Nonpharmacologic factors in the development of posttreatment nausea with adjuvant chemotherapy for breast cancer

Jacobsen, Paul B.; Die-Trill, Maria; Holland, Jimmie C.; Andrykowski, Michael A.; Redd, William H.; Hakes, Thomas B.; Kaufman, Richard J.; Currie, Violante E.

doi:10.1002/1097-0142(19880115)61:2<379::aid-cncr2820610230>3.0.co;2-e

Cited by 83 publications

(85 citation statements)

References 17 publications

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“…While the relationship between state anxiety and gastrointestinal distress has been discussed earlier (23)(24)(25), little research has examined the relationship between state anxiety and PNV. An exception is the study by Jacobsen et al (51). Using a multivariate model, they found that state anxiety was associated with a greater prevalence, frequency, and severity of postchemotherapy nausea.…”

Section: Causal Relationships Between Anv and Anxietymentioning

confidence: 98%

The role of anxiety in the development of anticipatory nausea in cancer chemotherapy: a review and synthesis.

Andrykowski

1990

Psychosomatic Medicine

101

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The role of state anxiety in the development of anticipatory nausea and vomiting (ANV) in cancer chemotherapy has been the focus of considerable empirical investigation and theoretical speculation. However, while some relationship between state anxiety and ANV is presumed to exist, determination of its precise nature has proven elusive. Specific hypotheses linking state anxiety to ANV are described and evaluated in light of the empirical evidence. These hypotheses include (a) ANV is a symptomatic concomitant of state anxiety; (b) state anxiety directly facilitates the classical conditioning of ANV; (c) state anxiety exacerbates the magnitude of post-treatment nausea and vomiting experienced, thus increasing the risk of ANV; (d) ANV causes infusion-related state anxiety; and (e) the observed relationship between ANV and state anxiety is a result of methodological artifact. It is concluded that state anxiety can play a causal role in the development of ANV in some patients. In particular, the hypothesis that state anxiety exacerbates post-treatment nausea and vomiting and thus increases the risk for ANV appears best supported by the data. Finally, the clinical implications of the relationship between ANV and state anxiety for the treatment and prevention of ANV are discussed.

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Section: Causal Relationships Between Anv and Anxietymentioning

confidence: 98%

The role of anxiety in the development of anticipatory nausea in cancer chemotherapy: a review and synthesis.

Andrykowski

1990

Psychosomatic Medicine

101

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“…7,[24][25][26] Anxiety is known to affect the development of NV at least in part through negative expectancies, 24,[27][28][29] and, reciprocally, negative expectancies are instrumental in the development of anxiety. 16,30 Expectancies affect the generation of conditioning effects, [31][32][33] and, conversely, conditioning influences response expectancies.…”

Section: Introductionmentioning

confidence: 99%

Chemotherapy-induced Nausea and Vomiting

Mustian

Darling

Janelsins

et al. 2008

Oncology &Amp; Hematology Review (US)

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Despite treatment advances, nausea and vomiting, especially anticipatory nausea and vomiting, delayed nausea and vomiting and nausea alone, are still the most common, expected and feared side effects among patients receiving chemotherapy. Of the 70 to 80% of cancer patients who experience chemotherapy-induced nausea and vomiting many will delay or refuse future chemotherapy treatments and contemplate stopping all treatments because of fear of further nausea and vomiting. The purpose of this chapter is to provide an overview of the pathopsychophysiology of CINV, the recommended guidelines for standard treatment, and highlight newer targeted treatment approaches.

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“…However, it should be noted that the relationship between anxiety and nausea is based primarily on the higher probability of occurrence of nausea in subjects with higher anxiety levels [2,21,23,37,42], and correlations between degree of anxiety and magnitude of nausea are weak [27,44]; the present A C C E P T E D M A N U S C R I P T study only models the latter situation. Taking the results at face value, motion clearly produced hypothermia in all three lines, and this is consistent with previous studies of hypothermia induced by a number of emetic stimuli in both rats (lacking an emetic reflex [19]) and Suncus murinus (with an emetic reflex) [9,17,35].…”

Section: Do Our Findings Challenge the Validity Of The "Hypothermia Nmentioning

confidence: 75%

“…Nausea and vomiting are among the key symptoms of generalized anxiety disorder and of panic attacks [31]. Anxious subjects are more susceptible to anticipatory and therapeutic-induced nausea and vomiting resulting from chemotherapy [2,21], and the level of nausea and vomiting following surgery is positively correlated with preoperative anxiety magnitude [28,44]. Anxiety is considered to be a sensitising factor for air and motion sickness [23,37,42], and subjects with a better ability to handle stress have a lower risk of being motion sick [20].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Autonomic changes induced by provocative motion in rats bred for high (HAB) and low (LAB) anxiety-related behavior: Paradoxical responses in LAB animals

Carnevali

Andrews

Neumann

et al. 2016

Physiology & Behavior

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In humans, associations between anxiety and nausea (including motion-induced) are reported but the underlying mechanisms are not known. Hypothermia is proposed to be an index of nausea in rats. Utilising hypothermia and heart rate as outcome measures we investigated the response to provocative motion in rats selectively bred for high (HAB) and low (LAB) anxiety-related behaviors and in non-selected (NAB) rats to further elucidate the potential relationship between hypothermia and nausea-like state. Core temperature and electrocardiogram were monitored in each group (N=10 per group) using telemetry, with or without circular motion (40min; 0.75Hz) and vehicle or diazepam (2mg/kg, i.p.) pre-treatment.Heart rate and time-and frequency-domain parameters of heart rate variability were derived from the electrocardiogram. There was no baseline difference in core temperature between the three groups (mean 38.0±0.1 o C), but HAB animals had a significantly lower resting heart rate (330±7 bpm) compared to LAB (402±5 bpm) and NAB (401±9 bpm). Animals in all groups exhibited hypothermia during motion (HAB: 36.3±0.1 o C; NAB: 36.4±0.1 o C; LAB: 34.9±0.2 o C) with the magnitude (area under the curve, AUC) of the response during 40-min motion being greater in LAB compared to NAB and HAB rats, and this was also the case for the motion-induced bradycardia. Diazepam had minimal effects on baseline temperature and heart rate in all groups, but significantly reduced the hypothermia response (AUC) to motion in all groups by ~30%. Breeding for extremes in anxiety-related behavior unexpectedly selects animals with low trait anxiety that have enhanced bradycardia and hypothermic responses to motion; consequently, this animal model appears to be not suitable for exploring relationships between anxiety and autonomic correlates of nausea. Thermal and cardiovascular responses to motion were little different between HAB and NAB rats indicating that either hypothermia is not an index of a nausea-like state in rats, or that the positive correlation between anxiety and nausea demonstrated in humans does not exist in rats. The mechanism underlying the enhanced physiological responses in LAB requires more detailed study and may provide a novel model to investigate factors modulating motion sensitivity.

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Nonpharmacologic factors in the development of posttreatment nausea with adjuvant chemotherapy for breast cancer

Cited by 83 publications

References 17 publications

The role of anxiety in the development of anticipatory nausea in cancer chemotherapy: a review and synthesis.

The role of anxiety in the development of anticipatory nausea in cancer chemotherapy: a review and synthesis.

Chemotherapy-induced Nausea and Vomiting

Autonomic changes induced by provocative motion in rats bred for high (HAB) and low (LAB) anxiety-related behavior: Paradoxical responses in LAB animals

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