Comparative toxicity and carcinogenicity of soluble and insoluble cobalt compounds

Behl, Mamta; Stout, Matthew D.; Herbert, Ronald A.; Dill, Jeffrey A.; Baker, Gregory L.; Hayden, Barry K.; Roycroft, Joseph H.; Bucher, John R.; Hooth, Michelle J.

doi:10.1016/j.tox.2015.04.008

Cited by 50 publications

(14 citation statements)

References 43 publications

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“…The findings from the nested case-control study of lung cancer were consistent with the lung cancer SMR from the cohort analysis, although based on very small numbers (17,18) .…”

Section: Findings From This Studysupporting

confidence: 52%

Mortality Among Hardmetal Production Workers

McElvenny

MacCalman

Sleeuwenhoek

et al. 2017

Journal of Occupational &Amp; Environmental Medicine

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“…The findings from the nested case-control study of lung cancer were consistent with the lung cancer SMR from the cohort analysis, although based on very small numbers (17,18) .…”

Section: Findings From This Studysupporting

confidence: 52%

Mortality Among Hardmetal Production Workers

McElvenny

MacCalman

Sleeuwenhoek

et al. 2017

Journal of Occupational &Amp; Environmental Medicine

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“…Interestingly, cobalt (Co) NPs induced the Rtkn reporter suggesting DNA damage and NFκB signaling. Cobalt dust has been reported to cause lung cancer in 2-y inhalation studies in rats and mice (145). …”

Section: Modifications Of the Automated Fadu Assaymentioning

confidence: 99%

Emerging metrology for high-throughput nanomaterial genotoxicology

Nelson

Wright

Ibuki

et al. 2016

MUTAGE

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The rapid development of the engineered nanomaterial (ENM) manufacturing industry has accelerated the incorporation of ENMs into a wide variety of consumer products across the globe. Unintentionally or not, some of these ENMs may be introduced into the environment or come into contact with humans or other organisms resulting in unexpected biological effects. It is thus prudent to have rapid and robust analytical metrology in place that can be used to critically assess and/or predict the cytotoxicity, as well as the potential genotoxicity of these ENMs. Many of the traditional genotoxicity test methods [e.g. unscheduled DNA synthesis assay, bacterial reverse mutation (Ames) test, etc.,] for determining the DNA damaging potential of chemical and biological compounds are not suitable for the evaluation of ENMs, due to a variety of methodological issues ranging from potential assay interferences to problems centered on low sample throughput. Recently, a number of sensitive, high-throughput genotoxicity assays/platforms (CometChip assay, flow cytometry/micronucleus assay, flow cytometry/γ-H2AX assay, automated ‘Fluorimetric Detection of Alkaline DNA Unwinding’ (FADU) assay, ToxTracker reporter assay) have been developed, based on substantial modifications and enhancements of traditional genotoxicity assays. These new assays have been used for the rapid measurement of DNA damage (strand breaks), chromosomal damage (micronuclei) and for detecting upregulated DNA damage signalling pathways resulting from ENM exposures. In this critical review, we describe and discuss the fundamental measurement principles and measurement endpoints of these new assays, as well as the modes of operation, analytical metrics and potential interferences, as applicable to ENM exposures. An unbiased discussion of the major technical advantages and limitations of each assay for evaluating and predicting the genotoxic potential of ENMs is also provided.

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“…As the metal constituent of vitamin B 12 , Co plays a biologically essential role [12]. Meanwhile, the 13th Report on Carcinogens (ROC) lists "cobalt sulfate" and "cobalt-tungsten carbide: powders and hard metals" as being reasonably anticipated to be human carcinogens [13], the study had found that cobalt metal may induce lung cancer [14]. Moreover, as a non-essential trace element, Tl had been recognized internationally as one of the 13 priority pollutants [15].…”

Section: Introductionmentioning

confidence: 99%

Anthropogenic Impact and Ecological Risk Assessment of Thallium and Cobalt in Poyang Lake Using the Geochemical Baseline

Zhang

et al. 2018

Water

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As the largest freshwater lake in China, water environmental pollution in Poyang Lake is increasingly attracting attention. However, to date, the occurrence of seldom-monitored trace elements (SMTEs) (such as thallium (Tl) and cobalt (Co)) and their potential ecological influences in the Poyang Lake area remain unclear. Here, geochemical baseline concentrations (GBCs) were employed to investigate anthropogenic inputs of these two metals (Tl and Co) and were used to assess the potential ecological risk in surface sediments of Poyang Lake. The results showed that the mean concentrations of Tl and Co were 1.11 mg/kg and 15.42 mg/kg, respectively, slightly higher than background values (BVs) in local soil. Spatially, the Co concentrations in surface sediments of Poyang Lake varied; Co concentrations in the west of the study area were significantly lower than in the middle of the lake. In contrast, no significant spatial variation of Tl was found in studied areas of Poyang Lake. Average GBCs were similar to the mean measured concentrations of Tl and Co in the lake, and both were higher than the BVs in local soil. In anthropogenic source analysis based on the GBCs, 47.22% samples and 41.67% samples were influenced by human activity for Tl and Co, respectively; the mean anthropogenic contribution rate was 5.90% for Tl (0.43 to 16.22%), and 13.01% for Co (0.82 to 31.59%). These results indicated that Tl and Co mainly originate from natural processes. However, the anthropogenic contribution should not be ignored. Moreover, the geo-accumulation index (Igeo) and potential ecological parameter (Er) generally indicated no contamination and a low potential risk for Tl and Co in Poyang Lake sediments, which used the GBCs as BVs. The results of this study suggest that GBCs are more scientifically robust and practical as a reference than BVs. They can also be used when BVs are lacking.

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Comparative toxicity and carcinogenicity of soluble and insoluble cobalt compounds

Cited by 50 publications

References 43 publications

Mortality Among Hardmetal Production Workers

Mortality Among Hardmetal Production Workers

Emerging metrology for high-throughput nanomaterial genotoxicology

Anthropogenic Impact and Ecological Risk Assessment of Thallium and Cobalt in Poyang Lake Using the Geochemical Baseline

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