated that the IVM plasma concentrations in B. indicus were higher than that in B. taurus.

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Comparative Veterinary Pharmacokinetics

Cited by 10 publications

References 50 publications

Pharmacokinetics and bioavailability of tolfenamic acid in sheep

Pharmacokinetics and bioavailability of tolfenamic acid in sheep

Farmacokinetiek van geneesmiddelen bij vogels en de toepassingen en beperkingen van dosisextrapolatie

The effect of breed, sex, and drug concentration on the pharmacokinetic profile of ivermectin in cattle

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