Comparative trial of clinical relaxation and an antiemetic drug regimen in reducing chemotherapy-related nausea and vomiting

Scott, D. W.; Donahue, Dorothy C.; Mastrovito, Rene C.; Hakes, Thomas B.

doi:10.1097/00002820-198608000-00005

Cited by 16 publications

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“…Results from a study by Arakawa [ 45 ] in 60 Japanese patients who were hospitalized in a cancer centre receiving chemotherapy verified the effectiveness of progressive muscle relaxation in reducing total scores used to measure nausea, vomiting, and retching. Scott et al [ 46 ] compared a clinical relaxation program that included guided imagery with a standard antiemetic drug protocol for chemotherapy. The patients in the relaxation program experienced less and shorter episodes of nausea and vomiting.…”

Section: Discussionmentioning

confidence: 99%

Guided Imagery And Progressive Muscle Relaxation as a Cluster of Symptoms Management Intervention in Patients Receiving Chemotherapy: A Randomized Control Trial

et al. 2016

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ObjectivePatients receiving chemotherapy often experience many different symptoms that can be difficult to alleviate and ultimately negatively influence their quality of life. Such symptoms include pain, fatigue, nausea, vomiting and retching, anxiety and depression. There is a gap in the relevant literature on the effectiveness of cognitive-behavioural and relaxation techniques in symptom clusters. The study reflects this gap in the literature and aimed to test the effectiveness of Guided Imagery (GI) and Progressive Muscle Relaxation (PMR) on a cluster of symptoms experienced by patients undergoing chemotherapy.MethodsThis was a randomized control trial with 208 patients equally assigned either in the intervention or the control group. Measurements in both groups were collected at baseline and at completion of intervention (4 weeks). Patients were assessed for pain, fatigue, nausea, vomiting and retching, anxiety and depression. The overall management of the cluster was also assessed based on the patients’ self-reported health related quality of life-HRQoL. Chi-square tests (X2), independent T-tests and Linear Mixed Models were calculated.ResultsPatients in the intervention group experienced lower levels of Fatigue (p<0.0.0225), and Pain (p = 0.0003) compared to those in the control group and experienced better HRQoL (p<0.0001) [PRE-POST: Intervention: Pain 4.2(2.5) - 2.5(1.6), Fatigue 27.6(4.1) - 19.3(4.1), HRQoL 54.9(22.7) - 64.5(23), Control: Pain 3.5(1.7) - 4.8(1.5), Fatigue 28.7(4.1) - 32.5(3.8), HRQoL 51.9(22.3)– 41.2(24.1)]. Nausea, vomiting and retching occurred significantly less often in the intervention group [pre-post: 25.4(5.9)– 20.6(5.6) compared to the control group (17.8(6.5)– 22.7(5.3) (F = 58.50 p<0.0001). More patients in the control group (pre:n = 33-post:n = 47) were found to be moderately depressed compared to those in the intervention group (pre:n = 35-post:n = 15) (X2 = 5.93; p = 0.02).ConclusionThis study provided evidence that the combination of GI and PMR can be effective in the management of a cluster of symptoms in cancer patients receiving chemotherapy. These techniques can complement existing management measures to achieve a comprehensive management of this symptom cluster and increase patients HRQoL.Trial RegistrationClinicalTrials.gov NCT01275872

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Section: Discussionmentioning

confidence: 99%

Guided Imagery And Progressive Muscle Relaxation as a Cluster of Symptoms Management Intervention in Patients Receiving Chemotherapy: A Randomized Control Trial

et al. 2016

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“…Frank 92 reported that patients who underwent guided imagery had a significantly lower perceived degree of vomiting and a decrease in the duration of vomiting. Scott et al compared a clinical relaxation program that included guided imagery with a standard antiemetic drug protocol for chemotherapy 99 . The drug protocol was more effective in reducing the number of episodes of nausea and vomiting; however, the total duration of nausea and vomiting was four hours shorter with the relaxation program.…”

Section: Nonpharmacologic Management Of Nvrmentioning

confidence: 99%

Nausea, Vomiting, and Retching: Complex Problems in Palliative Care

Rhodes

McDaniel

2001

CA: A Cancer Journal for Clinicians

115

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Patients with advanced cancer commonly experience nausea, vomiting, and/or retching (NVR) as a result of the malignant process and its treatment. Recently, increasing attention is being focused on end-of-life care, which includes relief or reduction of symptoms such as NVR.Pre-chemotherapy preparation and patient education in the palliative care setting are essential to preventing acute and delayed distress from NVR, as well as anticipatory symptoms. Careful assessment of chemotherapy-related symptoms should distinguish between the three phenomena rather than taking a global approach. Strategies for preventing anticipatory nausea, for instance, may differ significantly from those designed to reduce frequency of vomiting.Management of anticancer treatment-related NVR should incorporate both pharmacologic and nonpharmacologic approaches, whenever appropriate, with the overall goal of improving and/or maintaining the patient's quality of life. (CA Cancer J Clin 2001;51:232-248.) INTRODUCTION Nausea, vomiting, and retching (NVR) are among the most common and distressing symptoms that patients with cancer endure, both as a result of antineoplastic treatment and from the disease itself. [1][2][3][4][5][6] Nausea and vomiting are the most frequently reported adverse effects of antineoplastic chemotherapy and significantly affect patients' daily functioning, quality of life, and compliance with therapy. [6][7][8] Effective management of these individual symptoms during initial and continued therapy profoundly influences symptom response throughout the cancer trajectory. Even mild NVR may have later sequelae, e.g., anticipatory symptoms in patients receiving chemotherapy.Recently, increasing attention has been given to the management of NVR during the end of life, 9 a time when many receive palliative care. Palliate, according to Merriam Webster 's New Collegiate Dictionary (1998), means "to reduce the violence of (a disease)"; in other words, to alleviate or to lessen the severity without curing. 10 In 1990, the World Health Organization 11 expanded this definition: "Palliative care is the active total care of patients whose disease is not responsive to curative treatment."Palliative care, traditionally associated with end-of-life care, is a program of active, Newer aggressive therapies demand the integration of palliative services throughout the illness trajectory. 13 Although technological therapeutic advances have extended life and can provide relief for symptoms of disease, numerous complications, side effects, and lifestyle changes are associated with these advances. These changes and symptoms can impair quality of life for cancer patients and families. 8,9,[14][15][16] SIGNS VERSUS SYMPTOMSMany studies have addressed quality of life in oncology patients, focusing specifically on symptom control. 2,4,[17][18][19][20][21] While chemotherapy and radiation therapy may no longer be indicated for curative effect in those with advanced disease, they may provide dramatic palliation of pain, constipation, obst...

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Nonpharmacologic factors in the development of posttreatment nausea with adjuvant chemotherapy for breast cancer

Jacobsen

Die-Trill

Holland

et al. 1988

Cancer

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A prospective, longitudinal design was used to determine the role of nonpharmacologic factors in the development of posttreatment nausea (PTN). Forty-five women with no previous chemotherapy experience who were receiving a single regimen of adjuvant chemotherapy for breast cancer were interviewed before and after their first six infusions. Seventy-one percent of patients developed PTN. The PTN was related to the following: patients' physical status at the onset of treatment; heightened anxiety during infusions; susceptibility to nausea and vomiting after eating certain foods; and expectations of developing chemotherapy-related nausea. Anxiety during infusions, susceptibility to nausea and vomiting, and expectations of side effects also accounted for differences in the frequency, intensity, and severity of PTN. These findings offer strong support for the view that nonpharmacologic factors contribute to individual differences in gastrointestinal responses to chemotherapy.

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Comparative trial of clinical relaxation and an antiemetic drug regimen in reducing chemotherapy-related nausea and vomiting

Cited by 16 publications

References 0 publications

Guided Imagery And Progressive Muscle Relaxation as a Cluster of Symptoms Management Intervention in Patients Receiving Chemotherapy: A Randomized Control Trial

Guided Imagery And Progressive Muscle Relaxation as a Cluster of Symptoms Management Intervention in Patients Receiving Chemotherapy: A Randomized Control Trial

Nausea, Vomiting, and Retching: Complex Problems in Palliative Care

Nonpharmacologic factors in the development of posttreatment nausea with adjuvant chemotherapy for breast cancer

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